Effect of Calcium on Force-Velocity-Length Relations of Heart Muscle of the Cat
The influence of calcium concentration in the bathing solution on the force-velocity relations of the isolated, electrically excited cat papillary muscle was examined. Shortening velocity was directly measured at minimum loads by unloading or load clamping the muscle from the preload (at the length,...
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| Veröffentlicht in: | Circulation research 1973-03, Vol.32 (3), p.385-392 |
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| creator | BRUTSAERT, DIRK L CLAES, VICTOR A GOETHALS, MARK A |
| description | The influence of calcium concentration in the bathing solution on the force-velocity relations of the isolated, electrically excited cat papillary muscle was examined. Shortening velocity was directly measured at minimum loads by unloading or load clamping the muscle from the preload (at the length, Lmax, where maximum active tensio was developed) to 0 (zero-load clamp), 2, 5, 10, and 15% of the total tension, P0. All measurements were made in the physiological length range between Lmax and 12.5% below Lmax. Increasing the calcium concentration augmented the measured maximum unloaded shortening velocity and shifted the normalized force-velocity relation when force was expressed as a fraction of P0. These observations suggest that the activating calcium has an action more complex than the binding to troponin alone. |
| doi_str_mv | 10.1161/01.RES.32.3.385 |
| format | Article |
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Shortening velocity was directly measured at minimum loads by unloading or load clamping the muscle from the preload (at the length, Lmax, where maximum active tensio was developed) to 0 (zero-load clamp), 2, 5, 10, and 15% of the total tension, P0. All measurements were made in the physiological length range between Lmax and 12.5% below Lmax. Increasing the calcium concentration augmented the measured maximum unloaded shortening velocity and shifted the normalized force-velocity relation when force was expressed as a fraction of P0. These observations suggest that the activating calcium has an action more complex than the binding to troponin alone.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.RES.32.3.385</identifier><identifier>PMID: 4691344</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Animals ; Calcium - pharmacology ; Cats ; Electric Stimulation ; Heart - drug effects ; Heart - physiology ; Muscle Contraction ; Papillary Muscles - drug effects ; Papillary Muscles - physiology ; Stimulation, Chemical ; Stress, Mechanical</subject><ispartof>Circulation research, 1973-03, Vol.32 (3), p.385-392</ispartof><rights>1973 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3731-df39c31cdc65d88de0b5ca67a2c0e69acad5f1f1c5093c3354985ea5370600e93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4691344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BRUTSAERT, DIRK L</creatorcontrib><creatorcontrib>CLAES, VICTOR A</creatorcontrib><creatorcontrib>GOETHALS, MARK A</creatorcontrib><title>Effect of Calcium on Force-Velocity-Length Relations of Heart Muscle of the Cat</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>The influence of calcium concentration in the bathing solution on the force-velocity relations of the isolated, electrically excited cat papillary muscle was examined. Shortening velocity was directly measured at minimum loads by unloading or load clamping the muscle from the preload (at the length, Lmax, where maximum active tensio was developed) to 0 (zero-load clamp), 2, 5, 10, and 15% of the total tension, P0. All measurements were made in the physiological length range between Lmax and 12.5% below Lmax. Increasing the calcium concentration augmented the measured maximum unloaded shortening velocity and shifted the normalized force-velocity relation when force was expressed as a fraction of P0. These observations suggest that the activating calcium has an action more complex than the binding to troponin alone.</description><subject>Animals</subject><subject>Calcium - pharmacology</subject><subject>Cats</subject><subject>Electric Stimulation</subject><subject>Heart - drug effects</subject><subject>Heart - physiology</subject><subject>Muscle Contraction</subject><subject>Papillary Muscles - drug effects</subject><subject>Papillary Muscles - physiology</subject><subject>Stimulation, Chemical</subject><subject>Stress, Mechanical</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1v2zAMhoVhQ5d1O-80wKfd5JKmZFvHIUjXASkKdB9XQZXpxZsSdZKMov9-DhL0QJAEH76HR4iPCDVii1eA9f3me01NTTX1-pVYoW6UVLrD12IFAEZ2RPBWvMv5DwAqasyFuFCtQVJqJe4248i-VHGs1i74ad5X8VBdx-RZ_uIQ_VSe5ZYPv8uuuufgyhQP-UjfsEulup2zD3zcy46XhPJevBldyPzh3C_Fz-vNj_WN3N59_bb-spWeOkI5jGQ8oR98q4e-HxgetHdt5xoP3Brn3aBHHNFrMOSJtDK9ZqepgxaADV2Kz6fcxxT_zZyL3U_ZcwjuwHHOtsdeNV3fLeDVCfQp5px4tI9p2rv0bBHsUaEFtItCS40luyhcPj6do-eHPQ8v_NnZclen-1MMhVP-G-YnTnbHLpSdXZQDATYSTUfLBCCXQqT_TgN6nQ</recordid><startdate>197303</startdate><enddate>197303</enddate><creator>BRUTSAERT, DIRK L</creator><creator>CLAES, VICTOR A</creator><creator>GOETHALS, MARK A</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197303</creationdate><title>Effect of Calcium on Force-Velocity-Length Relations of Heart Muscle of the Cat</title><author>BRUTSAERT, DIRK L ; CLAES, VICTOR A ; GOETHALS, MARK A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3731-df39c31cdc65d88de0b5ca67a2c0e69acad5f1f1c5093c3354985ea5370600e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Calcium - pharmacology</topic><topic>Cats</topic><topic>Electric Stimulation</topic><topic>Heart - drug effects</topic><topic>Heart - physiology</topic><topic>Muscle Contraction</topic><topic>Papillary Muscles - drug effects</topic><topic>Papillary Muscles - physiology</topic><topic>Stimulation, Chemical</topic><topic>Stress, Mechanical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BRUTSAERT, DIRK L</creatorcontrib><creatorcontrib>CLAES, VICTOR A</creatorcontrib><creatorcontrib>GOETHALS, MARK A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BRUTSAERT, DIRK L</au><au>CLAES, VICTOR A</au><au>GOETHALS, MARK A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Calcium on Force-Velocity-Length Relations of Heart Muscle of the Cat</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1973-03</date><risdate>1973</risdate><volume>32</volume><issue>3</issue><spage>385</spage><epage>392</epage><pages>385-392</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><abstract>The influence of calcium concentration in the bathing solution on the force-velocity relations of the isolated, electrically excited cat papillary muscle was examined. Shortening velocity was directly measured at minimum loads by unloading or load clamping the muscle from the preload (at the length, Lmax, where maximum active tensio was developed) to 0 (zero-load clamp), 2, 5, 10, and 15% of the total tension, P0. All measurements were made in the physiological length range between Lmax and 12.5% below Lmax. Increasing the calcium concentration augmented the measured maximum unloaded shortening velocity and shifted the normalized force-velocity relation when force was expressed as a fraction of P0. These observations suggest that the activating calcium has an action more complex than the binding to troponin alone.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>4691344</pmid><doi>10.1161/01.RES.32.3.385</doi><tpages>8</tpages></addata></record> |
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| ispartof | Circulation research, 1973-03, Vol.32 (3), p.385-392 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_81842787 |
| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Animals Calcium - pharmacology Cats Electric Stimulation Heart - drug effects Heart - physiology Muscle Contraction Papillary Muscles - drug effects Papillary Muscles - physiology Stimulation, Chemical Stress, Mechanical |
| title | Effect of Calcium on Force-Velocity-Length Relations of Heart Muscle of the Cat |
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