Nitroxyl Antioxidant TPPA-TEMPO Increases the Efficacy of Antitumor Therapy on the Model of Transplantable Mouse Tumor

Nitroxyl antioxidant 4-triphenylphosphonioacetamido-2,2,6,6-tetramethylpiperidine-1-oxyl (TPPA-TEMPO) was synthesized from 4-chloroacetamido-2,2,6,6-tetramethylpiperidine-1-oxyl chloride and triphenylphosphine. Systemic administration of TPPA-TEMPO in the subtoxic dose to mice with lymphosarcoma inh...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2010-12, Vol.150 (1), p.75-78
Hauptverfasser:	Kirilyuk, I. A, Kaledin, V. I, Popova, N. A, Nikolin, V. P, Vasil'eva, E. D, Grigor'ev, I. A, Lushnikova, E. L, Nepomnyashchikh, L. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Active oxygen Animals Antimitotic agents Antineoplastic agents Antineoplastic Agents, Alkylating - therapeutic use Antineoplastic Combined Chemotherapy Protocols Antioxidants Antioxidants - chemistry Antioxidants - therapeutic use Biomedical and Life Sciences Biomedicine Cell Biology Cyclic N-Oxides - chemistry Cyclic N-Oxides - therapeutic use Cyclophosphamide Cyclophosphamide - therapeutic use Internal Medicine Laboratory Medicine LS lymphosarcoma Lymphoma, Non-Hodgkin - drug therapy Male Mice Mice, Inbred CBA Neoplasm Transplantation nitroxyl radicals Pathology therapeutics TPPATEMPO Tumors
Online-Zugang:	Volltext
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