The influence of duration of protein synthesis inhibition on memory
Anisomycin and cycloheximide were compared as inhibitors of cerebral protein synthesis and as amnestic agents in mice. Anisomycin is an effective, nontoxic inhibitor of cerebral protein synthesis. Cycloheximide, while also an effective inhibitor of cerebral protein synthesis, is far more toxic. Succ...
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| Veröffentlicht in: | Physiology & behavior 1973-03, Vol.10 (3), p.555-562 |
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| container_title | Physiology & behavior |
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| creator | Flood, James F. Rosenzweig, Mark R. Bennett, Edward L. Orme, Ann E. |
| description | Anisomycin and cycloheximide were compared as inhibitors of cerebral protein synthesis and as amnestic agents in mice. Anisomycin is an effective, nontoxic inhibitor of cerebral protein synthesis. Cycloheximide, while also an effective inhibitor of cerebral protein synthesis, is far more toxic. Successive injections of anisomycin permit variation of duration of inhibition from 2–8 hr. With C57B1/Jf mice trained in passive avoidance, the longer the inhibition, the greater the percentage of amnestic subjects. The greater the training strength, the less the amnesia. Evidence indicates that cycloheximide impairs acquisition. |
| doi_str_mv | 10.1016/0031-9384(73)90221-7 |
| format | Article |
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Anisomycin is an effective, nontoxic inhibitor of cerebral protein synthesis. Cycloheximide, while also an effective inhibitor of cerebral protein synthesis, is far more toxic. Successive injections of anisomycin permit variation of duration of inhibition from 2–8 hr. With C57B1/Jf mice trained in passive avoidance, the longer the inhibition, the greater the percentage of amnestic subjects. The greater the training strength, the less the amnesia. Evidence indicates that cycloheximide impairs acquisition.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/0031-9384(73)90221-7</identifier><identifier>PMID: 4736141</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amnesia ; Amnesia - metabolism ; Animals ; Anisomycin ; Anti-Bacterial Agents - pharmacology ; Avoidance Learning ; Benzyl Compounds - pharmacology ; Brain - drug effects ; Brain - metabolism ; Cycloheximide ; Cycloheximide - pharmacology ; Dose-Response Relationship, Drug ; Electroshock ; Female ; Humans ; Memory ; Memory - drug effects ; Mice ; Mice, Inbred C57BL ; Nerve Tissue Proteins - biosynthesis ; Passive avoidance ; Protein inhibition ; Protein inhibition and amnesia ; Pyrrolidines - pharmacology ; Training parameters and memory</subject><ispartof>Physiology & behavior, 1973-03, Vol.10 (3), p.555-562</ispartof><rights>1972</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-7e20d6e40aecb970310e4ba880ba70e7b92464eb5b8acb26ff44c482dcfdc2293</citedby><cites>FETCH-LOGICAL-c469t-7e20d6e40aecb970310e4ba880ba70e7b92464eb5b8acb26ff44c482dcfdc2293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0031938473902217$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4736141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flood, James F.</creatorcontrib><creatorcontrib>Rosenzweig, Mark R.</creatorcontrib><creatorcontrib>Bennett, Edward L.</creatorcontrib><creatorcontrib>Orme, Ann E.</creatorcontrib><title>The influence of duration of protein synthesis inhibition on memory</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>Anisomycin and cycloheximide were compared as inhibitors of cerebral protein synthesis and as amnestic agents in mice. Anisomycin is an effective, nontoxic inhibitor of cerebral protein synthesis. Cycloheximide, while also an effective inhibitor of cerebral protein synthesis, is far more toxic. Successive injections of anisomycin permit variation of duration of inhibition from 2–8 hr. With C57B1/Jf mice trained in passive avoidance, the longer the inhibition, the greater the percentage of amnestic subjects. The greater the training strength, the less the amnesia. Evidence indicates that cycloheximide impairs acquisition.