Stabilization of heterogeneous nuclear RNA by intercalating drugs

The effect of the intercalating drugs proflavine, ethidium and daunomycin on the rate of degradation of 14C-labeled heterogeneous nuclear RNA (HnRNA) in KB cells was studied. All three drugs decreased the rate of degradation of 14C-HnRNA to acid soluble products. The most striking effect was produce...

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Veröffentlicht in:	Biochemical and biophysical research communications 1973-06, Vol.52 (3), p.928-934
Hauptverfasser:	Brinker, Jane M., Madore, H.Paul, Bello, Leonard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - pharmacology Amines - pharmacology Binding Sites Carbon Isotopes Carcinoma Cell Line Cycloheximide - pharmacology Dactinomycin - pharmacology Daunorubicin - pharmacology Drug Stability Ethidium - pharmacology Humans Kinetics Mouth Neoplasms Nucleic Acid Conformation Nucleic Acid Denaturation Phenanthridines - pharmacology RNA, Neoplasm - metabolism
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