A Curious Case of Anti-D Antibody Titer
RhD alloimmunization remains a threat to 1% of the 10% of RhD-negative women in the United States who are giving birth to RhD-positive fetuses despite routine antenatal and postpartum administration of Rh oD immune globulin (RhIG). This report examines the clinical course of an RhD-negative woman wh...
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| Veröffentlicht in: | Journal of midwifery & women's health 2009-11, Vol.54 (6), p.497-502 |
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| container_title | Journal of midwifery & women's health |
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| creator | Hensley, Jennifer G. Coughlin, Katherine P. Klein, Laura L. |
| description | RhD alloimmunization remains a threat to 1% of the 10% of RhD-negative women in the United States who are giving birth to RhD-positive fetuses despite routine antenatal and postpartum administration of Rh
oD immune globulin (RhIG). This report examines the clinical course of an RhD-negative woman who developed a high anti-D antibody titer during her pregnancy while carrying an RhD-positive female fetus yet had a negative antibody screen at the time she gave birth. Although she delivered a healthy newborn unaffected by hemolytic disease, subsequent pregnancies will be treated as though she is RhD alloimmunized. The discussion below includes possible causes for the abrupt rise in this woman's anti-D antibody titer, a review of the complex Rh system and cellular anamnestic response, and current fetal surveillance for hemolytic disease of the fetus and newborn. |
| doi_str_mv | 10.1016/j.jmwh.2009.08.006 |
| format | Article |
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oD immune globulin (RhIG). This report examines the clinical course of an RhD-negative woman who developed a high anti-D antibody titer during her pregnancy while carrying an RhD-positive female fetus yet had a negative antibody screen at the time she gave birth. Although she delivered a healthy newborn unaffected by hemolytic disease, subsequent pregnancies will be treated as though she is RhD alloimmunized. The discussion below includes possible causes for the abrupt rise in this woman's anti-D antibody titer, a review of the complex Rh system and cellular anamnestic response, and current fetal surveillance for hemolytic disease of the fetus and newborn.</description><identifier>ISSN: 1526-9523</identifier><identifier>EISSN: 1542-2011</identifier><identifier>DOI: 10.1016/j.jmwh.2009.08.006</identifier><identifier>PMID: 19879523</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Inc</publisher><subject>Adult ; Antenatal ; Antibodies ; Childbirth & labor ; Erythroblastosis, Fetal - prevention & control ; Female ; Fetal Monitoring ; Fetuses ; Humans ; Immunoglobulins ; Isoantibodies - blood ; Midwifery ; Newborn babies ; Nursing ; Pregnancy ; Pregnant women ; Prenatal Care - standards ; Rh Isoimmunization - diagnosis ; Rh-Hr Blood-Group System - adverse effects ; Rh-Hr Blood-Group System - blood ; Rho(D) Immune Globulin ; Surveillance ; Women</subject><ispartof>Journal of midwifery & women's health, 2009-11, Vol.54 (6), p.497-502</ispartof><rights>2009 American College of Nurse-Midwives</rights><rights>2009 American College of Nurse Midwives</rights><rights>Copyright Elsevier Science Ltd. Nov/Dec 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5325-926cd0252b6ecfcc01b952ba14d38dee22914525cda6d946c491a63391ed11583</citedby><cites>FETCH-LOGICAL-c5325-926cd0252b6ecfcc01b952ba14d38dee22914525cda6d946c491a63391ed11583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.jmwh.2009.08.006$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.jmwh.2009.08.006$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1417,23930,23931,25140,27924,27925,30999,31000,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19879523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hensley, Jennifer G.</creatorcontrib><creatorcontrib>Coughlin, Katherine P.</creatorcontrib><creatorcontrib>Klein, Laura L.</creatorcontrib><title>A Curious Case of Anti-D Antibody Titer</title><title>Journal of midwifery & women's health</title><addtitle>J Midwifery Womens Health</addtitle><description>RhD alloimmunization remains a threat to 1% of the 10% of RhD-negative women in the United States who are giving birth to RhD-positive fetuses despite routine antenatal and postpartum administration of Rh
