G-CSF for stem cell therapy in acute myocardial infarction: friend or foe?

Stem cell-based therapy has emerged as a potential therapeutic option for patients with acute myocardial infarction. The ability of granulocyte colony-stimulating factor (G-CSF) to mobilize endogenous stem cells as well as to protect cardiomyocytes at risk via paracrine effects has attracted conside...

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Veröffentlicht in:	Cardiovascular research 2011-01, Vol.89 (1), p.20-30
Hauptverfasser:	SHIM, Winston, MEHTA, Ashish, SZE YUN LIM, GUANGQIN ZHANG, CHONG HEE LIM, CHUA, Terrance, WONG, Philip
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Stem Cells - drug effects Adult Stem Cells - pathology Adult Stem Cells - physiology Animals Biological and medical sciences Cardiology. Vascular system Clinical Trials as Topic Coronary heart disease Female Granulocyte Colony-Stimulating Factor - therapeutic use Heart Humans Janus Kinases - physiology Male Medical sciences Models, Cardiovascular Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - therapy Myocarditis. Cardiomyopathies Myocytes, Cardiac - drug effects Myocytes, Cardiac - pathology Myocytes, Cardiac - physiology Recombinant Proteins Signal Transduction - drug effects STAT3 Transcription Factor - physiology Ventricular Remodeling - drug effects Ventricular Remodeling - physiology
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