Genetic Influence on the Renin-Angiotensin System: LOW RENIN ACTIVITIES IN HYPERTENSION-PRONE RATS
Two strains of rats with opposite, genetically determined predispositions to hypertension were compared. Rats from the hypertension-prone strain had significantly lower plasma and kidney renin activities than did rats from the hypertension-resistant strain. Although renin activities were modified by...
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| Veröffentlicht in: | Circulation research 1973-06, Vol.32 (6), p.678-684 |
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| container_title | Circulation research |
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| creator | IWAI, JUNICHI DAHL, LEWIS K KNUDSEN, KNUD D |
| description | Two strains of rats with opposite, genetically determined predispositions to hypertension were compared. Rats from the hypertension-prone strain had significantly lower plasma and kidney renin activities than did rats from the hypertension-resistant strain. Although renin activities were modified by NaCl intake and blood pressure, significant differences between the two strains were present with all four experimental regimens usedlow-NaCl diet, high-NaCl diet, unilateral renal artery constriction, and unilateral renal artery constriction plus contralateral nephrectomy. Therefore, we concluded that renin activities along with blood pressure were modified by genetic influences in these two strains of rats. |
| doi_str_mv | 10.1161/01.RES.32.6.678 |
| format | Article |
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Rats from the hypertension-prone strain had significantly lower plasma and kidney renin activities than did rats from the hypertension-resistant strain. Although renin activities were modified by NaCl intake and blood pressure, significant differences between the two strains were present with all four experimental regimens usedlow-NaCl diet, high-NaCl diet, unilateral renal artery constriction, and unilateral renal artery constriction plus contralateral nephrectomy. 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Therefore, we concluded that renin activities along with blood pressure were modified by genetic influences in these two strains of rats.</description><subject>Angiotensin II - analysis</subject><subject>Animals</subject><subject>Blood Pressure</subject><subject>Hypertension - etiology</subject><subject>Hypertension - genetics</subject><subject>Kidney - analysis</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - physiopathology</subject><subject>Rats</subject><subject>Renin - analysis</subject><subject>Renin - metabolism</subject><subject>Sodium Chloride - pharmacology</subject><subject>Statistics as Topic</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUFvm0AQhVdVq9RNe-6p0p56WzLDsiz0Zlk0QbJwBKhVTytYj2tavKQsKMq_L4mtnEYz783o6RvGPiMEiDHeAAZlVgUyDOIg1skbtkIVRiJSGt-yFQCkQksJ79kH7_8AYCTD9IpdRVKhjtWKtbfkaOosz92hn8lZ4oPj05F4Sa5zYu1-d8NEzneOV09-otM3vt395GVW5AVfb-r8R17nWcWX7u7XfVbWWVHlu0Lcl7si4-W6rj6yd4em9_TpUq9Z_T2rN3diu7vNN-utsDLUUiTtPiRrATXJPaGNUiRFB4sEtlVp0iQSW2ojkNDqJG61JG1tZJNGNRgqec2-ns8-jMO_mfxkTp231PeNo2H2JsFUQQywGG_ORjsO3o90MA9jd2rGJ4NgnqEaQLNANTI0sVmgLhtfLqfn9kT7V_-F4qJHZ_1x6Cca_d9-fqTRHKnpp6NZnrBkxlBgquVzAhAvI_kfVmJ-cw</recordid><startdate>197306</startdate><enddate>197306</enddate><creator>IWAI, JUNICHI</creator><creator>DAHL, LEWIS K</creator><creator>KNUDSEN, KNUD D</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197306</creationdate><title>Genetic Influence on the Renin-Angiotensin System: LOW RENIN ACTIVITIES IN HYPERTENSION-PRONE RATS</title><author>IWAI, JUNICHI ; DAHL, LEWIS K ; KNUDSEN, KNUD D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3273-8bd2ecc017e3de1c491e5efc1e0cb598a831beb4030b786b73e7cc4c8a5a1253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Angiotensin II - analysis</topic><topic>Animals</topic><topic>Blood Pressure</topic><topic>Hypertension - etiology</topic><topic>Hypertension - genetics</topic><topic>Kidney - analysis</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney - physiopathology</topic><topic>Rats</topic><topic>Renin - analysis</topic><topic>Renin - metabolism</topic><topic>Sodium Chloride - pharmacology</topic><topic>Statistics as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IWAI, JUNICHI</creatorcontrib><creatorcontrib>DAHL, LEWIS K</creatorcontrib><creatorcontrib>KNUDSEN, KNUD D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IWAI, JUNICHI</au><au>DAHL, LEWIS K</au><au>KNUDSEN, KNUD D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Influence on the Renin-Angiotensin System: LOW RENIN ACTIVITIES IN HYPERTENSION-PRONE RATS</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1973-06</date><risdate>1973</risdate><volume>32</volume><issue>6</issue><spage>678</spage><epage>684</epage><pages>678-684</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><abstract>Two strains of rats with opposite, genetically determined predispositions to hypertension were compared. 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| fulltext | fulltext |
| identifier | ISSN: 0009-7330 |
| ispartof | Circulation research, 1973-06, Vol.32 (6), p.678-684 |
| issn | 0009-7330 1524-4571 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81950600 |
| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Angiotensin II - analysis Animals Blood Pressure Hypertension - etiology Hypertension - genetics Kidney - analysis Kidney - drug effects Kidney - metabolism Kidney - physiopathology Rats Renin - analysis Renin - metabolism Sodium Chloride - pharmacology Statistics as Topic |
| title | Genetic Influence on the Renin-Angiotensin System: LOW RENIN ACTIVITIES IN HYPERTENSION-PRONE RATS |
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