Chemotherapy of Cutaneous Herpesvirus Infection of Hairless Mice
A hairless mouse-herpes simplex virus system was used to evaluate the efficacy of a variety of antiviral compounds, inducers of interferon (IF) and exogenous IF. In this model herpes simplex virus produces a local lesion which can be readily examined. Of the DNA virus inhibitors studied, 9-β-D-arabi...
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| Veröffentlicht in: | Journal of investigative dermatology 1973-04, Vol.60 (4), p.203-206 |
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| container_title | Journal of investigative dermatology |
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| creator | Lieberman, Melvin Schafer, Thomas W. Came, Paul E. |
| description | A hairless mouse-herpes simplex virus system was used to evaluate the efficacy of a variety of antiviral compounds, inducers of interferon (IF) and exogenous IF. In this model herpes simplex virus produces a local lesion which can be readily examined. Of the DNA virus inhibitors studied, 9-β-D-arabinofuranosyladenine delayed the onset and reduced the incidence and severity of cutaneous herpetic lesions. Topical application of kethoxal cream (3-ethoxy-2-oxobutyradehyde hydrate) produced a marked suppression of the skin lesions. Cytosine arabinoside was inactive. Of the inducers of IF tested, polyriboinosinic: polyribocytidylic acid and tilorone hydrochloride (2,7-bis[2-(diethylamino)ethoxy]-fluoren-9-one dihydrochloride) did not prevent lesion formation. Exogenous IF was also without effect. |
| doi_str_mv | 10.1111/1523-1747.ep12724476 |
| format | Article |
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In this model herpes simplex virus produces a local lesion which can be readily examined. Of the DNA virus inhibitors studied, 9-β-D-arabinofuranosyladenine delayed the onset and reduced the incidence and severity of cutaneous herpetic lesions. Topical application of kethoxal cream (3-ethoxy-2-oxobutyradehyde hydrate) produced a marked suppression of the skin lesions. Cytosine arabinoside was inactive. Of the inducers of IF tested, polyriboinosinic: polyribocytidylic acid and tilorone hydrochloride (2,7-bis[2-(diethylamino)ethoxy]-fluoren-9-one dihydrochloride) did not prevent lesion formation. 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Exogenous IF was also without effect.</description><subject>Animals</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Bacteriological Techniques</subject><subject>Drug Resistance, Microbial</subject><subject>Hair</subject><subject>Herpes Simplex - drug therapy</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Simplexvirus - drug effects</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gUJP3rYm2XzsXkRZ1BYqXhS8hWx2QiPdD5PdQv-9KS3tzbnMMO87w8yD0C3BMxLjgXCaJkQyOYOOUEkZk-IMjY_tczTGmNKEYvp9ia5C-MGYCMazERqxlOWU8jF6KlZQt_0KvO6209ZOi6HXDbRDmM7BdxA2zsd60VgwvWubnWWunV9DCNN3Z-AaXVi9DnBzyBP09fryWcyT5cfbonheJoZR3icss9ZiKnRaGsHBcm0Jk7gqM5tTw8FIy3KCo4nxCkCQEkoQmPNc21JUaTpB9_u9nW9_Bwi9ql0wsF7vr1UZyWT8Dkcj2xuNb0PwYFXnXa39VhGsduDUjpDaEVIncHHs7rB_KGuojkMHUie90f3g4ahzQaRMadQf9zpECBsHXgXjoDFQOR_Rqap1_x_wB03Hh-s</recordid><startdate>197304</startdate><enddate>197304</enddate><creator>Lieberman, Melvin</creator><creator>Schafer, Thomas W.</creator><creator>Came, Paul E.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197304</creationdate><title>Chemotherapy of Cutaneous Herpesvirus Infection of Hairless Mice</title><author>Lieberman, Melvin ; Schafer, Thomas W. ; Came, Paul E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-48fff026a3bc65ef5af1470db8f92c5ec7f4910fff45dee61bebe60559afb6d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Bacteriological Techniques</topic><topic>Drug Resistance, Microbial</topic><topic>Hair</topic><topic>Herpes Simplex - drug therapy</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Simplexvirus - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lieberman, Melvin</creatorcontrib><creatorcontrib>Schafer, Thomas W.</creatorcontrib><creatorcontrib>Came, Paul E.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lieberman, Melvin</au><au>Schafer, Thomas W.</au><au>Came, Paul E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemotherapy of Cutaneous Herpesvirus Infection of Hairless Mice</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>1973-04</date><risdate>1973</risdate><volume>60</volume><issue>4</issue><spage>203</spage><epage>206</epage><pages>203-206</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><abstract>A hairless mouse-herpes simplex virus system was used to evaluate the efficacy of a variety of antiviral compounds, inducers of interferon (IF) and exogenous IF. 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| identifier | ISSN: 0022-202X |
| ispartof | Journal of investigative dermatology, 1973-04, Vol.60 (4), p.203-206 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Antiviral Agents - therapeutic use Bacteriological Techniques Drug Resistance, Microbial Hair Herpes Simplex - drug therapy Mice Mice, Inbred Strains Simplexvirus - drug effects |
| title | Chemotherapy of Cutaneous Herpesvirus Infection of Hairless Mice |
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