Ventricular dilatation in relation to outcome at 2 years of age in very preterm infants: a prospective Finnish cohort study
Aim The aim of this study was to analyse the relation between ventricular dilatation at term and neurodevelopmental outcome at 2 years corrected age in infants of very low birthweight (VLBW) or very low gestational age (VLGA). Method A total of 225 VLBW or VLGA infants (121 males, 104 female; mean...
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| Veröffentlicht in: | Developmental medicine and child neurology 2011-01, Vol.53 (1), p.48-54 |
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| creator | MAUNU, JONNA LEHTONEN, LIISA LAPINLEIMU, HELENA MATOMÄKI, JAAKKO MUNCK, PETRIINA RIKALAINEN, HELLEVI PARKKOLA, RIITTA HAATAJA, LEENA |
| description | Aim The aim of this study was to analyse the relation between ventricular dilatation at term and neurodevelopmental outcome at 2 years corrected age in infants of very low birthweight (VLBW) or very low gestational age (VLGA).
Method A total of 225 VLBW or VLGA infants (121 males, 104 female; mean birthweight 1133g, SD 333g; mean gestational age 29wks, SD 2wks 5d) born in Turku University Hospital were included. Ventricular–brain ratio and the widths of each lateral ventricular horn were determined using ultrasonography, and the volume of the ventricles was measured by magnetic resonance imaging at term. The 2‐year outcome measures included scores for the Hammersmith Infant Neurological Examination, the presence of cerebral palsy (CP), the Mental Developmental Index (MDI) of the Bayley Scales of Infant Development (2nd edition), and the presence of severe hearing or vision impairments or any neurodevelopmental impairment (NDI).
Results CP was diagnosed in 15 participants (6.7%) and severe hearing deficit in 12 participants (5.3%). No severe vision impairment was found. Mild and severe cognitive delay was found in 24 (10.7%) and 8 (3.6%) of the VLBW or VLGA infants respectively. Isolated ventricular dilatation did not increase the risk for developmental impairments. However, ventricular dilatation with additional brain pathology was significantly associated with CP, MDI score below 70, and NDI. A ventricular–brain ratio above 0.35 was a sensitive measure of developmental impairment.
Interpretation Ventricular dilatation at term increases the risk of poor developmental outcome only when associated with other brain pathology. The ventricular–brain ratio is a useful clinical tool for determining the prognosis in VLBW and VLGA infants. |
| doi_str_mv | 10.1111/j.1469-8749.2010.03785.x |
| format | Article |
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Method A total of 225 VLBW or VLGA infants (121 males, 104 female; mean birthweight 1133g, SD 333g; mean gestational age 29wks, SD 2wks 5d) born in Turku University Hospital were included. Ventricular–brain ratio and the widths of each lateral ventricular horn were determined using ultrasonography, and the volume of the ventricles was measured by magnetic resonance imaging at term. The 2‐year outcome measures included scores for the Hammersmith Infant Neurological Examination, the presence of cerebral palsy (CP), the Mental Developmental Index (MDI) of the Bayley Scales of Infant Development (2nd edition), and the presence of severe hearing or vision impairments or any neurodevelopmental impairment (NDI).
Results CP was diagnosed in 15 participants (6.7%) and severe hearing deficit in 12 participants (5.3%). No severe vision impairment was found. Mild and severe cognitive delay was found in 24 (10.7%) and 8 (3.6%) of the VLBW or VLGA infants respectively. Isolated ventricular dilatation did not increase the risk for developmental impairments. However, ventricular dilatation with additional brain pathology was significantly associated with CP, MDI score below 70, and NDI. A ventricular–brain ratio above 0.35 was a sensitive measure of developmental impairment.
