Correlation of Microperimetry with Fundus Autofluorescence and Spectral-Domain Optical Coherence Tomography in Repaired Macular Holes
Purpose To investigate the correlation of microperimetry with fundus autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT), and visual acuity (VA) in order to better characterize visual outcomes after successful macular hole (MH) surgery. Design Cross-sectional case series. M...
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| Veröffentlicht in: | American journal of ophthalmology 2011, Vol.151 (1), p.128-136.e3 |
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| creator | Chung, Hyewon Shin, Chul-Jin Kim, June-Gone Yoon, Young Hee Kim, Hyung Chan |
| description | Purpose To investigate the correlation of microperimetry with fundus autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT), and visual acuity (VA) in order to better characterize visual outcomes after successful macular hole (MH) surgery. Design Cross-sectional case series. Methods Postoperative VA, microperimetry, FAF, and SD-OCT images from 23 eyes of 23 patients who underwent successful MH surgery were obtained. FAF images were examined using the Heidelberg retina angiograph 2, and foveal structure and macular sensitivity were evaluated with SD-OCT and microperimetry. The mean retinal sensitivities within the central 9 degrees (microperimetry, mean), the retinal sensitivity of the foveal center (microperimetry, center), and the difference between the values obtained for the foveal center or mean of study and fellow eyes (microperimetry, centerdiff and microperimetry, meandiff, respectively) were measured with microperimetry. Results Microperimetry (mean) was well correlated with microperimetry (center) in both study and fellow eyes. Poor postoperative VA was correlated with large microperimetry (meandiff). Following successful MH surgery, FAF of all eyes decreased markedly. There was a positive correlation between microperimetry (centerdiff) and degree of FAF of study eyes. However, a decrease in FAF after MH surgery was not correlated well with either degree of defect in the junction between photoreceptor inner and outer segment (IS/OS) or central retinal thickness on SD-OCT. Conclusions The amount of remaining FAF is related to macular sensitivity as measured by microperimetry after successful MH surgery. Function of photoreceptors and retinal pigment epithelium as well as integrity can be estimated by measuring the decrease in FAF after successful MH surgery. Moreover, functional correlation with microperimetry provides both morphologic and functional information on repaired MHs. |
| doi_str_mv | 10.1016/j.ajo.2010.06.040 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_818644970</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002939410004952</els_id><sourcerecordid>818644970</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-7104a9418aff566083444412b112f52427b15889194022afce38befed622c3343</originalsourceid><addsrcrecordid>eNp9kt-L1DAQx4so3nr6B_giARGfuuZX0xZBOFbPE-448M7nkE0nbmrb1KRV9g_w_3bqrh7cg3lJhnxmmPl-J8ueM7pmlKk37dq0Yc0pxlStqaQPshWryjpnVc0eZitKKc9rUcuT7ElKLYaqlOXj7ITTusQstcp-bUKM0JnJh4EER668jWGE6HuY4p789NOOnM9DMydyNk_BdXOIkCwMFogZGnIzgp2i6fL3oTd-INfj5K3pyCbsIP6hbkMfvkYz7vYE_z_DaHyEhlwZO3cmkovQQXqaPXKmS_DseJ9mX84_3G4u8svrj582Z5e5laqY8pJRaWrJKuNcoRSthMTD-JYx7gouebllRYWz15JybpwFUW3BQaM4t0JIcZq9PtQdY_g-Q5p073GYrjMDhDnpilVKStQGyZf3yDbMccDmNKNCiZqWVCHFDhSKllIEp0dUzsQ9QnqxSLcaLdKLRZoqjRZhzotj5XnbQ_Mv468nCLw6AiahlC6awfp0x6GfggqG3NsDB6jYDw9RJ-sXyRsU2E66Cf6_bby7l207PyzefYM9pLtpdeKa6ptll5ZVYviQdcHFb_2Uwuo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1036390706</pqid></control><display><type>article</type><title>Correlation of Microperimetry with Fundus Autofluorescence and Spectral-Domain Optical Coherence Tomography in Repaired Macular Holes</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Chung, Hyewon ; Shin, Chul-Jin ; Kim, June-Gone ; Yoon, Young Hee ; Kim, Hyung Chan</creator><creatorcontrib>Chung, Hyewon ; Shin, Chul-Jin ; Kim, June-Gone ; Yoon, Young Hee ; Kim, Hyung Chan</creatorcontrib><description>Purpose To investigate the correlation of microperimetry with fundus autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT), and visual acuity (VA) in order to better characterize visual outcomes after successful macular hole (MH) surgery. Design Cross-sectional case series. Methods Postoperative VA, microperimetry, FAF, and SD-OCT images from 23 eyes of 23 patients who underwent successful MH surgery were obtained. FAF images were examined using the Heidelberg retina angiograph 2, and foveal structure and macular sensitivity were evaluated with SD-OCT and microperimetry. The mean retinal sensitivities within the central 9 degrees (microperimetry, mean), the retinal sensitivity of the foveal center (microperimetry, center), and the difference between the values obtained for the foveal center or mean of study and fellow eyes (microperimetry, centerdiff and microperimetry, meandiff, respectively) were measured with microperimetry. Results Microperimetry (mean) was well correlated with microperimetry (center) in both study and fellow eyes. Poor postoperative VA was correlated with large microperimetry (meandiff). Following successful MH surgery, FAF of all eyes decreased markedly. There was a positive correlation between microperimetry (centerdiff) and degree of FAF of study eyes. However, a decrease in FAF after MH surgery was not correlated well with either degree of defect in the junction between photoreceptor inner and outer segment (IS/OS) or central retinal thickness on SD-OCT. Conclusions The amount of remaining FAF is related to macular sensitivity as measured by microperimetry after successful MH surgery. Function of photoreceptors and retinal pigment epithelium as well as integrity can be estimated by measuring the decrease in FAF after successful MH surgery. Moreover, functional correlation with microperimetry provides both morphologic and functional information on repaired MHs.