Evaluation of Destructive and Reparative Processes in the Liver in Experimental Chronic Granulomatosis of Mixed (Silicotic and Tuberculous) Etiology

Experimental silicosis and silicotuberculosis induced by intravenous injection of silicon dioxide particles are characterized by extensive degenerative and necrotic processes in the liver parenchyma. After 6 months, fibrosis of portal tracts in silicotuberculosis and silicosis was 2.8- and 1.4-fold...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2010-11, Vol.149 (6), p.685-688
Hauptverfasser:	Skurupiy, V. A, Nadeev, A. P, Karpov, M. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cell Biology Chronic Disease Development and progression fibrosis Granuloma - etiology granulomatosis Health aspects Infection Internal Medicine Laboratory Medicine liver Liver - pathology Liver diseases Male Mice Mice, Inbred CBA Pathology regeneration Silicosis - complications Silicosis - pathology silicotuberculosis Tuberculosis Tuberculosis - complications Tuberculosis - pathology
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Beschreibung
Zusammenfassung:	Experimental silicosis and silicotuberculosis induced by intravenous injection of silicon dioxide particles are characterized by extensive degenerative and necrotic processes in the liver parenchyma. After 6 months, fibrosis of portal tracts in silicotuberculosis and silicosis was 2.8- and 1.4-fold more pronounced that in BCG granulomatosis and silicosis, respectively. Depression of cellular and intracellular regeneration processes in the liver parenchyma was also observed.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-010-1024-y