The relationship between postprandial bile acid concentration, GLP-1, PYY and ghrelin
Summary Background Gut hormones peptide YY (PYY) and glucagon‐like peptide‐1 (GLP‐1) play an integral role in appetite control and energy homeostasis. Entero‐endocrine L‐cells can be stimulated by nutrients and or bile acids to co‐secrete PYY and GLP‐1. The aim of this study was to determine the re...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2011-01, Vol.74 (1), p.67-72 |
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| creator | Roberts, R. E. Glicksman, C. Alaghband-Zadeh, J. Sherwood, R. A. Akuji, N. le Roux, C. W. |
| description | Summary
Background Gut hormones peptide YY (PYY) and glucagon‐like peptide‐1 (GLP‐1) play an integral role in appetite control and energy homeostasis. Entero‐endocrine L‐cells can be stimulated by nutrients and or bile acids to co‐secrete PYY and GLP‐1. The aim of this study was to determine the response of bile acids, PYY, GLP‐1 and ghrelin after a test meal.
Design Twelve subjects with a BMI of 22·8 (0·52) kg/m2 [mean (SEM)] received a 400 kcal test meal after which blood samples were taken every 30 min from 0 to 180 min. PYY, GLP‐1 and ghrelin were measured by radioimmunoassays. Fractionated bile acids were measured by HPLC‐MSMS.
Results PYY positively correlated with glycochenodeoxycholic acid (GCDCA) (rs = 0·23, P = 0·03) and taurochenodeoxycholic acid (TCDCA) (rs = 0·26, P = 0·02). GLP‐1 positively correlated with GCDCA (rs = 0·22, P = 0·047) and glycodeoxycholic acid (GDCA) (rs = 0·3, P = 0·005). Ghrelin negatively correlated with GDCA (rs = −0·45, P≤ 0·0001), TCDCA (rs = −0·23, P = 0·034) and taurodeoxycholic acid (TDCA) (rs = −0·44, P≤ 0·0001).
Conclusion PYY and GLP‐1 responses correlated with chenodeoxycholic acid (CDCA) counterparts, whereas ghrelin negatively correlated with deoxycholic acid (DCA) counterparts. Specific bile acids may thus differentially affect entero‐endocrine cells. |
| doi_str_mv | 10.1111/j.1365-2265.2010.03886.x |
| format | Article |
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Background Gut hormones peptide YY (PYY) and glucagon‐like peptide‐1 (GLP‐1) play an integral role in appetite control and energy homeostasis. Entero‐endocrine L‐cells can be stimulated by nutrients and or bile acids to co‐secrete PYY and GLP‐1. The aim of this study was to determine the response of bile acids, PYY, GLP‐1 and ghrelin after a test meal.
Design Twelve subjects with a BMI of 22·8 (0·52) kg/m2 [mean (SEM)] received a 400 kcal test meal after which blood samples were taken every 30 min from 0 to 180 min. PYY, GLP‐1 and ghrelin were measured by radioimmunoassays. Fractionated bile acids were measured by HPLC‐MSMS.
Results PYY positively correlated with glycochenodeoxycholic acid (GCDCA) (rs = 0·23, P = 0·03) and taurochenodeoxycholic acid (TCDCA) (rs = 0·26, P = 0·02). GLP‐1 positively correlated with GCDCA (rs = 0·22, P = 0·047) and glycodeoxycholic acid (GDCA) (rs = 0·3, P = 0·005). Ghrelin negatively correlated with GDCA (rs = −0·45, P≤ 0·0001), TCDCA (rs = −0·23, P = 0·034) and taurodeoxycholic acid (TDCA) (rs = −0·44, P≤ 0·0001).
