Human Papovavirus (JC): Induction of Brain Tumors in Hamsters
Eighty-three percent of hamsters inoculated at birth with JC virus, a human papovavirus isolated from brain tissue of a case of progressive multifocal leukoencephalopathy, developed malignant gliomas within 6 months. Three brain tumors have been serially transplanted as subcutaneous tumors. JC virus...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1973-08, Vol.181 (4100), p.674-676 |
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| container_issue | 4100 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Walker, Duard L. Padgett, Billie L. ZuRhein, Gabriele M. Albert, Albertina E. Marsh, Richard F. |
| description | Eighty-three percent of hamsters inoculated at birth with JC virus, a human papovavirus isolated from brain tissue of a case of progressive multifocal leukoencephalopathy, developed malignant gliomas within 6 months. Three brain tumors have been serially transplanted as subcutaneous tumors. JC virus was isolated from five of seven tumors tested. Cells from four tumors were cultivated in vitro. These cells contained an intranuclear antigen with the characteristics of a T antigen, and this antigen was antigenically related to SV40 T antigen. Although virus was not recovered from extracts of serially cultured tumor cells, JC virus was rescued when one tumor cell line was fused with permissive cells. |
| doi_str_mv | 10.1126/science.181.4100.674 |
| format | Article |
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Three brain tumors have been serially transplanted as subcutaneous tumors. JC virus was isolated from five of seven tumors tested. Cells from four tumors were cultivated in vitro. These cells contained an intranuclear antigen with the characteristics of a T antigen, and this antigen was antigenically related to SV40 T antigen. Although virus was not recovered from extracts of serially cultured tumor cells, JC virus was rescued when one tumor cell line was fused with permissive cells.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.181.4100.674</identifier><identifier>PMID: 4353360</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animals ; Antibodies, Viral - analysis ; Antigens ; Antigens, Viral - analysis ; Brain Neoplasms - etiology ; Brain Neoplasms - immunology ; Brain Neoplasms - pathology ; Cell culture techniques ; Cell Line ; Cell lines ; Cricetinae ; Cultured cells ; Fluorescent Antibody Technique ; Glioblastoma - etiology ; Glioblastoma - immunology ; Glioblastoma - pathology ; Glioma - etiology ; Glioma - immunology ; Humans ; JC virus ; Leukoencephalopathy, Progressive Multifocal - microbiology ; Neoplasms, Experimental - etiology ; Papillomaviridae - immunology ; Papillomaviridae - isolation & purification ; Polyomaviridae ; Secretion ; Tumor cell line ; Tumors ; Vero cells ; Virus Cultivation ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 1973-08, Vol.181 (4100), p.674-676</ispartof><rights>Copyright 1973 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-b4fbce579e2bf425d33fed6b46ca13be40c271eb3f33c64cb7a59fa55f8a9253</citedby><cites>FETCH-LOGICAL-c419t-b4fbce579e2bf425d33fed6b46ca13be40c271eb3f33c64cb7a59fa55f8a9253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1736961$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1736961$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4353360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walker, Duard L.</creatorcontrib><creatorcontrib>Padgett, Billie L.</creatorcontrib><creatorcontrib>ZuRhein, Gabriele M.</creatorcontrib><creatorcontrib>Albert, Albertina E.</creatorcontrib><creatorcontrib>Marsh, Richard F.</creatorcontrib><title>Human Papovavirus (JC): Induction of Brain Tumors in Hamsters</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Eighty-three percent of hamsters inoculated at birth with JC virus, a human papovavirus isolated from brain tissue of a case of progressive multifocal leukoencephalopathy, developed malignant gliomas within 6 months. Three brain tumors have been serially transplanted as subcutaneous tumors. JC virus was isolated from five of seven tumors tested. Cells from four tumors were cultivated in vitro. These cells contained an intranuclear antigen with the characteristics of a T antigen, and this antigen was antigenically related to SV40 T antigen. Although virus was not recovered from extracts of serially cultured tumor cells, JC virus was rescued when one tumor cell line was fused with permissive cells.