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2010.06.040</identifier><identifier>PMID: 20970106</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Basement Membrane - surgery ; Biological and medical sciences ; Cross-Sectional Studies ; Female ; Fluorescein Angiography ; Fluorocarbons - administration & dosage ; Fundus Oculi ; Humans ; Macular degeneration ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Ophthalmology ; Retina ; Retina - physiopathology ; Retinal Perforations - physiopathology ; Retinal Perforations - surgery ; Retinopathies ; Surgery ; Tomography, Optical Coherence ; Visual Acuity - physiology ; Visual Field Tests ; Vitrectomy</subject><ispartof>American journal of ophthalmology, 2011, Vol.151 (1), p.128-136.e3</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-7104a9418aff566083444412b112f52427b15889194022afce38befed622c3343</citedby><cites>FETCH-LOGICAL-c465t-7104a9418aff566083444412b112f52427b15889194022afce38befed622c3343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002939410004952$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23943031$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20970106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Hyewon</creatorcontrib><creatorcontrib>Shin, Chul-Jin</creatorcontrib><creatorcontrib>Kim, June-Gone</creatorcontrib><creatorcontrib>Yoon, Young Hee</creatorcontrib><creatorcontrib>Kim, Hyung Chan</creatorcontrib><title>Correlation of Microperimetry with Fundus Autofluorescence and Spectral-Domain Optical Coherence Tomography in Repaired Macular Holes</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>Purpose To investigate the correlation of microperimetry with fundus autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT), and visual acuity (VA) in order to better characterize visual outcomes after successful macular hole (MH) surgery. Design Cross-sectional case series. Methods Postoperative VA, microperimetry, FAF, and SD-OCT images from 23 eyes of 23 patients who underwent successful MH surgery were obtained. FAF images were examined using the Heidelberg retina angiograph 2, and foveal structure and macular sensitivity were evaluated with SD-OCT and microperimetry. The mean retinal sensitivities within the central 9 degrees (microperimetry, mean), the retinal sensitivity of the foveal center (microperimetry, center), and the difference between the values obtained for the foveal center or mean of study and fellow eyes (microperimetry, centerdiff and microperimetry, meandiff, respectively) were measured with microperimetry. Results Microperimetry (mean) was well correlated with microperimetry (center) in both study and fellow eyes. Poor postoperative VA was correlated with large microperimetry (meandiff). Following successful MH surgery, FAF of all eyes decreased markedly. There was a positive correlation between microperimetry (centerdiff) and degree of FAF of study eyes. However, a decrease in FAF after MH surgery was not correlated well with either degree of defect in the junction between photoreceptor inner and outer segment (IS/OS) or central retinal thickness on SD-OCT. Conclusions The amount of remaining FAF is related to macular sensitivity as measured by microperimetry after successful MH surgery. Function of photoreceptors and retinal pigment epithelium as well as integrity can be estimated by measuring the decrease in FAF after successful MH surgery. Moreover, functional correlation with microperimetry provides both morphologic and functional information on repaired MHs.</description><subject>Aged</subject><subject>Basement Membrane - surgery</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Fluorocarbons - administration & dosage</subject><subject>Fundus Oculi</subject><subject>Humans</subject><subject>Macular degeneration</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Ophthalmology</subject><subject>Retina</subject><subject>Retina - physiopathology</subject><subject>Retinal Perforations - physiopathology</subject><subject>Retinal Perforations - surgery</subject><subject>Retinopathies</subject><subject>Surgery</subject><subject>Tomography, Optical Coherence</subject><subject>Visual Acuity - physiology</subject><subject>Visual Field