Desensitization for renal transplantation: depletion of donor‐specific anti‐HLA antibodies, preservation of memory antibodies, and clinical risks

Summary Desensitization protocols reduce donor‐specific anti‐HLA antibodies (DSA) and enable renal transplantation in patients with a positive complement‐dependent cytotoxic cross‐match (CDC‐CXM). The effect of this treatment on protective antibody and immunoglobulin levels is unknown. Thirteen pati...

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Veröffentlicht in:	Transplant international 2011-01, Vol.24 (1), p.21-29
Hauptverfasser:	Rogers, Natasha M., Eng, Hooi S., Yu, Raymond, Kireta, Svjetlana, Tsiopelas, Eleni, Bennett, Greg D., Brook, Nicholas R., Gillis, David, Russ, Graeme R., Coates, P. Toby
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged antibodies Antibodies - immunology Antibodies, Bacterial - immunology Antibodies, Monoclonal - therapeutic use desensitization Desensitization, Immunologic - methods Female Health risk assessment HLA Antigens - immunology Humans Immunoglobulin G - analysis Immunoglobulins Immunologic Memory - immunology Immunosuppression - methods Kidney Failure, Chronic - immunology kidney transplant Kidney Transplantation - immunology Male Middle Aged Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - therapeutic use Prednisolone - therapeutic use Preservation Recombinant Fusion Proteins - therapeutic use Streptococcus pneumoniae - immunology Tacrolimus - therapeutic use Tetanus Tetanus - immunology Tissue Donors Transplants & implants
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