Role of Magnesium Ion in the Initiation of Ventricular Fibrillation Produced by Acute Coronary Occlusion

Role of Magnesium Ion in the Initiation of Ventricular Fibrillation Produced by Acute Coronary Occlusion

The incidence of ventricular fibrillation following acute coronary occlusion in dogs was reduced by perfusing the ischemic area of the myocardium with Locke-Ringerʼs solution and solutions of magnesium ion in physiological saline. In contrast, normal serum concentrations of magnesium in 5 per cent d...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Circulation research 1957-07, Vol.5 (4), p.405-408
Hauptverfasser: Garden, Norman L, Steinhaus, John E
Format: Artikel
Sprache:eng
Schlagworte:
Coronary Disease
Coronary Occlusion
Heart
Humans
Magnesium - pharmacology
Old Medline
Ventricular Fibrillation
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 408
container_issue 4
container_start_page 405
container_title Circulation research
container_volume 5
creator Garden, Norman L
Steinhaus, John E
description The incidence of ventricular fibrillation following acute coronary occlusion in dogs was reduced by perfusing the ischemic area of the myocardium with Locke-Ringerʼs solution and solutions of magnesium ion in physiological saline. In contrast, normal serum concentrations of magnesium in 5 per cent dextrose appeared to induce ventricular fibrillation in these circumstances. The results suggest that changes in the concentration of magnesium and sodium ion in extracellular fluid may initiate ventricular fibrillation in the ischemic heart.
doi_str_mv 10.1161/01.res.5.4.405
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81956191</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>81956191</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4133-7b46bc061a64cfa38871eaa1d7fe78431fa9a9b77b4ca33663ce6ae7b47047c63</originalsourceid><addsrcrecordid>eNpFkctPJCEQxolxo-Pj6tFw8ta91EBD99FMfEzixo2vK6GZ6h1WplFoYvzvxcwkHiqkil99-fgg5AxYDSDhN4M6YqqbWtSCNXtkBs1cVKJRsE9mjLGuUpyzQ3KU0n_GQPB5d0AOgQuhoG1mZP0QPNIw0D_m34jJ5Q1dhpG6kU5rpMvRTc5MrkwK8oLjFJ3N3kR67frovN_e_Y1hlS2uaP9JL22ekC5CDKOJn_TeWp9TgU7Ir8H4hKe785g8X189LW6ru_ub5eLyrrICOK9UL2RvmQQjhR0Mb1sFaAys1ICqFRwG05muV4WzhnMpuUVpsLSKCWUlPyYXW923GN4zpklvXLJYrI4YctItdI2EDgpYb0EbQ0oRB_0W3aZ41sD0d7aagX64etSNFrpkWxbOd8q53-DqB9-FWQCxBT6CnzCmV58_MOo1Gj-tdfkMxhnMq2JAMVW6qlR58xfjnYVS</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81956191</pqid></control><display><type>article</type><title>Role of Magnesium Ion in the Initiation of Ventricular Fibrillation Produced by Acute Coronary Occlusion</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>Garden, Norman L ; Steinhaus, John E</creator><creatorcontrib>Garden, Norman L ; Steinhaus, John E</creatorcontrib><description>The incidence of ventricular fibrillation following acute coronary occlusion in dogs was reduced by perfusing the ischemic area of the myocardium with Locke-Ringerʼs solution and solutions of magnesium ion in physiological saline. In contrast, normal serum concentrations of magnesium in 5 per cent dextrose appeared to induce ventricular fibrillation in these circumstances. The results suggest that changes in the concentration of magnesium and sodium ion in extracellular fluid may initiate ventricular fibrillation in the ischemic heart.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.res.5.4.405</identifier><identifier>PMID: 13447185</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Coronary Disease ; Coronary Occlusion ; Heart ; Humans ; Magnesium - pharmacology ; Old Medline ; Ventricular Fibrillation</subject><ispartof>Circulation research, 1957-07, Vol.5 (4), p.405-408</ispartof><rights>1957 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4133-7b46bc061a64cfa38871eaa1d7fe78431fa9a9b77b4ca33663ce6ae7b47047c63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13447185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garden, Norman L</creatorcontrib><creatorcontrib>Steinhaus, John E</creatorcontrib><title>Role of Magnesium Ion in the Initiation of Ventricular Fibrillation Produced by Acute Coronary Occlusion</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>The incidence of ventricular fibrillation following acute coronary occlusion in dogs was reduced by perfusing the ischemic area of the myocardium with Locke-Ringerʼs solution and solutions of magnesium ion in physiological saline. In contrast, normal serum concentrations of magnesium in 5 per cent dextrose appeared to induce ventricular fibrillation in these circumstances. The results suggest that changes in the concentration of magnesium and sodium ion in extracellular fluid may initiate ventricular fibrillation in the ischemic heart.