Tests</subject><subject>Vitrectomy</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt-L1DAQx4so3nr6B_giARGfuuZX0xZBOFbPE-448M7nkE0nbmrb1KRV9g_w_3bqrh7cg3lJhnxmmPl-J8ueM7pmlKk37dq0Yc0pxlStqaQPshWryjpnVc0eZitKKc9rUcuT7ElKLYaqlOXj7ITTusQstcp-bUKM0JnJh4EER668jWGE6HuY4p789NOOnM9DMydyNk_BdXOIkCwMFogZGnIzgp2i6fL3oTd-INfj5K3pyCbsIP6hbkMfvkYz7vYE_z_DaHyEhlwZO3cmkovQQXqaPXKmS_DseJ9mX84_3G4u8svrj582Z5e5laqY8pJRaWrJKuNcoRSthMTD-JYx7gouebllRYWz15JybpwFUW3BQaM4t0JIcZq9PtQdY_g-Q5p073GYrjMDhDnpilVKStQGyZf3yDbMccDmNKNCiZqWVCHFDhSKllIEp0dUzsQ9QnqxSLcaLdKLRZoqjRZhzotj5XnbQ_Mv468nCLw6AiahlC6awfp0x6GfggqG3NsDB6jYDw9RJ-sXyRsU2E66Cf6_bby7l207PyzefYM9pLtpdeKa6ptll5ZVYviQdcHFb_2Uwuo</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Chung, Hyewon</creator><creator>Shin, Chul-Jin</creator><creator>Kim, June-Gone</creator><creator>Yoon, Young Hee</creator><creator>Kim, Hyung Chan</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Correlation of Microperimetry with Fundus Autofluorescence and Spectral-Domain Optical Coherence Tomography in Repaired Macular Holes</title><author>Chung, Hyewon ; Shin, Chul-Jin ; Kim, June-Gone ; Yoon, Young Hee ; Kim, Hyung Chan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-7104a9418aff566083444412b112f52427b15889194022afce38befed622c3343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Basement Membrane - surgery</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Fluorocarbons - administration & dosage</topic><topic>Fundus Oculi</topic><topic>Humans</topic><topic>Macular degeneration</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Ophthalmology</topic><topic>Retina</topic><topic>Retina - physiopathology</topic><topic>Retinal Perforations - physiopathology</topic><topic>Retinal Perforations - surgery</topic><topic>Retinopathies</topic><topic>Surgery</topic><topic>Tomography, Optical Coherence</topic><topic>Visual Acuity - physiology</topic><topic>Visual Field Tests</topic><topic>Vitrectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Hyewon</creatorcontrib><creatorcontrib>Shin, Chul-Jin</creatorcontrib><creatorcontrib>Kim, June-Gone</creatorcontrib><creatorcontrib>Yoon, Young Hee</creatorcontrib><creatorcontrib>Kim, Hyung Chan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Hyewon</au><au>Shin, Chul-Jin</au><au>Kim, June-Gone</au><au>Yoon, Young Hee</au><au>Kim, Hyung Chan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of Microperimetry with Fundus Autofluorescence and Spectral-Domain Optical Coherence Tomography in Repaired Macular Holes</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2011</date><risdate>2011</risdate><volume>151</volume><issue>1</issue><spage>128</spage><epage>136.e3</epage><pages>128-136.e3</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>Purpose To investigate the correlation of microperimetry with fundus autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT), and visual acuity (VA) in order to better characterize visual outcomes after successful macular hole (MH) surgery. Design Cross-sectional case series. Methods Postoperative VA, microperimetry, FAF, and SD-OCT images from 23 eyes of 23 patients who underwent successful MH surgery were obtained. FAF images were examined using the Heidelberg retina angiograph 2, and foveal structure and macular sensitivity were evaluated with SD-OCT and microperimetry. The mean retinal sensitivities within the central 9 degrees (microperimetry, mean), the retinal sensitivity of the foveal center (microperimetry, center), and the difference between the values obtained for the foveal center or mean of study and fellow eyes (microperimetry, centerdiff and microperimetry, meandiff, respectively) were measured with microperimetry. Results Microperimetry (mean) was well correlated with microperimetry (center) in both study and fellow eyes. Poor postoperative VA was correlated with large microperimetry (meandiff). Following successful MH surgery, FAF of all eyes decreased markedly. There was a positive correlation between microperimetry (centerdiff) and degree of FAF of study eyes. However, a decrease in FAF after MH surgery was not correlated well with either degree of defect in the junction between photoreceptor inner and outer segment (IS/OS) or central retinal thickness on SD-OCT. Conclusions The amount of remaining FAF is related to macular sensitivity as measured by microperimetry after successful MH surgery. Function of photoreceptors and retinal pigment epithelium as well as integrity can be estimated by measuring the decrease in FAF after successful MH surgery. Moreover, functional correlation with microperimetry provides both morphologic and functional information on repaired MHs.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20970106</pmid><doi>10.1016/j.ajo.2010.06.040</doi><tpages>9</tpages></addata></record> |
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| subjects | Aged Basement Membrane - surgery Biological and medical sciences Cross-Sectional Studies Female Fluorescein Angiography Fluorocarbons - administration & dosage Fundus Oculi Humans Macular degeneration Male Medical sciences Middle Aged Miscellaneous Ophthalmology Retina Retina - physiopathology Retinal Perforations - physiopathology Retinal Perforations - surgery Retinopathies Surgery Tomography, Optical Coherence Visual Acuity - physiology Visual Field Tests Vitrectomy |
| title | Correlation of Microperimetry with Fundus Autofluorescence and Spectral-Domain Optical Coherence Tomography in Repaired Macular Holes |
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