Long-term administration of progesterone to the female beagle dog

Progesterone was administered sc to groups of 5 mature female beagle dogs for 74 weeks at doses of 0.083, 0.25 or 0.75 mg/kg/day for the first 12 weeks, 0.83, 2.5 or 7.5 mg/kg/day for the next 24 weeks, and finally 2.5, 7.5 or 22.5 mg/kg/day from weeks 37 to 74. Estrus was not observed in the animal...

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