</description><subject>Amnesia</subject><subject>Amnesia - metabolism</subject><subject>Animals</subject><subject>Anisomycin</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Avoidance Learning</subject><subject>Benzyl Compounds - pharmacology</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Cycloheximide</subject><subject>Cycloheximide - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electroshock</subject><subject>Female</subject><subject>Humans</subject><subject>Memory</subject><subject>Memory - drug effects</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Nerve Tissue Proteins - biosynthesis</subject><subject>Passive avoidance</subject><subject>Protein inhibition</subject><subject>Protein inhibition and amnesia</subject><subject>Pyrrolidines - pharmacology</subject><subject>Training parameters and memory</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMo4zj6BgpdiS6quU3TbAQZvMGAmxHchSQ9ZSK9jEkr9O1N7TBLz-Yc-P9z-xC6JPiOYJLdY8xIKlnObwS7lZhSkoojNCe5YOkSi89jND9YTtFZCF84BuNshmZcsIxwMkerzRYS15RVD42FpC2Tove6c20z1jvfduCaJAxNt4XgQrRunXGT3iQ11K0fztFJqasAF_u8QB_PT5vVa7p-f3lbPa5TyzPZpQIoLjLgWIM1UsTTMHCj8xwbLTAIIynPOJilybU1NCtLzi3PaWHLwlIq2QJdT3PjWd89hE7VLlioKt1A2weVE8kk5lk08slofRuCh1LtvKu1HxTBamSnRjBqBKMEU3_sYrFAV_v5vamhODTtYUX9YdIhPvnjwKtg3YitcB5sp4rW_b_gF52XfmA</recordid><startdate>197303</startdate><enddate>197303</enddate><creator>Flood, James F.</creator><creator>Rosenzweig, Mark R.</creator><creator>Bennett, Edward L.</creator><creator>Orme, Ann E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197303</creationdate><title>The influence of duration of protein synthesis inhibition on memory</title><author>Flood, James F. ; Rosenzweig, Mark R. ; Bennett, Edward L. ; Orme, Ann E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-7e20d6e40aecb970310e4ba880ba70e7b92464eb5b8acb26ff44c482dcfdc2293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Amnesia</topic><topic>Amnesia - metabolism</topic><topic>Animals</topic><topic>Anisomycin</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Avoidance Learning</topic><topic>Benzyl Compounds - pharmacology</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Cycloheximide</topic><topic>Cycloheximide - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electroshock</topic><topic>Female</topic><topic>Humans</topic><topic>Memory</topic><topic>Memory - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nerve Tissue Proteins - biosynthesis</topic><topic>Passive avoidance</topic><topic>Protein inhibition</topic><topic>Protein inhibition and amnesia</topic><topic>Pyrrolidines - pharmacology</topic><topic>Training parameters and memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flood, James F.</creatorcontrib><creatorcontrib>Rosenzweig, Mark R.</creatorcontrib><creatorcontrib>Bennett, Edward L.</creatorcontrib><creatorcontrib>Orme, Ann E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flood, James F.</au><au>Rosenzweig, Mark R.</au><au>Bennett, Edward L.</au><au>Orme, Ann E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of duration of protein synthesis inhibition on memory</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1973-03</date><risdate>1973</risdate><volume>10</volume><issue>3</issue><spage>555</spage><epage>562</epage><pages>555-562</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>Anisomycin and cycloheximide were compared as inhibitors of cerebral protein synthesis and as amnestic agents in mice. Anisomycin is an effective, nontoxic inhibitor of cerebral protein synthesis. Cycloheximide, while also an effective inhibitor of cerebral protein synthesis, is far more toxic. Successive injections of anisomycin permit variation of duration of inhibition from 2–8 hr. With C57B1/Jf mice trained in passive avoidance, the longer the inhibition, the greater the percentage of amnestic subjects. The greater the training strength, the less the amnesia. Evidence indicates that cycloheximide impairs acquisition.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>4736141</pmid><doi>10.1016/0031-9384(73)90221-7</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Physiology & behavior, 1973-03, Vol.10 (3), p.555-562 |
| issn | 0031-9384 1873-507X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amnesia Amnesia - metabolism Animals Anisomycin Anti-Bacterial Agents - pharmacology Avoidance Learning Benzyl Compounds - pharmacology Brain - drug effects Brain - metabolism Cycloheximide Cycloheximide - pharmacology Dose-Response Relationship, Drug Electroshock Female Humans Memory Memory - drug effects Mice Mice, Inbred C57BL Nerve Tissue Proteins - biosynthesis Passive avoidance Protein inhibition Protein inhibition and amnesia Pyrrolidines - pharmacology Training parameters and memory |
| title | The influence of duration of protein synthesis inhibition on memory |
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