oD immune globulin (RhIG). This report examines the clinical course of an RhD-negative woman who developed a high anti-D antibody titer during her pregnancy while carrying an RhD-positive female fetus yet had a negative antibody screen at the time she gave birth. Although she delivered a healthy newborn unaffected by hemolytic disease, subsequent pregnancies will be treated as though she is RhD alloimmunized. The discussion below includes possible causes for the abrupt rise in this woman's anti-D antibody titer, a review of the complex Rh system and cellular anamnestic response, and current fetal surveillance for hemolytic disease of the fetus and newborn.</description><subject>Adult</subject><subject>Antenatal</subject><subject>Antibodies</subject><subject>Childbirth & labor</subject><subject>Erythroblastosis, Fetal - prevention & control</subject><subject>Female</subject><subject>Fetal Monitoring</subject><subject>Fetuses</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Isoantibodies - blood</subject><subject>Midwifery</subject><subject>Newborn babies</subject><subject>Nursing</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Prenatal Care - standards</subject><subject>Rh Isoimmunization - diagnosis</subject><subject>Rh-Hr Blood-Group System - adverse effects</subject><subject>Rh-Hr Blood-Group System - blood</subject><subject>Rho(D) Immune Globulin</subject><subject>Surveillance</subject><subject>Women</subject><issn>1526-9523</issn><issn>1542-2011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkU9v1DAQxS0EoqXwBTigiAM9JXj8L7bEZVmgSykgpKIercSeFQ67m2InlP32OGQFEofCaUbW7z3PzCPkMdAKKKjnXdVtb75UjFJTUV1Rqu6QY5CClYwC3J16pkojGT8iD1LqKIWaGnqfHIHR9fR-TE4XxXKMoR9TsWwSFv26WOyGUL76Vdre74vLMGB8SO6tm03CR4d6Qj6_eX25XJUXH8_eLhcXpZOcydIw5TxlkrUK3do5Cm3-p21AeK49ImMGhGTS-UZ5I5QTBhrFuQH0AFLzE3I6-17H_tuIabDbkBxuNs0O85BWg655zYz8J1lzAaCFYpl8dispaw5U88ny6V9g149xl_e1-aI1iDx9htgMudinFHFtr2PYNnFvgdopF9vZKRc75WKptjmXLHpycB7bLfo_kkMQGdAzcBM2uP8PS3v-_moljJ6mLmdpSAP--C1t4ler8q2kvfpwZj-J83crZrR9mfkXM485x-8Bo00u4M6hDxHdYH0fblvlJ-gBuns</recordid><startdate>200911</startdate><enddate>200911</enddate><creator>Hensley, Jennifer G.</creator><creator>Coughlin, Katherine P.</creator><creator>Klein, Laura L.</creator><general>Elsevier Inc</general><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200911</creationdate><title>A Curious Case of Anti-D Antibody Titer</title><author>Hensley, Jennifer G. ; Coughlin, Katherine P. ; Klein, Laura L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5325-926cd0252b6ecfcc01b952ba14d38dee22914525cda6d946c491a63391ed11583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Antenatal</topic><topic>Antibodies</topic><topic>Childbirth & labor</topic><topic>Erythroblastosis, Fetal - prevention & control</topic><topic>Female</topic><topic>Fetal Monitoring</topic><topic>Fetuses</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Isoantibodies - blood</topic><topic>Midwifery</topic><topic>Newborn babies</topic><topic>Nursing</topic><topic>Pregnancy</topic><topic>Pregnant women</topic><topic>Prenatal Care - standards</topic><topic>Rh Isoimmunization - diagnosis</topic><topic>Rh-Hr Blood-Group System - adverse effects</topic><topic>Rh-Hr Blood-Group System - blood</topic><topic>Rho(D) Immune Globulin</topic><topic>Surveillance</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hensley, Jennifer G.</creatorcontrib><creatorcontrib>Coughlin, Katherine P.</creatorcontrib><creatorcontrib>Klein, Laura L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of midwifery & women's health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hensley, Jennifer G.</au><au>Coughlin, Katherine P.</au><au>Klein, Laura L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Curious Case of Anti-D Antibody Titer</atitle><jtitle>Journal of midwifery & women's health</jtitle><addtitle>J Midwifery Womens Health</addtitle><date>2009-11</date><risdate>2009</risdate><volume>54</volume><issue>6</issue><spage>497</spage><epage>502</epage><pages>497-502</pages><issn>1526-9523</issn><eissn>1542-2011</eissn><abstract>RhD alloimmunization remains a threat to 1% of the 10% of RhD-negative women in the United States who are giving birth to RhD-positive fetuses despite routine antenatal and postpartum administration of Rh
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| ispartof | Journal of midwifery & women's health, 2009-11, Vol.54 (6), p.497-502 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library; Applied Social Sciences Index & Abstracts (ASSIA) |
| subjects | Adult Antenatal Antibodies Childbirth & labor Erythroblastosis, Fetal - prevention & control Female Fetal Monitoring Fetuses Humans Immunoglobulins Isoantibodies - blood Midwifery Newborn babies Nursing Pregnancy Pregnant women Prenatal Care - standards Rh Isoimmunization - diagnosis Rh-Hr Blood-Group System - adverse effects Rh-Hr Blood-Group System - blood Rho(D) Immune Globulin Surveillance Women |
| title | A Curious Case of Anti-D Antibody Titer |
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