TRANSMISSIBLE MINK ENCEPHALOPATHY IN CARNIVORES: CLINICAL, LIGHT AND ELECTRON MICROSCOPIC STUDIES IN RACCONS, SKUNKS AND FERRETS
Four raccoons and one of two skunks inoculated with brain suspensions containing the transmissible mink encephalopathy (TME) agent developed a neurologic disease characterized by alterations of behavior, by incoordination and by slowing of motor activity. Histologic examination of the brains reveale...
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| Veröffentlicht in: | Journal of wildlife diseases 1973-07, Vol.9 (3), p.229-240 |
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| container_title | Journal of wildlife diseases |
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| creator | ECKROADE, ROBERT J. ZuRHEIN, GABRIELE M. HANSON, ROBERT P. |
| description | Four raccoons and one of two skunks inoculated with brain suspensions containing the transmissible mink encephalopathy (TME) agent developed a neurologic disease characterized by alterations of behavior, by incoordination and by slowing of motor activity. Histologic examination of the brains revealed a spongiform polioencephalopathy as is characteristic of the disease in mink. Fourteen ferrets inoculated with TME brain suspensions remained asymptomatic until sacrifice 2 years post-inoculation. A spongiform degeneration of gray matter was present in all ferret brains. However, the lesions and their topographical distribution were distinctly different from those seen in the brains of all other species susceptible to TME infection. |
| doi_str_mv | 10.7589/0090-3558-9.3.229 |
| format | Article |
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Histologic examination of the brains revealed a spongiform polioencephalopathy as is characteristic of the disease in mink. Fourteen ferrets inoculated with TME brain suspensions remained asymptomatic until sacrifice 2 years post-inoculation. A spongiform degeneration of gray matter was present in all ferret brains. However, the lesions and their topographical distribution were distinctly different from those seen in the brains of all other species susceptible to TME infection.</description><identifier>ISSN: 0090-3558</identifier><identifier>EISSN: 1943-3700</identifier><identifier>DOI: 10.7589/0090-3558-9.3.229</identifier><identifier>PMID: 4197711</identifier><language>eng</language><publisher>United States: Wildlife Disease Association</publisher><subject>Animals ; Behavior, Animal ; Brain - pathology ; Brain Diseases - complications ; Brain Diseases - microbiology ; Brain Diseases - pathology ; Brain Diseases - veterinary ; Carnivora ; Female ; Male ; Maternal-Fetal Exchange ; Microscopy, Electron ; Mink ; Movement Disorders - etiology ; Movement Disorders - veterinary ; Pregnancy ; Raccoons ; Virus Diseases - microbiology ; Virus Diseases - pathology ; Virus Diseases - veterinary ; Viruses, Unclassified</subject><ispartof>Journal of wildlife diseases, 1973-07, Vol.9 (3), p.229-240</ispartof><rights>1973 Wildlife Disease Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b280t-272aa77f32a6096318b85da5250e305c2718a8ea66dc61bceab977814b3e105e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bioone.org/doi/pdf/10.7589/0090-3558-9.3.229$$EPDF$$P50$$Gbioone$$H</linktopdf><link.rule.ids>109,314,776,780,27901,27902,52694</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4197711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ECKROADE, ROBERT J.</creatorcontrib><creatorcontrib>ZuRHEIN, GABRIELE M.</creatorcontrib><creatorcontrib>HANSON, ROBERT P.</creatorcontrib><title>TRANSMISSIBLE MINK ENCEPHALOPATHY IN CARNIVORES: CLINICAL, LIGHT AND ELECTRON MICROSCOPIC STUDIES IN RACCONS, SKUNKS AND FERRETS</title><title>Journal of wildlife diseases</title><addtitle>J Wildl Dis</addtitle><description>Four raccoons and one of two skunks inoculated with brain suspensions containing the transmissible mink encephalopathy (TME) agent developed a neurologic disease characterized by alterations of behavior, by incoordination and by slowing of motor activity. Histologic examination of the brains revealed a spongiform polioencephalopathy as is characteristic of the disease in mink. Fourteen ferrets inoculated with TME brain suspensions remained asymptomatic until sacrifice 2 years post-inoculation. A spongiform degeneration of gray matter was present in all ferret brains. However, the lesions and their topographical distribution were distinctly different from those seen in the brains of all other species susceptible to TME infection.