The spontaneous occurrence of apoptosis in squamous carcinomas of the uterine cervix
A distinctive type of individual ceil necrosis occurring in squamous carcinomas of the uterine cervix has been studied by light and electron microscopy. The first stage of the process involves condensation and fragmentation of scattered tumour cells with the production of compact, membrane-bounded b...
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| Veröffentlicht in: | Pathology 1973-01, Vol.5 (2), p.163-169 |
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| container_title | Pathology |
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| creator | Searle, J. Collins, D.J. Harmon, B. Kerr, J.F.R. |
| description | A distinctive type of individual ceil necrosis occurring in squamous carcinomas of the uterine cervix has been studied by light and electron microscopy. The first stage of the process involves condensation and fragmentation of scattered tumour cells with the production of compact, membrane-bounded bodies in which organelles appear well preserved. These are then phagocytosed by either neoplastic epithelial cells or histiocytes, and are degraded by lysosomal hydrolases. The phenomenon is identical with shrinkage necrosis or apoptosis, which has been described in non-neoplastic tissues under both physiological and pathological conditions, and in several other neoplasms. The findings indicate that cell loss by this means is often considerable in cervical carcinomas, and are consistent with the hypothesis that the spontaneous occurrence of apoptosis might largely account for the discrepancy known to exist between the rate of cell multiplication in malignant tumours and their rate of growth. |
| doi_str_mv | 10.3109/00313027309060831 |
| format | Article |
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The first stage of the process involves condensation and fragmentation of scattered tumour cells with the production of compact, membrane-bounded bodies in which organelles appear well preserved. These are then phagocytosed by either neoplastic epithelial cells or histiocytes, and are degraded by lysosomal hydrolases. The phenomenon is identical with shrinkage necrosis or apoptosis, which has been described in non-neoplastic tissues under both physiological and pathological conditions, and in several other neoplasms. The findings indicate that cell loss by this means is often considerable in cervical carcinomas, and are consistent with the hypothesis that the spontaneous occurrence of apoptosis might largely account for the discrepancy known to exist between the rate of cell multiplication in malignant tumours and their rate of growth.</description><identifier>ISSN: 0031-3025</identifier><identifier>EISSN: 1465-3931</identifier><identifier>DOI: 10.3109/00313027309060831</identifier><identifier>PMID: 4718080</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Acid Phosphatase - analysis ; Biopsy ; Carcinoma, Squamous Cell - enzymology ; Carcinoma, Squamous Cell - pathology ; Cervix Uteri - pathology ; Epithelial Cells ; Female ; Histiocytes ; Histocytochemistry ; Humans ; Lysosomes - enzymology ; Microscopy, Electron ; Necrosis - enzymology ; Necrosis - pathology ; Organoids ; Phagocytosis ; Uterine Cervical Neoplasms - enzymology ; Uterine Cervical Neoplasms - pathology</subject><ispartof>Pathology, 1973-01, Vol.5 (2), p.163-169</ispartof><rights>1973 Royal College of Pathologists of Australasia</rights><rights>1973 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1973</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-d44c0d86984ffd48aca0fe16d0e7bd2c4c723210cbb0302f07f8b0c959665c4b3</citedby><cites>FETCH-LOGICAL-c466t-d44c0d86984ffd48aca0fe16d0e7bd2c4c723210cbb0302f07f8b0c959665c4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00313027309060831$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00313027309060831$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>315,781,785,27928,27929,61225,61406</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4718080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Searle, J.</creatorcontrib><creatorcontrib>Collins, D.J.</creatorcontrib><creatorcontrib>Harmon, B.</creatorcontrib><creatorcontrib>Kerr, J.F.R.</creatorcontrib><title>The spontaneous occurrence of apoptosis in squamous carcinomas of the uterine cervix</title><title>Pathology</title><addtitle>Pathology</addtitle><description>A distinctive type of individual ceil necrosis occurring in squamous carcinomas of the uterine cervix has been studied by light and electron microscopy. The first stage of the process involves condensation and fragmentation of scattered tumour cells with the production of compact, membrane-bounded bodies in which organelles appear well preserved. These are then phagocytosed by either neoplastic epithelial cells or histiocytes, and are degraded by lysosomal hydrolases. The phenomenon is identical with shrinkage necrosis or apoptosis, which has been described in non-neoplastic tissues under both physiological and pathological conditions, and in several other neoplasms. The findings indicate that cell loss by this means is often considerable in cervical carcinomas, and are consistent with the hypothesis that the spontaneous occurrence of apoptosis might largely account for the discrepancy known to exist between the rate of cell multiplication in malignant tumours and their rate of growth.