</description><subject>Coronary Disease</subject><subject>Coronary Occlusion</subject><subject>Heart</subject><subject>Humans</subject><subject>Magnesium - pharmacology</subject><subject>Old Medline</subject><subject>Ventricular Fibrillation</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1957</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkctPJCEQxolxo-Pj6tFw8ta91EBD99FMfEzixo2vK6GZ6h1WplFoYvzvxcwkHiqkil99-fgg5AxYDSDhN4M6YqqbWtSCNXtkBs1cVKJRsE9mjLGuUpyzQ3KU0n_GQPB5d0AOgQuhoG1mZP0QPNIw0D_m34jJ5Q1dhpG6kU5rpMvRTc5MrkwK8oLjFJ3N3kR67frovN_e_Y1hlS2uaP9JL22ekC5CDKOJn_TeWp9TgU7Ir8H4hKe785g8X189LW6ru_ub5eLyrrICOK9UL2RvmQQjhR0Mb1sFaAys1ICqFRwG05muV4WzhnMpuUVpsLSKCWUlPyYXW923GN4zpklvXLJYrI4YctItdI2EDgpYb0EbQ0oRB_0W3aZ41sD0d7aagX64etSNFrpkWxbOd8q53-DqB9-FWQCxBT6CnzCmV58_MOo1Gj-tdfkMxhnMq2JAMVW6qlR58xfjnYVS</recordid><startdate>195707</startdate><enddate>195707</enddate><creator>Garden, Norman L</creator><creator>Steinhaus, John E</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195707</creationdate><title>Role of Magnesium Ion in the Initiation of Ventricular Fibrillation Produced by Acute Coronary Occlusion</title><author>Garden, Norman L ; Steinhaus, John E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4133-7b46bc061a64cfa38871eaa1d7fe78431fa9a9b77b4ca33663ce6ae7b47047c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1957</creationdate><topic>Coronary Disease</topic><topic>Coronary Occlusion</topic><topic>Heart</topic><topic>Humans</topic><topic>Magnesium - pharmacology</topic><topic>Old Medline</topic><topic>Ventricular Fibrillation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garden, Norman L</creatorcontrib><creatorcontrib>Steinhaus, John E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garden, Norman L</au><au>Steinhaus, John E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Magnesium Ion in the Initiation of Ventricular Fibrillation Produced by Acute Coronary Occlusion</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1957-07</date><risdate>1957</risdate><volume>5</volume><issue>4</issue><spage>405</spage><epage>408</epage><pages>405-408</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><abstract>The incidence of ventricular fibrillation following acute coronary occlusion in dogs was reduced by perfusing the ischemic area of the myocardium with Locke-Ringerʼs solution and solutions of magnesium ion in physiological saline. In contrast, normal serum concentrations of magnesium in 5 per cent dextrose appeared to induce ventricular fibrillation in these circumstances. The results suggest that changes in the concentration of magnesium and sodium ion in extracellular fluid may initiate ventricular fibrillation in the ischemic heart.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>13447185</pmid><doi>10.1161/01.res.5.4.405</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0009-7330
ispartof Circulation research, 1957-07, Vol.5 (4), p.405-408
issn 0009-7330
1524-4571
language eng
recordid cdi_proquest_miscellaneous_81956191
source MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete
subjects Coronary Disease
Coronary Occlusion
Heart
Humans
Magnesium - pharmacology
Old Medline
Ventricular Fibrillation
title Role of Magnesium Ion in the Initiation of Ventricular Fibrillation Produced by Acute Coronary Occlusion
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T06%3A47%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20Magnesium%20Ion%20in%20the%20Initiation%20of%20Ventricular%20Fibrillation%20Produced%20by%20Acute%20Coronary%20Occlusion&rft.jtitle=Circulation%20research&rft.au=Garden,%20Norman%20L&rft.date=1957-07&rft.volume=5&rft.issue=4&rft.spage=405&rft.epage=408&rft.pages=405-408&rft.issn=0009-7330&rft.eissn=1524-4571&rft_id=info:doi/10.1161/01.res.5.4.405&rft_dat=%3Cproquest_cross%3E81956191%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81956191&rft_id=info:pmid/13447185&rfr_iscdi=true