Myelination Inhibition Factor: Its Absence in Sera from Subhuman Primates Sensitized with Myelin Basic Protein
Experimental allergic encephalomyelitis was induced in subhuman primates by inoculation with either whole monkey brain plus Freund's adjuvant or with purified bovine myelin basic protein combined with Freund's adjuvant. Sera from the whole brain-sensitized primates, when incorporated into...
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| Veröffentlicht in: | The Journal of immunology (1950) 1973-07, Vol.111 (1), p.96-100 |
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| container_title | The Journal of immunology (1950) |
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| creator | Seil, Fredrick J Rauch, Helene C Einstein, Elizabeth Roboz Hamilton, Ann E |
| description | Experimental allergic encephalomyelitis was induced in subhuman primates by inoculation with either whole monkey brain plus Freund's adjuvant or with purified bovine myelin basic protein combined with Freund's adjuvant. Sera from the whole brain-sensitized primates, when incorporated into tissue culture nutrient medium and applied continuously to cerebellar cultures from the day of explantation on, prevented the formation of myelin in the explants. Sera from basic protein-sensitized primates, on the other hand, failed to inhibit myelination when applied in like fashion to cerebellar tissue cultures, confirming a previous demonstration of a similar lack of myelination-inhibiting activity in sera from basic protein-sensitized guinea pigs. The results suggest that the tissue culture myelination inhibition factor is induced by a component of whole central nervous system tissue other than the encephalitogenic protein. |
| doi_str_mv | 10.4049/jimmunol.111.1.96 |
| format | Article |
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Sera from the whole brain-sensitized primates, when incorporated into tissue culture nutrient medium and applied continuously to cerebellar cultures from the day of explantation on, prevented the formation of myelin in the explants. Sera from basic protein-sensitized primates, on the other hand, failed to inhibit myelination when applied in like fashion to cerebellar tissue cultures, confirming a previous demonstration of a similar lack of myelination-inhibiting activity in sera from basic protein-sensitized guinea pigs. The results suggest that the tissue culture myelination inhibition factor is induced by a component of whole central nervous system tissue other than the encephalitogenic protein.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.111.1.96</identifier><identifier>PMID: 4123376</identifier><language>eng</language><publisher>United States: Am Assoc Immnol</publisher><subject>Animals ; Antigens ; Brain - immunology ; Cattle ; Encephalomyelitis, Autoimmune, Experimental - immunology ; Female ; Freund's Adjuvant ; Haplorhini ; Immunization ; Macaca ; Male ; Myelin Basic Protein ; Nerve Tissue Proteins ; Papio ; Time Factors</subject><ispartof>The Journal of immunology (1950), 1973-07, Vol.111 (1), p.96-100</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-657402074eb048c01951bce402499c480751607e9fc8cb542e4e01199653675c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4123376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seil, Fredrick J</creatorcontrib><creatorcontrib>Rauch, Helene C</creatorcontrib><creatorcontrib>Einstein, Elizabeth Roboz</creatorcontrib><creatorcontrib>Hamilton, Ann E</creatorcontrib><title>Myelination Inhibition Factor: Its Absence in Sera from Subhuman Primates Sensitized with Myelin Basic Protein</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>Experimental allergic encephalomyelitis was induced in subhuman primates by inoculation with either whole monkey brain plus Freund's adjuvant or with purified bovine myelin basic protein combined with Freund's adjuvant. 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The results suggest that the tissue culture myelination inhibition factor is induced by a component of whole central nervous system tissue other than the encephalitogenic protein.</description><subject>Animals</subject><subject>Antigens</subject><subject>Brain - immunology</subject><subject>Cattle</subject><subject>Encephalomyelitis, Autoimmune, Experimental - immunology</subject><subject>Female</subject><subject>Freund's Adjuvant</subject><subject>Haplorhini</subject><subject>Immunization</subject><subject>Macaca</subject><subject>Male</subject><subject>Myelin Basic Protein</subject><subject>Nerve Tissue Proteins</subject><subject>Papio</subject><subject>Time Factors</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9v1DAQxS0EKkvhA3BA8gVuWWYS_1lzK1ULKxW1UuFsOe4scZU4xU4UlU9fL7v0NKN57_2keYy9R1gLEObzfRiGOY79GhHXuDbqBVuhlFApBeolWwHUdYVa6dfsTc73AKCgFifsRGDdNFqtWPzxSH2Ibgpj5NvYhTb8Wy-dn8b0hW-nzM_aTNETD5HfUnJ8l8aB385tNw8u8psUBjdRLlrMJfyX7vgSpo4fyPyry8EX1zhRiG_Zq53rM707zlP26_Li5_n36ur62_b87KryjTJTpaQWUIMW1ILYeEAjsfVUbsIYLzagJSrQZHZ-41spahIEiMYo2SgtfXPKPh24D2n8M1Oe7BCyp753kcY5200hCi1VMeLB6NOYc6Kdfdj_kx4tgt13bP93bEvHFq3ZZz4c4XM70N1z4lhq0T8e9C787paQyObB9X1xo12W5ZnzBIKthng</recordid><startdate>197307</startdate><enddate>197307</enddate><creator>Seil, Fredrick J</creator><creator>Rauch, Helene C</creator><creator>Einstein, Elizabeth Roboz</creator><creator>Hamilton, Ann E</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197307</creationdate><title>Myelination Inhibition Factor: Its Absence in Sera from Subhuman Primates Sensitized with Myelin Basic Protein</title><author>Seil, Fredrick J ; Rauch, Helene C ; Einstein, Elizabeth Roboz ; Hamilton, Ann E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-657402074eb048c01951bce402499c480751607e9fc8cb542e4e01199653675c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Brain - immunology</topic><topic>Cattle</topic><topic>Encephalomyelitis, Autoimmune, Experimental - immunology</topic><topic>Female</topic><topic>Freund's Adjuvant</topic><topic>Haplorhini</topic><topic>Immunization</topic><topic>Macaca</topic><topic>Male</topic><topic>Myelin Basic Protein</topic><topic>Nerve Tissue Proteins</topic><topic>Papio</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seil, Fredrick J</creatorcontrib><creatorcontrib>Rauch, Helene C</creatorcontrib><creatorcontrib>Einstein, Elizabeth Roboz</creatorcontrib><creatorcontrib>Hamilton, Ann E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seil, Fredrick J</au><au>Rauch, Helene C</au><au>Einstein, Elizabeth Roboz</au><au>Hamilton, Ann E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myelination Inhibition Factor: Its Absence in Sera from Subhuman Primates Sensitized with Myelin Basic Protein</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1973-07</date><risdate>1973</risdate><volume>111</volume><issue>1</issue><spage>96</spage><epage>100</epage><pages>96-100</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>Experimental allergic encephalomyelitis was induced in subhuman primates by inoculation with either whole monkey brain plus Freund's adjuvant or with purified bovine myelin basic protein combined with Freund's adjuvant. 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| ispartof | The Journal of immunology (1950), 1973-07, Vol.111 (1), p.96-100 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antigens Brain - immunology Cattle Encephalomyelitis, Autoimmune, Experimental - immunology Female Freund's Adjuvant Haplorhini Immunization Macaca Male Myelin Basic Protein Nerve Tissue Proteins Papio Time Factors |
| title | Myelination Inhibition Factor: Its Absence in Sera from Subhuman Primates Sensitized with Myelin Basic Protein |
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