Cardiac allograft pathology in rhesus monkeys
Orthotopic, allogeneic heart transplantations were performed in 26 randomly selected rhesus monkeys to study the effect of immunosuppressive treatment on survival and cardiac morphology. The histological picture of the acute and chronically rejected hearts was similar to that described for acute and...
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| Veröffentlicht in: | American journal of physical anthropology 1973-03, Vol.38 (2), p.431-433 |
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| container_title | American journal of physical anthropology |
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| creator | Hollander, C. F. |
| description | Orthotopic, allogeneic heart transplantations were performed in 26 randomly selected rhesus monkeys to study the effect of immunosuppressive treatment on survival and cardiac morphology. The histological picture of the acute and chronically rejected hearts was similar to that described for acute and chronic cardiac allograft rejection in man. As seems to be the case in man, an obliterative arteritis of the coronary arteries appears to be the limiting factor in cardiac allograft survival in the rhesus monkey. Immunosuppressive treatment with either Imuran and ALS or Imuran, ALS, and Prednisone could not prevent the occurrence of obliterative arteritis of the coronary arteries. Contrary to the observation in man, no atherosclerotic changes were found in the affected parts of the coronary arteries or in the non‐diseased parts. |
| doi_str_mv | 10.1002/ajpa.1330380244 |
| format | Article |
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F.</creator><creatorcontrib>Hollander, C. F.</creatorcontrib><description>Orthotopic, allogeneic heart transplantations were performed in 26 randomly selected rhesus monkeys to study the effect of immunosuppressive treatment on survival and cardiac morphology. The histological picture of the acute and chronically rejected hearts was similar to that described for acute and chronic cardiac allograft rejection in man. As seems to be the case in man, an obliterative arteritis of the coronary arteries appears to be the limiting factor in cardiac allograft survival in the rhesus monkey. Immunosuppressive treatment with either Imuran and ALS or Imuran, ALS, and Prednisone could not prevent the occurrence of obliterative arteritis of the coronary arteries. Contrary to the observation in man, no atherosclerotic changes were found in the affected parts of the coronary arteries or in the non‐diseased parts.</description><identifier>ISSN: 0002-9483</identifier><identifier>EISSN: 1096-8644</identifier><identifier>DOI: 10.1002/ajpa.1330380244</identifier><identifier>PMID: 4632089</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Antilymphocyte Serum ; Arteriosclerosis - pathology ; Azathioprine - therapeutic use ; Coronary Disease - pathology ; Coronary Vessels - pathology ; Graft Rejection - drug effects ; Haplorhini ; Heart Transplantation ; Immunosuppressive Agents - therapeutic use ; Macaca ; Macrophages - immunology ; Prednisone - therapeutic use ; Transplantation, Homologous</subject><ispartof>American journal of physical anthropology, 1973-03, Vol.38 (2), p.431-433</ispartof><rights>Copyright © 1973 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3824-6d09988353f650d74232a5ae5d8d11667b8865e2e5cdc95f00bfa509184dca4a3</citedby><cites>FETCH-LOGICAL-c3824-6d09988353f650d74232a5ae5d8d11667b8865e2e5cdc95f00bfa509184dca4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajpa.1330380244$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajpa.1330380244$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4632089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hollander, C. F.</creatorcontrib><title>Cardiac allograft pathology in rhesus monkeys</title><title>American journal of physical anthropology</title><addtitle>Am. J. Phys. Anthropol</addtitle><description>Orthotopic, allogeneic heart transplantations were performed in 26 randomly selected rhesus monkeys to study the effect of immunosuppressive treatment on survival and cardiac morphology. The histological picture of the acute and chronically rejected hearts was similar to that described for acute and chronic cardiac allograft rejection in man. As seems to be the case in man, an obliterative arteritis of the coronary arteries appears to be the limiting factor in cardiac allograft survival in the rhesus monkey. Immunosuppressive treatment with either Imuran and ALS or Imuran, ALS, and Prednisone could not prevent the occurrence of obliterative arteritis of the coronary arteries. Contrary to the observation in man, no atherosclerotic changes were found in the affected parts of the coronary arteries or in the non‐diseased parts.