</description><subject>Animals</subject><subject>Antibodies, Viral - analysis</subject><subject>Antigens</subject><subject>Antigens, Viral - analysis</subject><subject>Brain Neoplasms - etiology</subject><subject>Brain Neoplasms - immunology</subject><subject>Brain Neoplasms - pathology</subject><subject>Cell culture techniques</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Cricetinae</subject><subject>Cultured cells</subject><subject>Fluorescent Antibody Technique</subject><subject>Glioblastoma - etiology</subject><subject>Glioblastoma - immunology</subject><subject>Glioblastoma - pathology</subject><subject>Glioma - etiology</subject><subject>Glioma - immunology</subject><subject>Humans</subject><subject>JC virus</subject><subject>Leukoencephalopathy, Progressive Multifocal - microbiology</subject><subject>Neoplasms, Experimental - etiology</subject><subject>Papillomaviridae - immunology</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Polyomaviridae</subject><subject>Secretion</subject><subject>Tumor cell line</subject><subject>Tumors</subject><subject>Vero cells</subject><subject>Virus Cultivation</subject><subject>Viruses</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFLwzAYhoMoc07_wYSeRA-tSb8kbQQPOtRNBnrYPSRpApW1mUk78N_bsaKn74P3fZ_Dg9Cc4IyQnN9HU9vW2IyUJKME44wX9ARNCRYsFTmGUzTFGHha4oKdo4sYvzAeMgETNKHAADieosdl36g2-VQ7v1f7OvQxuX1f3D0kq7bqTVf7NvEueQ6qbpNN3_gQk-FbqiZ2NsRLdObUNtqr8c7Q5vVls1im64-31eJpnRpKRJdq6rSxrBA2147mrAJwtuKacqMIaEuxyQtiNTgAw6nRhWLCKcZcqUTOYIZujthd8N-9jZ1s6mjsdqta6_soSyJKIQoYivRYNMHHGKyTu1A3KvxIguVBmhylyUGaPEiTg7Rhdj3ye93Y6m80Whry-TH_ip0P_8wCuOAEfgG6b3LV</recordid><startdate>19730817</startdate><enddate>19730817</enddate><creator>Walker, Duard L.</creator><creator>Padgett, Billie L.</creator><creator>ZuRhein, Gabriele M.</creator><creator>Albert, Albertina E.</creator><creator>Marsh, Richard F.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19730817</creationdate><title>Human Papovavirus (JC): Induction of Brain Tumors in Hamsters</title><author>Walker, Duard L. ; Padgett, Billie L. ; ZuRhein, Gabriele M. ; Albert, Albertina E. ; Marsh, Richard F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-b4fbce579e2bf425d33fed6b46ca13be40c271eb3f33c64cb7a59fa55f8a9253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Antibodies, Viral - analysis</topic><topic>Antigens</topic><topic>Antigens, Viral - analysis</topic><topic>Brain Neoplasms - etiology</topic><topic>Brain Neoplasms - immunology</topic><topic>Brain Neoplasms - pathology</topic><topic>Cell culture techniques</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Cricetinae</topic><topic>Cultured cells</topic><topic>Fluorescent Antibody Technique</topic><topic>Glioblastoma - etiology</topic><topic>Glioblastoma - immunology</topic><topic>Glioblastoma - pathology</topic><topic>Glioma - etiology</topic><topic>Glioma - immunology</topic><topic>Humans</topic><topic>JC virus</topic><topic>Leukoencephalopathy, Progressive Multifocal - microbiology</topic><topic>Neoplasms, Experimental - etiology</topic><topic>Papillomaviridae - immunology</topic><topic>Papillomaviridae - isolation & purification</topic><topic>Polyomaviridae</topic><topic>Secretion</topic><topic>Tumor cell line</topic><topic>Tumors</topic><topic>Vero cells</topic><topic>Virus Cultivation</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walker, Duard L.</creatorcontrib><creatorcontrib>Padgett, Billie L.</creatorcontrib><creatorcontrib>ZuRhein, Gabriele M.</creatorcontrib><creatorcontrib>Albert, Albertina E.</creatorcontrib><creatorcontrib>Marsh, Richard F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walker, Duard L.</au><au>Padgett, Billie L.</au><au>ZuRhein, Gabriele M.</au><au>Albert, Albertina E.</au><au>Marsh, Richard F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Papovavirus (JC): Induction of Brain Tumors in Hamsters</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1973-08-17</date><risdate>1973</risdate><volume>181</volume><issue>4100</issue><spage>674</spage><epage>676</epage><pages>674-676</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Eighty-three percent of hamsters inoculated at birth with JC virus, a human papovavirus isolated from brain tissue of a case of progressive multifocal leukoencephalopathy, developed malignant gliomas within 6 months. Three brain tumors have been serially transplanted as subcutaneous tumors. JC virus was isolated from five of seven tumors tested. Cells from four tumors were cultivated in vitro. These cells contained an intranuclear antigen with the characteristics of a T antigen, and this antigen was antigenically related to SV40 T antigen. Although virus was not recovered from extracts of serially cultured tumor cells, JC virus was rescued when one tumor cell line was fused with permissive cells.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>4353360</pmid><doi>10.1126/science.181.4100.674</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1973-08, Vol.181 (4100), p.674-676 |
| issn | 0036-8075 1095-9203 |
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| source | Jstor Complete Legacy; MEDLINE; Science Magazine |
| subjects | Animals Antibodies, Viral - analysis Antigens Antigens, Viral - analysis Brain Neoplasms - etiology Brain Neoplasms - immunology Brain Neoplasms - pathology Cell culture techniques Cell Line Cell lines Cricetinae Cultured cells Fluorescent Antibody Technique Glioblastoma - etiology Glioblastoma - immunology Glioblastoma - pathology Glioma - etiology Glioma - immunology Humans JC virus Leukoencephalopathy, Progressive Multifocal - microbiology Neoplasms, Experimental - etiology Papillomaviridae - immunology Papillomaviridae - isolation & purification Polyomaviridae Secretion Tumor cell line Tumors Vero cells Virus Cultivation Viruses |
| title | Human Papovavirus (JC): Induction of Brain Tumors in Hamsters |
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