Proliferation of corneal epithelium induced by epidermal growth factor
Epidermal growth factor stimulates the proliferation of corneal epithelium both in organ culture and in vivo. This induction of hyperplasia has been demonstrated histologically with embryonic human and chick corneas in culture. The topical application of the factor to the eyes of rabbits with cornea...
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| Veröffentlicht in: | Experimental eye research 1973-03, Vol.15 (3), p.361-366 |
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| container_end_page | 366 |
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| container_issue | 3 |
| container_start_page | 361 |
| container_title | Experimental eye research |
| container_volume | 15 |
| creator | Savage, C.Richard Cohen, Stanley |
| description | Epidermal growth factor stimulates the proliferation of corneal epithelium both in organ culture and in vivo. This induction of hyperplasia has been demonstrated histologically with embryonic human and chick corneas in culture. The topical application of the factor to the eyes of rabbits with corneal wounds resulted in a marked hyperplasia resembling that observed in culture. However, the effect noted in vivo was transient and the epithelium rapidly regressed to its normal thickness. |
| doi_str_mv | 10.1016/0014-4835(73)90151-6 |
| format | Article |
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This induction of hyperplasia has been demonstrated histologically with embryonic human and chick corneas in culture. The topical application of the factor to the eyes of rabbits with corneal wounds resulted in a marked hyperplasia resembling that observed in culture. 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This induction of hyperplasia has been demonstrated histologically with embryonic human and chick corneas in culture. The topical application of the factor to the eyes of rabbits with corneal wounds resulted in a marked hyperplasia resembling that observed in culture. However, the effect noted in vivo was transient and the epithelium rapidly regressed to its normal thickness.</description><subject>Animals</subject><subject>Chick Embryo</subject><subject>Cornea - drug effects</subject><subject>Corneal Injuries</subject><subject>Epithelium - drug effects</subject><subject>Fetus</subject><subject>Growth Substances - pharmacology</subject><subject>Growth Substances - therapeutic use</subject><subject>Humans</subject><subject>Organ Culture Techniques</subject><subject>Rabbits</subject><subject>Wounds and Injuries - drug therapy</subject><issn>0014-4835</issn><issn>1096-0007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9LwzAUx4Moc07_A4WeRA_VpEma9iLIcCoM9KDnkKQvLtI2M2mV_fe2buzo6cH3x3u8D0LnBN8QTPJbjAlLWUH5laDXJSacpPkBmhJc5inGWByi6T5yjE5i_BxUygSboAnLS84YmaLFa_C1sxBU53ybeJsYH1pQdQJr162gdn2TuLbqDVSJ3oxqBaEZ_I_gf7pVYpXpfDhFR1bVEc52c4beFw9v86d0-fL4PL9fpoZy0aUip0UmQBWlIbhgRGWQ56XlQmcEK1EVWmDQVPEKtLFlRiwzlmusKcWmYiWdocvt3nXwXz3ETjYuGqhr1YLvoyxIwUvC-RBk26AJPsYAVq6Da1TYSILliE-ObOTIRgoq__DJfKhd7Pb3uoFqX9rxGvy7rQ_Dk98OgozGQTvAcQFMJyvv_j_wC9LzfvA</recordid><startdate>197303</startdate><enddate>197303</enddate><creator>Savage, C.Richard</creator><creator>Cohen, Stanley</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197303</creationdate><title>Proliferation of corneal epithelium induced by epidermal growth factor</title><author>Savage, C.Richard ; Cohen, Stanley</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-763827ea89c10841a2e669f57b210a7d8b70eb3a5debcf921f4cf5b0b330cd493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Chick Embryo</topic><topic>Cornea - drug effects</topic><topic>Corneal Injuries</topic><topic>Epithelium - drug effects</topic><topic>Fetus</topic><topic>Growth Substances - pharmacology</topic><topic>Growth Substances - therapeutic use</topic><topic>Humans</topic><topic>Organ Culture Techniques</topic><topic>Rabbits</topic><topic>Wounds and Injuries - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Savage, C.Richard</creatorcontrib><creatorcontrib>Cohen, Stanley</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Savage, C.Richard</au><au>Cohen, Stanley</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proliferation of corneal epithelium induced by epidermal growth factor</atitle><jtitle>Experimental eye research</jtitle><addtitle>Exp Eye Res</addtitle><date>1973-03</date><risdate>1973</risdate><volume>15</volume><issue>3</issue><spage>361</spage><epage>366</epage><pages>361-366</pages><issn>0014-4835</issn><eissn>1096-0007</eissn><abstract>Epidermal growth factor stimulates the proliferation of corneal epithelium both in organ culture and in vivo. This induction of hyperplasia has been demonstrated histologically with embryonic human and chick corneas in culture. The topical application of the factor to the eyes of rabbits with corneal wounds resulted in a marked hyperplasia resembling that observed in culture. However, the effect noted in vivo was transient and the epithelium rapidly regressed to its normal thickness.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>4695441</pmid><doi>10.1016/0014-4835(73)90151-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4835 |
| ispartof | Experimental eye research, 1973-03, Vol.15 (3), p.361-366 |
| issn | 0014-4835 1096-0007 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Chick Embryo Cornea - drug effects Corneal Injuries Epithelium - drug effects Fetus Growth Substances - pharmacology Growth Substances - therapeutic use Humans Organ Culture Techniques Rabbits Wounds and Injuries - drug therapy |
| title | Proliferation of corneal epithelium induced by epidermal growth factor |
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