Conclusion PYY and GLP‐1 responses correlated with chenodeoxycholic acid (CDCA) counterparts, whereas ghrelin negatively correlated with deoxycholic acid (DCA) counterparts. Specific bile acids may thus differentially affect entero‐endocrine cells.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2010.03886.x</identifier><identifier>PMID: 21039722</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acids ; Adult ; Bile ; Bile Acids and Salts - blood ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Endocrinopathies ; Fundamental and applied biological sciences. Psychology ; Ghrelin - blood ; Glucagon-Like Peptide 1 - blood ; Glycochenodeoxycholic Acid - blood ; Humans ; Male ; Medical sciences ; Peptide YY - blood ; Postprandial Period ; Tandem Mass Spectrometry ; Vertebrates: endocrinology ; Young Adult</subject><ispartof>Clinical endocrinology (Oxford), 2011-01, Vol.74 (1), p.67-72</ispartof><rights>2010 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2010 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5806-cff1e2df5759dce9eda9560dd64f67e38503e9569be13d911edccbf78e2be1653</citedby><cites>FETCH-LOGICAL-c5806-cff1e2df5759dce9eda9560dd64f67e38503e9569be13d911edccbf78e2be1653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2010.03886.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2010.03886.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23651742$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21039722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roberts, R. E.</creatorcontrib><creatorcontrib>Glicksman, C.</creatorcontrib><creatorcontrib>Alaghband-Zadeh, J.</creatorcontrib><creatorcontrib>Sherwood, R. A.</creatorcontrib><creatorcontrib>Akuji, N.</creatorcontrib><creatorcontrib>le Roux, C. W.</creatorcontrib><title>The relationship between postprandial bile acid concentration, GLP-1, PYY and ghrelin</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Background Gut hormones peptide YY (PYY) and glucagon‐like peptide‐1 (GLP‐1) play an integral role in appetite control and energy homeostasis. Entero‐endocrine L‐cells can be stimulated by nutrients and or bile acids to co‐secrete PYY and GLP‐1. The aim of this study was to determine the response of bile acids, PYY, GLP‐1 and ghrelin after a test meal.
Design Twelve subjects with a BMI of 22·8 (0·52) kg/m2 [mean (SEM)] received a 400 kcal test meal after which blood samples were taken every 30 min from 0 to 180 min. PYY, GLP‐1 and ghrelin were measured by radioimmunoassays. Fractionated bile acids were measured by HPLC‐MSMS.
Results PYY positively correlated with glycochenodeoxycholic acid (GCDCA) (rs = 0·23, P = 0·03) and taurochenodeoxycholic acid (TCDCA) (rs = 0·26, P = 0·02). GLP‐1 positively correlated with GCDCA (rs = 0·22, P = 0·047) and glycodeoxycholic acid (GDCA) (rs = 0·3, P = 0·005). Ghrelin negatively correlated with GDCA (rs = −0·45, P≤ 0·0001), TCDCA (rs = −0·23, P = 0·034) and taurodeoxycholic acid (TDCA) (rs = −0·44, P≤ 0·0001).
Conclusion PYY and GLP‐1 responses correlated with chenodeoxycholic acid (CDCA) counterparts, whereas ghrelin negatively correlated with deoxycholic acid (DCA) counterparts. Specific bile acids may thus differentially affect entero‐endocrine cells.</description><subject>Acids</subject><subject>Adult</subject><subject>Bile</subject><subject>Bile Acids and Salts - blood</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Endocrinopathies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ghrelin - blood</subject><subject>Glucagon-Like Peptide 1 - blood</subject><subject>Glycochenodeoxycholic Acid - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Peptide YY - blood</subject><subject>Postprandial Period</subject><subject>Tandem Mass Spectrometry</subject><subject>Vertebrates: endocrinology</subject><subject>Young Adult</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1v0zAUhi0EYmXjLyBLCHGzdHYcf-SCi1GNglSNaWyadmU59gl1SZNgp1r373HW0klc4Rtbx897ztGDEKZkStM5W00pEzzLc8GnOUlVwpQS0-0LNDl8vEQTwgjJiBDFEXoT44oQwhWRr9FRTgkrZZ5P0O3NEnCAxgy-a-PS97iC4QGgxX0Xhz6Y1nnT4Mo3gI31DtuutdAO4SlwiueLq4ye4qv7e5xQ_HOZevn2BL2qTRPh7f4-RrdfLm5mX7PF9_m32fkis2kRkdm6ppC7mkteOgslOFNyQZwTRS0kMMUJg1QpK6DMlZSCs7aqpYI8VQRnx-jjrm8fut8biINe-2ihaUwL3SZqRZUoCKNFIt__Q666TWjTcpryvORcKEESpXaUDV2MAWrdB7824VFTokfzeqVHwXoUrEfz-sm83qbou_2ATbUGdwj-VZ2AD3vARGuaOqm1Pj5zqS2Vxch92nEPyfnjfy-gZxeX4yvls13exwG2h7wJv7SQTHJ9dznXkn_-sbgj11qyP8SFrKI</recordid><startdate>201101</startdate><enddate>201101</enddate><creator>Roberts, R. E.