Interpretation Ventricular dilatation at term increases the risk of poor developmental outcome only when associated with other brain pathology. The ventricular–brain ratio is a useful clinical tool for determining the prognosis in VLBW and VLGA infants.</description><identifier>ISSN: 0012-1622</identifier><identifier>EISSN: 1469-8749</identifier><identifier>DOI: 10.1111/j.1469-8749.2010.03785.x</identifier><identifier>PMID: 21039438</identifier><identifier>CODEN: DMCNAW</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Cerebral Ventricles - abnormalities ; Cerebral Ventricles - pathology ; Child, Preschool ; Cohort Studies ; Dilatation, Pathologic - pathology ; Female ; Finland - epidemiology ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Magnetic Resonance Imaging - methods ; Male ; Outcome Assessment (Health Care) - methods ; Pathology ; Premature Birth - epidemiology ; Premature Birth - pathology ; Premature Birth - physiopathology ; Premature Infants ; Severity of Illness Index ; Ultrasonography, Doppler - methods ; Young Children</subject><ispartof>Developmental medicine and child neurology, 2011-01, Vol.53 (1), p.48-54</ispartof><rights>The Authors. Journal compilation © Mac Keith Press 2010</rights><rights>The Authors. Journal compilation © Mac Keith Press 2010.</rights><rights>Copyright Mac Keith Press Jan 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4635-d1e11186104434537dd0c3d8afbdbbe7b22571685506ee0a9b541544f28b0c883</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1469-8749.2010.03785.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1469-8749.2010.03785.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46388,46812</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21039438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MAUNU, JONNA</creatorcontrib><creatorcontrib>LEHTONEN, LIISA</creatorcontrib><creatorcontrib>LAPINLEIMU, HELENA</creatorcontrib><creatorcontrib>MATOMÄKI, JAAKKO</creatorcontrib><creatorcontrib>MUNCK, PETRIINA</creatorcontrib><creatorcontrib>RIKALAINEN, HELLEVI</creatorcontrib><creatorcontrib>PARKKOLA, RIITTA</creatorcontrib><creatorcontrib>HAATAJA, LEENA</creatorcontrib><creatorcontrib>PIPARI Study Group</creatorcontrib><title>Ventricular dilatation in relation to outcome at 2 years of age in very preterm infants: a prospective Finnish cohort study</title><title>Developmental medicine and child neurology</title><addtitle>Dev Med Child Neurol</addtitle><description>Aim The aim of this study was to analyse the relation between ventricular dilatation at term and neurodevelopmental outcome at 2 years corrected age in infants of very low birthweight (VLBW) or very low gestational age (VLGA).
Method A total of 225 VLBW or VLGA infants (121 males, 104 female; mean birthweight 1133g, SD 333g; mean gestational age 29wks, SD 2wks 5d) born in Turku University Hospital were included. Ventricular–brain ratio and the widths of each lateral ventricular horn were determined using ultrasonography, and the volume of the ventricles was measured by magnetic resonance imaging at term. The 2‐year outcome measures included scores for the Hammersmith Infant Neurological Examination, the presence of cerebral palsy (CP), the Mental Developmental Index (MDI) of the Bayley Scales of Infant Development (2nd edition), and the presence of severe hearing or vision impairments or any neurodevelopmental impairment (NDI).
Results CP was diagnosed in 15 participants (6.7%) and severe hearing deficit in 12 participants (5.3%). No severe vision impairment was found. Mild and severe cognitive delay was found in 24 (10.7%) and 8 (3.6%) of the VLBW or VLGA infants respectively. Isolated ventricular dilatation did not increase the risk for developmental impairments. However, ventricular dilatation with additional brain pathology was significantly associated with CP, MDI score below 70, and NDI. A ventricular–brain ratio above 0.35 was a sensitive measure of developmental impairment.
Interpretation Ventricular dilatation at term increases the risk of poor developmental outcome only when associated with other brain pathology. The ventricular–brain ratio is a useful clinical tool for determining the prognosis in VLBW and VLGA infants.</description><subject>Cerebral Ventricles - abnormalities</subject><subject>Cerebral Ventricles - pathology</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Dilatation, Pathologic - pathology</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Outcome Assessment (Health Care) - methods</subject><subject>Pathology</subject><subject>Premature Birth - epidemiology</subject><subject>Premature Birth - pathology</subject><subject>Premature Birth - physiopathology</subject><subject>Premature Infants</subject><subject>Severity of Illness Index</subject><subject>Ultrasonography, Doppler - methods</subject><subject>Young Children</subject><issn>0012-1622</issn><issn>1469-8749</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkctO3DAUhq2Kqgy0r4AsNqwy9TXxsEBCQ6FItGzabi0nOQGPkniwnYEsKiH1TXmSOgyw4GzO7dOvY_8IYUrmNMXX1ZyKfJGpQizmjKQp4YWS84cPaPa22EEzQijLaM7YLtoLYUUI4bkUn9Auo4QvBFcz9PcP9NHbamiNx7VtTTTRuh7bHntot3V02A2xch1gEzF7evw3gvEBuwabG5jQDfgRrz1E8F3qG9PHcIxNGrmwhiraDeBz2_c23OLK3TofcYhDPX5GHxvTBvjykvfR7_Nvv5bfs6vri8vl6VVWiZzLrKaQXq1ySoTgQvKirknFa2Wasi5LKErGZEFzJSXJAYhZlFJQKUTDVEkqpfg-OtrqpoPuBghRdzZU0LamBzcErZK4kIqLRB6-I1du8H06TitGcyIYneQOXqCh7KDWa28740f9-q0JONkC97aF8W1PiZ7s0ys9uaQnl_Rkn362Tz_osx_Ln1PJ_wNhU482</recordid><startdate>201101</startdate><enddate>201101</enddate><creator>MAUNU, JONNA</creator><creator>LEHTONEN, LIISA</creator><creator>LAPINLEIMU, HELENA</creator><creator>MATOMÄKI, JAAKKO</creator><creator>MUNCK, PETRIINA</creator><creator>RIKALAINEN, HELLEVI</creator><creator>PARKKOLA, RIITTA</creator><creator>HAATAJA, LEENA</creator><general>Blackwell