“occlusis” model of cell fate restriction

A simple model, termed “occlusis”, is presented here to account for both cell fate restriction during somatic development and reestablishment of pluripotency during reproduction. The model makes three assertions: (1) A gene's transcriptional potential can assume one of two states: the “competen...

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Veröffentlicht in:	BioEssays 2011, Vol.33 (1), p.13-20
1. Verfasser:	Lahn, Bruce T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - genetics cell fate restriction Cell Growth Processes cells Chromatin - genetics deocclusion Gene Expression Regulation, Developmental - physiology Gene Silencing genes Genome germ cells Humans Models, Biological occludome occlusion occlusis Pluripotent Stem Cells - physiology Reproduction Trans-Activators - genetics transactivators transcription (genetics) Transcription, Genetic - physiology Transcriptional Activation
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