</description><subject>Animals</subject><subject>Antilymphocyte Serum</subject><subject>Arteriosclerosis - pathology</subject><subject>Azathioprine - therapeutic use</subject><subject>Coronary Disease - pathology</subject><subject>Coronary Vessels - pathology</subject><subject>Graft Rejection - drug effects</subject><subject>Haplorhini</subject><subject>Heart Transplantation</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Macaca</subject><subject>Macrophages - immunology</subject><subject>Prednisone - therapeutic use</subject><subject>Transplantation, Homologous</subject><issn>0002-9483</issn><issn>1096-8644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PwkAYhDdGg4iePZn05K2w393GExJBgSAmGo-bpd1KoaV1t43237ukBOPJ5E3eTOaZOQwA1wj2EYR4oDal6iNCIBEQU3oCugiG3Bec0lPQhQ7xQyrIObiwduMkd9cBHcoJhiLsAn-kTJyqyFNZVnwYlVReqap14UTjpTvPrLWtrZcXu61u7CU4S1Rm9dXh98Db-OF19OjPnydPo-Hcj4jA1OcxDEMhCCMJZzAOKCZYMaVZLGKEOA9WQnCmsWZRHIUsgXCVKAZDJGgcKapID9y2vaUpPmttK5mnNtJZpna6qK0UjoQ4gA4ctGBkCmuNTmRp0lyZRiIo9wPJ_UDydyCXuDlU16tcx0f-sIjz71r_K81081-dHE6Xwz_tfptObaW_j2lltpIHJGDyfTGRLws2ns2mS3lPfgBTnoBh</recordid><startdate>197303</startdate><enddate>197303</enddate><creator>Hollander, C. F.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197303</creationdate><title>Cardiac allograft pathology in rhesus monkeys</title><author>Hollander, C. F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3824-6d09988353f650d74232a5ae5d8d11667b8865e2e5cdc95f00bfa509184dca4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Antilymphocyte Serum</topic><topic>Arteriosclerosis - pathology</topic><topic>Azathioprine - therapeutic use</topic><topic>Coronary Disease - pathology</topic><topic>Coronary Vessels - pathology</topic><topic>Graft Rejection - drug effects</topic><topic>Haplorhini</topic><topic>Heart Transplantation</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Macaca</topic><topic>Macrophages - immunology</topic><topic>Prednisone - therapeutic use</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hollander, C. F.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physical anthropology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hollander, C. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac allograft pathology in rhesus monkeys</atitle><jtitle>American journal of physical anthropology</jtitle><addtitle>Am. J. Phys. Anthropol</addtitle><date>1973-03</date><risdate>1973</risdate><volume>38</volume><issue>2</issue><spage>431</spage><epage>433</epage><pages>431-433</pages><issn>0002-9483</issn><eissn>1096-8644</eissn><abstract>Orthotopic, allogeneic heart transplantations were performed in 26 randomly selected rhesus monkeys to study the effect of immunosuppressive treatment on survival and cardiac morphology. The histological picture of the acute and chronically rejected hearts was similar to that described for acute and chronic cardiac allograft rejection in man. As seems to be the case in man, an obliterative arteritis of the coronary arteries appears to be the limiting factor in cardiac allograft survival in the rhesus monkey. Immunosuppressive treatment with either Imuran and ALS or Imuran, ALS, and Prednisone could not prevent the occurrence of obliterative arteritis of the coronary arteries. Contrary to the observation in man, no atherosclerotic changes were found in the affected parts of the coronary arteries or in the non‐diseased parts.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>4632089</pmid><doi>10.1002/ajpa.1330380244</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9483 |
| ispartof | American journal of physical anthropology, 1973-03, Vol.38 (2), p.431-433 |
| issn | 0002-9483 1096-8644 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Antilymphocyte Serum Arteriosclerosis - pathology Azathioprine - therapeutic use Coronary Disease - pathology Coronary Vessels - pathology Graft Rejection - drug effects Haplorhini Heart Transplantation Immunosuppressive Agents - therapeutic use Macaca Macrophages - immunology Prednisone - therapeutic use Transplantation, Homologous |
| title | Cardiac allograft pathology in rhesus monkeys |
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