Rabies Neutralizing Antibody: Inadequate Response to Equine Antiserum and Duck-Embryo Vaccine
After exposure to a patient with rabies, 15 hospital staff members received equine antiserum to rabies and duck-embryo rabies vaccine (DEV). Three persons (20%) had a low (
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| Veröffentlicht in: | The Journal of infectious diseases 1973-04, Vol.127 (4), p.433-436 |
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| container_end_page | 436 |
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| container_issue | 4 |
| container_start_page | 433 |
| container_title | The Journal of infectious diseases |
| container_volume | 127 |
| creator | Ellenbogen, Charles Slugg, Peter |
| description | After exposure to a patient with rabies, 15 hospital staff members received equine antiserum to rabies and duck-embryo rabies vaccine (DEV). Three persons (20%) had a low ( |
| doi_str_mv | 10.1093/infdis/127.4.433 |
| format | Article |
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Three persons (20%) had a low (<1:5) or absent serum neutralizing-antibody (SN) response 15 days after treatment began. Sixty-six days after treatment began, six of 13 (46%) had absent or only a low SN response. Forty percent of patients who received both recommended boosters had SN titers at day 66 as low as those who received neither booster. These data indicate that DEV is a poor antigen when combined with horse serum even when prescribed DEV boosters are given. The antibody response of patients given equine antiserum to rabies and DEV should be determined since additional DEV boosters may be required.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 0537-6613</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/127.4.433</identifier><identifier>PMID: 4571703</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Adult ; Animals ; Antibodies ; Antibodies, Viral - analysis ; Antibody Formation ; Antiserum ; Ducks - immunology ; Erythema ; Fluorescent Antibody Technique ; Horses ; Horses - immunology ; Humans ; Immune Sera ; Immunization, Passive ; Immunization, Secondary ; Male ; Mice ; Neutralization Tests ; Neutralizing antibodies ; Rabies ; Rabies - immunology ; Rabies - prevention & control ; Rabies vaccines ; Rabies Vaccines - standards ; Rabies Vaccines - therapeutic use ; Serum sickness ; Skin Tests ; Vaccination ; Vietnam</subject><ispartof>The Journal of infectious diseases, 1973-04, Vol.127 (4), p.433-436</ispartof><rights>Copyright 1973 University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-4a08ab45b67cab16ea6dc7ecb752472ce1e6f581b539ca18419a23fb8f10b2bb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30108715$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30108715$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4571703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ellenbogen, Charles</creatorcontrib><creatorcontrib>Slugg, Peter</creatorcontrib><title>Rabies Neutralizing Antibody: Inadequate Response to Equine Antiserum and Duck-Embryo Vaccine</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>After exposure to a patient with rabies, 15 hospital staff members received equine antiserum to rabies and duck-embryo rabies vaccine (DEV). Three persons (20%) had a low (<1:5) or absent serum neutralizing-antibody (SN) response 15 days after treatment began. Sixty-six days after treatment began, six of 13 (46%) had absent or only a low SN response. Forty percent of patients who received both recommended boosters had SN titers at day 66 as low as those who received neither booster. These data indicate that DEV is a poor antigen when combined with horse serum even when prescribed DEV boosters are given. The antibody response of patients given equine antiserum to rabies and DEV should be determined since additional DEV boosters may be required.