METABOLISM OF HALOTHANE DURING AND AFTER ANAESTHESIA IN MAN
The metabolism of halothane during and after anaesthesia was studied in eight patients of different age and body weight by estimating the concentration of halothane and one of its metabolites (bromide) in the blood. A gas chromatograph with an electron capture detector was used to estimate halothane...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1973-05, Vol.45 (5), p.464-470 |
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| container_end_page | 470 |
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| container_issue | 5 |
| container_start_page | 464 |
| container_title | British journal of anaesthesia : BJA |
| container_volume | 45 |
| creator | ATALLAH, M.M. GEDDES, I.C. |
| description | The metabolism of halothane during and after anaesthesia was studied in eight patients of different age and body weight by estimating the concentration of halothane and one of its metabolites (bromide) in the blood. A gas chromatograph with an electron capture detector was used to estimate halothane, while blood bromide levels were measured by neutron activation analysis. There was an initial burst of bromide production during 20 minutes of halothane administration. Bromide levels then fell, but not to control levels, and remained so until the recovery of the patient from anaesthesia. In the postanaesthetic period, bromide production took place on a larger scale than before. |
| doi_str_mv | 10.1093/bja/45.5.464 |
| format | Article |
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A gas chromatograph with an electron capture detector was used to estimate halothane, while blood bromide levels were measured by neutron activation analysis. There was an initial burst of bromide production during 20 minutes of halothane administration. Bromide levels then fell, but not to control levels, and remained so until the recovery of the patient from anaesthesia. In the postanaesthetic period, bromide production took place on a larger scale than before.</description><subject>Age Factors</subject><subject>Anesthesia</subject><subject>Body Weight</subject><subject>Bromides - administration & dosage</subject><subject>Bromides - blood</subject><subject>Bromides - metabolism</subject><subject>Female</subject><subject>Halothane - blood</subject><subject>Halothane - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Respiration - drug effects</subject><subject>Spirometry</subject><subject>Time Factors</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9r2zAYhkVZ6dIft10HPu1Up5IlWRY7aYlTeyQOJG4ZvQhJ_gzOkiazkrH-91VJyGmn74X34eXjQegLwUOCJX2wK_PA-JAPWcou0IAwQeJUCPIJDTDGIsaSJJ_RtfcrjIlIJL9CV4HhXNIB-j7La_VjPi2Xs2g-iQo1ndeFqvJo_LQoq8dIVeNITep8EZLKl3WRL0sVlVU0U9UtumzN2sPd6d6gp0lej4p4On8sR2oaO4blPqaZaZtMCkEbQ5xoDE0cZxYgFTjFLsHC2gRaKyUniRVZC9hZKloghFlpKL1B3467u3775wB-rzedd7Bem1fYHrzOiGRZkuEA3h9B12-976HVu77bmP5NE6w_XOngSjOuuQ6uAv71tHuwG2jO8ElO6ONj3_k9_DvXpv-tU0EF18WvF_3zeZkukmqsXwKfHnkIMv520GvvOnh10HQ9uL1utt3_H3kHQleALg</recordid><startdate>197305</startdate><enddate>197305</enddate><creator>ATALLAH, M.M.</creator><creator>GEDDES, I.C.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197305</creationdate><title>METABOLISM OF HALOTHANE DURING AND AFTER ANAESTHESIA IN MAN</title><author>ATALLAH, M.M. ; GEDDES, I.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-38afd89773da1c7da32c54bee67060c207bb2efb99512b78fe0cb37fe114b9a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Age Factors</topic><topic>Anesthesia</topic><topic>Body Weight</topic><topic>Bromides - administration & dosage</topic><topic>Bromides - blood</topic><topic>Bromides - metabolism</topic><topic>Female</topic><topic>Halothane - blood</topic><topic>Halothane - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Respiration - drug effects</topic><topic>Spirometry</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ATALLAH, M.M.</creatorcontrib><creatorcontrib>GEDDES, I.C.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ATALLAH, M.M.</au><au>GEDDES, I.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>METABOLISM OF HALOTHANE DURING AND AFTER ANAESTHESIA IN MAN</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>1973-05</date><risdate>1973</risdate><volume>45</volume><issue>5</issue><spage>464</spage><epage>470</epage><pages>464-470</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><abstract>The metabolism of halothane during and after anaesthesia was studied in eight patients of different age and body weight by estimating the concentration of halothane and one of its metabolites (bromide) in the blood. 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| fulltext | fulltext |
| identifier | ISSN: 0007-0912 |
| ispartof | British journal of anaesthesia : BJA, 1973-05, Vol.45 (5), p.464-470 |
| issn | 0007-0912 1471-6771 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals Digital Archive Legacy; Alma/SFX Local Collection |
| subjects | Age Factors Anesthesia Body Weight Bromides - administration & dosage Bromides - blood Bromides - metabolism Female Halothane - blood Halothane - metabolism Humans Male Respiration - drug effects Spirometry Time Factors |
| title | METABOLISM OF HALOTHANE DURING AND AFTER ANAESTHESIA IN MAN |
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