TLR7 regulates dendritic cell-dependent B-cell responses through BlyS in immune thrombocytopenic purpura

Objectives: Immune thrombocytopenic purpura (ITP) is an autoimmune disorder in which anti‐platelet antibodies induce platelet destruction owing to an imbalanced immune response. Several studies have established that B cells play an important role in the production of anti‐platelet antibodies and th...

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Veröffentlicht in:	European journal of haematology 2011-01, Vol.86 (1), p.67-74
Hauptverfasser:	Yu, Huiming, Liu, Yunfang, Han, Junqing, Yang, Zhe, Sheng, Wei, Dai, Honghai, Wang, Yingjie, Xia, Tingyi, Hou, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen-Presenting Cells - pathology Autoantibodies - blood B cells B-Cell Activating Factor - blood B-Cell Activating Factor - genetics B-Cell Activating Factor - immunology B-lymphocyte stimulator B-Lymphocytes - immunology B-Lymphocytes - pathology Case-Control Studies Cells, Cultured dendritic cells Dendritic Cells - immunology Glycoproteins - immunology immune thrombocytopenic purpura Monocytes - pathology Purpura, Thrombocytopenic, Idiopathic - etiology Purpura, Thrombocytopenic, Idiopathic - immunology RNA, Messenger - analysis toll-like receptor 7 Toll-Like Receptor 7 - genetics Toll-Like Receptor 7 - immunology
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