</description><subject>Adult</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Viral - analysis</subject><subject>Antibody Formation</subject><subject>Antiserum</subject><subject>Ducks - immunology</subject><subject>Erythema</subject><subject>Fluorescent Antibody Technique</subject><subject>Horses</subject><subject>Horses - immunology</subject><subject>Humans</subject><subject>Immune Sera</subject><subject>Immunization, Passive</subject><subject>Immunization, Secondary</subject><subject>Male</subject><subject>Mice</subject><subject>Neutralization Tests</subject><subject>Neutralizing antibodies</subject><subject>Rabies</subject><subject>Rabies - immunology</subject><subject>Rabies - prevention & control</subject><subject>Rabies vaccines</subject><subject>Rabies Vaccines - standards</subject><subject>Rabies Vaccines - therapeutic use</subject><subject>Serum sickness</subject><subject>Skin Tests</subject><subject>Vaccination</subject><subject>Vietnam</subject><issn>0022-1899</issn><issn>0537-6613</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1LwzAUhoMoft97I-TKu86k-Wq9E506EJX5gQgSkvRUomu7JS04f72dG_PqHHje9xx4EDqiZEBJzk59XRY-ntJUDfiAM7aBdolgKpGSss1-J2ma0CzPd9BejJ-EEM6k2kbbXCiqCNtF72NjPUR8B10bzMT_-PoDn9ett00xP8Oj2hQw60wLeAxx2tQRcNvg4azzNfzlIoSuwqYu8GXnvpJhZcO8wS_GuT5xgLZKM4lwuJr76Plq-HRxk9zeX48uzm8TxwRvE25IZiwXVipnLJVgZOEUOKtEylXqgIIsRUatYLkzNOM0NykrbVZSYlNr2T46Wd6dhmbWQWx15aODycTU0HRRZzRTVEjRB8ky6EITY4BST4OvTJhrSvTCqF4a1b1RzXVvtK8cr253toJiXVgp_OefsW3CGjNCyeJpz5Ml97GF7zU34UtLxZTQN69v-o0zwR7GqX5kv546jLo</recordid><startdate>197304</startdate><enddate>197304</enddate><creator>Ellenbogen, Charles</creator><creator>Slugg, Peter</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197304</creationdate><title>Rabies Neutralizing Antibody: Inadequate Response to Equine Antiserum and Duck-Embryo Vaccine</title><author>Ellenbogen, Charles ; Slugg, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-4a08ab45b67cab16ea6dc7ecb752472ce1e6f581b539ca18419a23fb8f10b2bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Viral - analysis</topic><topic>Antibody Formation</topic><topic>Antiserum</topic><topic>Ducks - immunology</topic><topic>Erythema</topic><topic>Fluorescent Antibody Technique</topic><topic>Horses</topic><topic>Horses - immunology</topic><topic>Humans</topic><topic>Immune Sera</topic><topic>Immunization, Passive</topic><topic>Immunization, Secondary</topic><topic>Male</topic><topic>Mice</topic><topic>Neutralization Tests</topic><topic>Neutralizing antibodies</topic><topic>Rabies</topic><topic>Rabies - immunology</topic><topic>Rabies - prevention & control</topic><topic>Rabies vaccines</topic><topic>Rabies Vaccines - standards</topic><topic>Rabies Vaccines - therapeutic use</topic><topic>Serum sickness</topic><topic>Skin Tests</topic><topic>Vaccination</topic><topic>Vietnam</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ellenbogen, Charles</creatorcontrib><creatorcontrib>Slugg, Peter</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ellenbogen, Charles</au><au>Slugg, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rabies Neutralizing Antibody: Inadequate Response to Equine Antiserum and Duck-Embryo Vaccine</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1973-04</date><risdate>1973</risdate><volume>127</volume><issue>4</issue><spage>433</spage><epage>436</epage><pages>433-436</pages><issn>0022-1899</issn><eissn>0537-6613</eissn><eissn>1537-6613</eissn><abstract>After exposure to a patient with rabies, 15 hospital staff members received equine antiserum to rabies and duck-embryo rabies vaccine (DEV). Three persons (20%) had a low (<1:5) or absent serum neutralizing-antibody (SN) response 15 days after treatment began. Sixty-six days after treatment began, six of 13 (46%) had absent or only a low SN response. Forty percent of patients who received both recommended boosters had SN titers at day 66 as low as those who received neither booster. These data indicate that DEV is a poor antigen when combined with horse serum even when prescribed DEV boosters are given. The antibody response of patients given equine antiserum to rabies and DEV should be determined since additional DEV boosters may be required.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>4571703</pmid><doi>10.1093/infdis/127.4.433</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1973-04, Vol.127 (4), p.433-436 |
| issn | 0022-1899 0537-6613 1537-6613 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adult Animals Antibodies Antibodies, Viral - analysis Antibody Formation Antiserum Ducks - immunology Erythema Fluorescent Antibody Technique Horses Horses - immunology Humans Immune Sera Immunization, Passive Immunization, Secondary Male Mice Neutralization Tests Neutralizing antibodies Rabies Rabies - immunology Rabies - prevention & control Rabies vaccines Rabies Vaccines - standards Rabies Vaccines - therapeutic use Serum sickness Skin Tests Vaccination Vietnam |
| title | Rabies Neutralizing Antibody: Inadequate Response to Equine Antiserum and Duck-Embryo Vaccine |
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