Oncolytic Effect of Bovine Enterovirus on Mouse and Human Tumours

WE have previously reported the oncolytic effect of bovine enterovirus 1 on Ehrlich carcinoma and sarcoma 1 in both the solid and ascites form in mice. The basis of the oncolytic specificity was associated with the adsorption spectrum of the virus1,2. We have now extended this work to a larger spectrum of transplantable tumours in inbred strains of mice, and to initial experiments on the cytopathic effect of BE virus on a number of cell lines and primary cells of human origin. These results demonstrate that the oncolytic effect of BE virus, and perhaps other enteroviruses, may be more than a "laboratory curiosity"3 and may be of use against certain types of neoplasia.