</description><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Brain - pathology</subject><subject>Brain Diseases - complications</subject><subject>Brain Diseases - microbiology</subject><subject>Brain Diseases - pathology</subject><subject>Brain Diseases - veterinary</subject><subject>Carnivora</subject><subject>Female</subject><subject>Male</subject><subject>Maternal-Fetal Exchange</subject><subject>Microscopy, Electron</subject><subject>Mink</subject><subject>Movement Disorders - etiology</subject><subject>Movement Disorders - veterinary</subject><subject>Pregnancy</subject><subject>Raccoons</subject><subject>Virus Diseases - microbiology</subject><subject>Virus Diseases - pathology</subject><subject>Virus Diseases - veterinary</subject><subject>Viruses, Unclassified</subject><issn>0090-3558</issn><issn>1943-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1u2zAQhImgReqkeYAeCvBQ9BQ5_LEksjeVYWLCCmWIcoGeCEqmGxVylEgxjNzy6JVqI732tFjMfLPYAeATRtM4ZPwKIY4CGoYs4FM6JYSfgAnmMxrQGKF3YPKmfwBnff8bIRIOyyk4nWEexxhPwGuRJ9rcKWPU91TCO6UXUGohl_MkzZZJMf8JlYYiybX6keXSfIMiVVqJJL2EqbqdFzDR11CmUhR5pgde5JkR2VIJaIrVtZJm5PNEiEybS2gWK70wf5kbmeeyMB_B-41ren9xnOdgdSMLMQ_S7HY8E5SEoeeAxMS5ON5Q4iLEI4pZycK1C0mIPEVhRWLMHPMuitZVhMvKu3L4kOFZST1Goafn4Osh97Frn3a-f7bbuq9807gH3-56yzCPIk7YYMQHY9W1fd_5jX3s6q3rXixGdmzdjq3asVXLLbVD6wPz-Ri-K7d-_UYcax70Lwf9vv51v687b_uta5rBTex-v_8Xc3WwlXXbPvj_OPwH8miNIQ</recordid><startdate>197307</startdate><enddate>197307</enddate><creator>ECKROADE, ROBERT J.</creator><creator>ZuRHEIN, GABRIELE M.</creator><creator>HANSON, ROBERT P.</creator><general>Wildlife Disease Association</general><general>Wildlife Dis Assoc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197307</creationdate><title>TRANSMISSIBLE MINK ENCEPHALOPATHY IN CARNIVORES: CLINICAL, LIGHT AND ELECTRON MICROSCOPIC STUDIES IN RACCONS, SKUNKS AND FERRETS</title><author>ECKROADE, ROBERT J. ; ZuRHEIN, GABRIELE M. ; HANSON, ROBERT P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b280t-272aa77f32a6096318b85da5250e305c2718a8ea66dc61bceab977814b3e105e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Brain - pathology</topic><topic>Brain Diseases - complications</topic><topic>Brain Diseases - microbiology</topic><topic>Brain Diseases - pathology</topic><topic>Brain Diseases - veterinary</topic><topic>Carnivora</topic><topic>Female</topic><topic>Male</topic><topic>Maternal-Fetal Exchange</topic><topic>Microscopy, Electron</topic><topic>Mink</topic><topic>Movement Disorders - etiology</topic><topic>Movement Disorders - veterinary</topic><topic>Pregnancy</topic><topic>Raccoons</topic><topic>Virus Diseases - microbiology</topic><topic>Virus Diseases - pathology</topic><topic>Virus Diseases - veterinary</topic><topic>Viruses, Unclassified</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ECKROADE, ROBERT J.</creatorcontrib><creatorcontrib>ZuRHEIN, GABRIELE M.</creatorcontrib><creatorcontrib>HANSON, ROBERT P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of wildlife diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ECKROADE, ROBERT J.</au><au>ZuRHEIN, GABRIELE M.</au><au>HANSON, ROBERT P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TRANSMISSIBLE MINK ENCEPHALOPATHY IN CARNIVORES: CLINICAL, LIGHT AND ELECTRON MICROSCOPIC STUDIES IN RACCONS, SKUNKS AND FERRETS</atitle><jtitle>Journal of wildlife diseases</jtitle><addtitle>J Wildl Dis</addtitle><date>1973-07</date><risdate>1973</risdate><volume>9</volume><issue>3</issue><spage>229</spage><epage>240</epage><pages>229-240</pages><issn>0090-3558</issn><eissn>1943-3700</eissn><abstract>Four raccoons and one of two skunks inoculated with brain suspensions containing the transmissible mink encephalopathy (TME) agent developed a neurologic disease characterized by alterations of behavior, by incoordination and by slowing of motor activity. Histologic examination of the brains revealed a spongiform polioencephalopathy as is characteristic of the disease in mink. Fourteen ferrets inoculated with TME brain suspensions remained asymptomatic until sacrifice 2 years post-inoculation. A spongiform degeneration of gray matter was present in all ferret brains. However, the lesions and their topographical distribution were distinctly different from those seen in the brains of all other species susceptible to TME infection.</abstract><cop>United States</cop><pub>Wildlife Disease Association</pub><pmid>4197711</pmid><doi>10.7589/0090-3558-9.3.229</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-3558 |
| ispartof | Journal of wildlife diseases, 1973-07, Vol.9 (3), p.229-240 |
| issn | 0090-3558 1943-3700 |
| language | eng |
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| source | MEDLINE; BioOne Open Access Titles; Allen Press Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Behavior, Animal Brain - pathology Brain Diseases - complications Brain Diseases - microbiology Brain Diseases - pathology Brain Diseases - veterinary Carnivora Female Male Maternal-Fetal Exchange Microscopy, Electron Mink Movement Disorders - etiology Movement Disorders - veterinary Pregnancy Raccoons Virus Diseases - microbiology Virus Diseases - pathology Virus Diseases - veterinary Viruses, Unclassified |
| title | TRANSMISSIBLE MINK ENCEPHALOPATHY IN CARNIVORES: CLINICAL, LIGHT AND ELECTRON MICROSCOPIC STUDIES IN RACCONS, SKUNKS AND FERRETS |
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