</creator><creator>Glicksman, C.</creator><creator>Alaghband-Zadeh, J.</creator><creator>Sherwood, R. A.</creator><creator>Akuji, N.</creator><creator>le Roux, C. W.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201101</creationdate><title>The relationship between postprandial bile acid concentration, GLP-1, PYY and ghrelin</title><author>Roberts, R. E. ; Glicksman, C. ; Alaghband-Zadeh, J. ; Sherwood, R. A. ; Akuji, N. ; le Roux, C. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5806-cff1e2df5759dce9eda9560dd64f67e38503e9569be13d911edccbf78e2be1653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acids</topic><topic>Adult</topic><topic>Bile</topic><topic>Bile Acids and Salts - blood</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Endocrinopathies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ghrelin - blood</topic><topic>Glucagon-Like Peptide 1 - blood</topic><topic>Glycochenodeoxycholic Acid - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Peptide YY - blood</topic><topic>Postprandial Period</topic><topic>Tandem Mass Spectrometry</topic><topic>Vertebrates: endocrinology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roberts, R. E.</creatorcontrib><creatorcontrib>Glicksman, C.</creatorcontrib><creatorcontrib>Alaghband-Zadeh, J.</creatorcontrib><creatorcontrib>Sherwood, R. A.</creatorcontrib><creatorcontrib>Akuji, N.</creatorcontrib><creatorcontrib>le Roux, C. W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roberts, R. E.</au><au>Glicksman, C.</au><au>Alaghband-Zadeh, J.</au><au>Sherwood, R. A.</au><au>Akuji, N.</au><au>le Roux, C. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between postprandial bile acid concentration, GLP-1, PYY and ghrelin</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2011-01</date><risdate>2011</risdate><volume>74</volume><issue>1</issue><spage>67</spage><epage>72</epage><pages>67-72</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Background Gut hormones peptide YY (PYY) and glucagon‐like peptide‐1 (GLP‐1) play an integral role in appetite control and energy homeostasis. Entero‐endocrine L‐cells can be stimulated by nutrients and or bile acids to co‐secrete PYY and GLP‐1. The aim of this study was to determine the response of bile acids, PYY, GLP‐1 and ghrelin after a test meal.
Design Twelve subjects with a BMI of 22·8 (0·52) kg/m2 [mean (SEM)] received a 400 kcal test meal after which blood samples were taken every 30 min from 0 to 180 min. PYY, GLP‐1 and ghrelin were measured by radioimmunoassays. Fractionated bile acids were measured by HPLC‐MSMS.
Results PYY positively correlated with glycochenodeoxycholic acid (GCDCA) (rs = 0·23, P = 0·03) and taurochenodeoxycholic acid (TCDCA) (rs = 0·26, P = 0·02). GLP‐1 positively correlated with GCDCA (rs = 0·22, P = 0·047) and glycodeoxycholic acid (GDCA) (rs = 0·3, P = 0·005). Ghrelin negatively correlated with GDCA (rs = −0·45, P≤ 0·0001), TCDCA (rs = −0·23, P = 0·034) and taurodeoxycholic acid (TDCA) (rs = −0·44, P≤ 0·0001).
Conclusion PYY and GLP‐1 responses correlated with chenodeoxycholic acid (CDCA) counterparts, whereas ghrelin negatively correlated with deoxycholic acid (DCA) counterparts. Specific bile acids may thus differentially affect entero‐endocrine cells.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21039722</pmid><doi>10.1111/j.1365-2265.2010.03886.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Adult Bile Bile Acids and Salts - blood Biological and medical sciences Chromatography, High Pressure Liquid Endocrinopathies Fundamental and applied biological sciences. Psychology Ghrelin - blood Glucagon-Like Peptide 1 - blood Glycochenodeoxycholic Acid - blood Humans Male Medical sciences Peptide YY - blood Postprandial Period Tandem Mass Spectrometry Vertebrates: endocrinology Young Adult |
| title | The relationship between postprandial bile acid concentration, GLP-1, PYY and ghrelin |
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