</description><subject>Acid Phosphatase - analysis</subject><subject>Biopsy</subject><subject>Carcinoma, Squamous Cell - enzymology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cervix Uteri - pathology</subject><subject>Epithelial Cells</subject><subject>Female</subject><subject>Histiocytes</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Lysosomes - enzymology</subject><subject>Microscopy, Electron</subject><subject>Necrosis - enzymology</subject><subject>Necrosis - pathology</subject><subject>Organoids</subject><subject>Phagocytosis</subject><subject>Uterine Cervical Neoplasms - enzymology</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>0031-3025</issn><issn>1465-3931</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFP3DAQhS3UCra0P4ADUk69pR2vvY4tTgi1UAmpl-VsOZOx1mgTBztB8O9xtCsuSJzm8L73pPkYu-DwS3AwvwEEF7BuBBhQoAU_YSsu1aYWRvAvbLXkdQE2Z-xbzo8AILXWp-xUNlyDhhXbbndU5TEOkxsozrmKiHNKNCBV0VdujOMUc8hVGKr8NLt-YdAlDEPsXV6YqSzME6UwUIWUnsPLd_bVu32mH8d7zh7-_tne3NX3_2__3Vzf1yiVmupOSoROK6Ol953UDh144qoDatpujRKbtVhzwLaF8oSHxusW0GyMUhuUrThnPw-7Y4pPM-XJ9iEj7feHX6zmRgmjTQH5AcQUc07k7ZhC79Kr5WAXk_aDydK5PI7PbU_de-OoruRXhzwMPqbe7cjtp11RQ_Yxzmkoj3-6fmxT8fMcKNmMYbHehUQ42S6GT9pvfOeT6w</recordid><startdate>19730101</startdate><enddate>19730101</enddate><creator>Searle, J.</creator><creator>Collins, D.J.</creator><creator>Harmon, B.</creator><creator>Kerr, J.F.R.</creator><general>Elsevier B.V</general><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19730101</creationdate><title>The spontaneous occurrence of apoptosis in squamous carcinomas of the uterine cervix</title><author>Searle, J. ; Collins, D.J. ; Harmon, B. ; Kerr, J.F.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-d44c0d86984ffd48aca0fe16d0e7bd2c4c723210cbb0302f07f8b0c959665c4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Acid Phosphatase - analysis</topic><topic>Biopsy</topic><topic>Carcinoma, Squamous Cell - enzymology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cervix Uteri - pathology</topic><topic>Epithelial Cells</topic><topic>Female</topic><topic>Histiocytes</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Lysosomes - enzymology</topic><topic>Microscopy, Electron</topic><topic>Necrosis - enzymology</topic><topic>Necrosis - pathology</topic><topic>Organoids</topic><topic>Phagocytosis</topic><topic>Uterine Cervical Neoplasms - enzymology</topic><topic>Uterine Cervical Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Searle, J.</creatorcontrib><creatorcontrib>Collins, D.J.</creatorcontrib><creatorcontrib>Harmon, B.</creatorcontrib><creatorcontrib>Kerr, J.F.R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Searle, J.</au><au>Collins, D.J.</au><au>Harmon, B.</au><au>Kerr, J.F.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The spontaneous occurrence of apoptosis in squamous carcinomas of the uterine cervix</atitle><jtitle>Pathology</jtitle><addtitle>Pathology</addtitle><date>1973-01-01</date><risdate>1973</risdate><volume>5</volume><issue>2</issue><spage>163</spage><epage>169</epage><pages>163-169</pages><issn>0031-3025</issn><eissn>1465-3931</eissn><abstract>A distinctive type of individual ceil necrosis occurring in squamous carcinomas of the uterine cervix has been studied by light and electron microscopy. The first stage of the process involves condensation and fragmentation of scattered tumour cells with the production of compact, membrane-bounded bodies in which organelles appear well preserved. These are then phagocytosed by either neoplastic epithelial cells or histiocytes, and are degraded by lysosomal hydrolases. The phenomenon is identical with shrinkage necrosis or apoptosis, which has been described in non-neoplastic tissues under both physiological and pathological conditions, and in several other neoplasms. The findings indicate that cell loss by this means is often considerable in cervical carcinomas, and are consistent with the hypothesis that the spontaneous occurrence of apoptosis might largely account for the discrepancy known to exist between the rate of cell multiplication in malignant tumours and their rate of growth.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>4718080</pmid><doi>10.3109/00313027309060831</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3025 |
| ispartof | Pathology, 1973-01, Vol.5 (2), p.163-169 |
| issn | 0031-3025 1465-3931 |
| language | eng |
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| source | MEDLINE; Access via Taylor & Francis; Alma/SFX Local Collection |
| subjects | Acid Phosphatase - analysis Biopsy Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - pathology Cervix Uteri - pathology Epithelial Cells Female Histiocytes Histocytochemistry Humans Lysosomes - enzymology Microscopy, Electron Necrosis - enzymology Necrosis - pathology Organoids Phagocytosis Uterine Cervical Neoplasms - enzymology Uterine Cervical Neoplasms - pathology |
| title | The spontaneous occurrence of apoptosis in squamous carcinomas of the uterine cervix |
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