Histamine: Effect on Self-Stimulation
When injected discretely into the lateral hypothalamus of rats, histamine inhibited electrical self-stimulation at the injection site without affecting self-stimulation in the contralateral lateral hypothalamus. This effect was blocked by prior treatment with antihistaminics. Histidine, the amino ac...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1973-05, Vol.180 (4087), p.757-758 |
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| container_end_page | 758 |
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| container_issue | 4087 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 180 |
| creator | Cohn, Cal K. Ball, Gordon G. Hirsch, Jules |
| description | When injected discretely into the lateral hypothalamus of rats, histamine inhibited electrical self-stimulation at the injection site without affecting self-stimulation in the contralateral lateral hypothalamus. This effect was blocked by prior treatment with antihistaminics. Histidine, the amino acid precursor of histamine, produced a similar effect after a delay of 6 to 10 minutes. |
| doi_str_mv | 10.1126/science.180.4087.757 |
| format | Article |
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This effect was blocked by prior treatment with antihistaminics. 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This effect was blocked by prior treatment with antihistaminics. Histidine, the amino acid precursor of histamine, produced a similar effect after a delay of 6 to 10 minutes.</description><subject>Animals</subject><subject>Antihistaminics</subject><subject>Catheterization</subject><subject>Dosage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electrodes</subject><subject>Histamine - administration & dosage</subject><subject>Histamine - pharmacology</subject><subject>Histamine H1 Antagonists - pharmacology</subject><subject>Histamines</subject><subject>Histidine - pharmacology</subject><subject>Hypothalamus</subject><subject>Hypothalamus - drug effects</subject><subject>Perception</subject><subject>Rats</subject><subject>Self Stimulation - drug effects</subject><subject>Stereotaxic Techniques</subject><subject>Threshing</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtKw0AUhgdRaq2-QYVudJd45paZuJNSrVBwUV0Pk7lASi41M1n49k5p0NX54b9w-BBaYsgxJsVTMLXrjMuxhJyBFLng4gLNMZQ8KwnQSzQHoEUmQfBrdBPCASB5JZ2hGcOMA5A5etjWIeq27tzzauO9M3HVd6u9a3y2j3U7NjrWfXeLrrxugrub7gJ9vW4-19ts9_H2vn7ZZYZyGjML1nPKK1uRsqi4tLZihQaLDa0I6PS19FokRb2mxhBmBGOaaMc5Z8JwukCP593j0H-PLkTV1sG4ptGd68egJC4xCCZSkJ2DZuhDGJxXx6Fu9fCjMKgTHTXRUYmOOtFRiU6q3U_7Y9U6-1eacCR_efYPIfbD_6agRYkl_QVHpmpW</recordid><startdate>19730518</startdate><enddate>19730518</enddate><creator>Cohn, Cal K.</creator><creator>Ball, Gordon G.</creator><creator>Hirsch, Jules</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19730518</creationdate><title>Histamine: Effect on Self-Stimulation</title><author>Cohn, Cal K. ; Ball, Gordon G. ; Hirsch, Jules</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-d0df535bdb296b58ddb46a0d1c3b20a1128fa720a3fa3cc24c744a2ae55547c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Antihistaminics</topic><topic>Catheterization</topic><topic>Dosage</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electrodes</topic><topic>Histamine - administration & dosage</topic><topic>Histamine - pharmacology</topic><topic>Histamine H1 Antagonists - pharmacology</topic><topic>Histamines</topic><topic>Histidine - pharmacology</topic><topic>Hypothalamus</topic><topic>Hypothalamus - drug effects</topic><topic>Perception</topic><topic>Rats</topic><topic>Self Stimulation - drug effects</topic><topic>Stereotaxic Techniques</topic><topic>Threshing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohn, Cal K.</creatorcontrib><creatorcontrib>Ball, Gordon G.</creatorcontrib><creatorcontrib>Hirsch, Jules</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohn, Cal K.</au><au>Ball, Gordon G.</au><au>Hirsch, Jules</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histamine: Effect on Self-Stimulation</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1973-05-18</date><risdate>1973</risdate><volume>180</volume><issue>4087</issue><spage>757</spage><epage>758</epage><pages>757-758</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>When injected discretely into the lateral hypothalamus of rats, histamine inhibited electrical self-stimulation at the injection site without affecting self-stimulation in the contralateral lateral hypothalamus. This effect was blocked by prior treatment with antihistaminics. Histidine, the amino acid precursor of histamine, produced a similar effect after a delay of 6 to 10 minutes.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>4145002</pmid><doi>10.1126/science.180.4087.757</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1973-05, Vol.180 (4087), p.757-758 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81910747 |
| source | Jstor Complete Legacy; MEDLINE; Science Magazine |
| subjects | Animals Antihistaminics Catheterization Dosage Dose-Response Relationship, Drug Electrodes Histamine - administration & dosage Histamine - pharmacology Histamine H1 Antagonists - pharmacology Histamines Histidine - pharmacology Hypothalamus Hypothalamus - drug effects Perception Rats Self Stimulation - drug effects Stereotaxic Techniques Threshing |
| title | Histamine: Effect on Self-Stimulation |
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