Publishing Ltd</general><general>Mac Keith Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0P</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>201101</creationdate><title>Ventricular dilatation in relation to outcome at 2 years of age in very preterm infants: a prospective Finnish cohort study</title><author>MAUNU, JONNA ; LEHTONEN, LIISA ; LAPINLEIMU, HELENA ; MATOMÄKI, JAAKKO ; MUNCK, PETRIINA ; RIKALAINEN, HELLEVI ; PARKKOLA, RIITTA ; HAATAJA, LEENA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4635-d1e11186104434537dd0c3d8afbdbbe7b22571685506ee0a9b541544f28b0c883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Cerebral Ventricles - abnormalities</topic><topic>Cerebral Ventricles - pathology</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Dilatation, Pathologic - pathology</topic><topic>Female</topic><topic>Finland - epidemiology</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Outcome Assessment (Health Care) - methods</topic><topic>Pathology</topic><topic>Premature Birth - epidemiology</topic><topic>Premature Birth - pathology</topic><topic>Premature Birth - physiopathology</topic><topic>Premature Infants</topic><topic>Severity of Illness Index</topic><topic>Ultrasonography, Doppler - methods</topic><topic>Young Children</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAUNU, JONNA</creatorcontrib><creatorcontrib>LEHTONEN, LIISA</creatorcontrib><creatorcontrib>LAPINLEIMU, HELENA</creatorcontrib><creatorcontrib>MATOMÄKI, JAAKKO</creatorcontrib><creatorcontrib>MUNCK, PETRIINA</creatorcontrib><creatorcontrib>RIKALAINEN, HELLEVI</creatorcontrib><creatorcontrib>PARKKOLA, RIITTA</creatorcontrib><creatorcontrib>HAATAJA, LEENA</creatorcontrib><creatorcontrib>PIPARI Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Education Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental medicine and child neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MAUNU, JONNA</au><au>LEHTONEN, LIISA</au><au>LAPINLEIMU, HELENA</au><au>MATOMÄKI, JAAKKO</au><au>MUNCK, PETRIINA</au><au>RIKALAINEN, HELLEVI</au><au>PARKKOLA, RIITTA</au><au>HAATAJA, LEENA</au><aucorp>PIPARI Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ventricular dilatation in relation to outcome at 2 years of age in very preterm infants: a prospective Finnish cohort study</atitle><jtitle>Developmental medicine and child neurology</jtitle><addtitle>Dev Med Child Neurol</addtitle><date>2011-01</date><risdate>2011</risdate><volume>53</volume><issue>1</issue><spage>48</spage><epage>54</epage><pages>48-54</pages><issn>0012-1622</issn><eissn>1469-8749</eissn><coden>DMCNAW</coden><abstract>Aim The aim of this study was to analyse the relation between ventricular dilatation at term and neurodevelopmental outcome at 2 years corrected age in infants of very low birthweight (VLBW) or very low gestational age (VLGA).
Method A total of 225 VLBW or VLGA infants (121 males, 104 female; mean birthweight 1133g, SD 333g; mean gestational age 29wks, SD 2wks 5d) born in Turku University Hospital were included. Ventricular–brain ratio and the widths of each lateral ventricular horn were determined using ultrasonography, and the volume of the ventricles was measured by magnetic resonance imaging at term. The 2‐year outcome measures included scores for the Hammersmith Infant Neurological Examination, the presence of cerebral palsy (CP), the Mental Developmental Index (MDI) of the Bayley Scales of Infant Development (2nd edition), and the presence of severe hearing or vision impairments or any neurodevelopmental impairment (NDI).
Results CP was diagnosed in 15 participants (6.7%) and severe hearing deficit in 12 participants (5.3%). No severe vision impairment was found. Mild and severe cognitive delay was found in 24 (10.7%) and 8 (3.6%) of the VLBW or VLGA infants respectively. Isolated ventricular dilatation did not increase the risk for developmental impairments. However, ventricular dilatation with additional brain pathology was significantly associated with CP, MDI score below 70, and NDI. A ventricular–brain ratio above 0.35 was a sensitive measure of developmental impairment.
Interpretation Ventricular dilatation at term increases the risk of poor developmental outcome only when associated with other brain pathology. The ventricular–brain ratio is a useful clinical tool for determining the prognosis in VLBW and VLGA infants.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21039438</pmid><doi>10.1111/j.1469-8749.2010.03785.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Cerebral Ventricles - abnormalities Cerebral Ventricles - pathology Child, Preschool Cohort Studies Dilatation, Pathologic - pathology Female Finland - epidemiology Gestational Age Humans Infant Infant, Newborn Magnetic Resonance Imaging - methods Male Outcome Assessment (Health Care) - methods Pathology Premature Birth - epidemiology Premature Birth - pathology Premature Birth - physiopathology Premature Infants Severity of Illness Index Ultrasonography, Doppler - methods Young Children |
| title | Ventricular dilatation in relation to outcome at 2 years of age in very preterm infants: a prospective Finnish cohort study |
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