“occlusis” model of cell fate restriction
A simple model, termed “occlusis”, is presented here to account for both cell fate restriction during somatic development and reestablishment of pluripotency during reproduction. The model makes three assertions: (1) A gene's transcriptional potential can assume one of two states: the “competen...
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| Veröffentlicht in: | BioEssays 2011, Vol.33 (1), p.13-20 |
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| creator | Lahn, Bruce T |
| description | A simple model, termed “occlusis”, is presented here to account for both cell fate restriction during somatic development and reestablishment of pluripotency during reproduction. The model makes three assertions: (1) A gene's transcriptional potential can assume one of two states: the “competent” state, wherein the gene is responsive to, and can be activated by, trans‐acting factors in the cellular milieu, and the “occluded” state, wherein the gene is blocked by cis‐acting, chromatin‐based mechanisms from responding to trans‐acting factors such that it remains silent irrespective of whether transcriptional activators are present in the milieu. (2) As differentiation proceeds in somatic lineages, lineage‐inappropriate genes shift progressively and irreversibly from competent to occluded state, thereby leading to the restriction of cell fate. (3) During reproduction, global deocclusion takes place in the germline and/or early zygotic cells to reset the genome to the competent state in order to facilitate a new round of organismal development. |
| doi_str_mv | 10.1002/bies.201000090 |
| format | Article |
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(3) During reproduction, global deocclusion takes place in the germline and/or early zygotic cells to reset the genome to the competent state in order to facilitate a new round of organismal development.</description><subject>Animals</subject><subject>Cell Differentiation - genetics</subject><subject>cell fate restriction</subject><subject>Cell Growth Processes</subject><subject>cells</subject><subject>Chromatin - genetics</subject><subject>deocclusion</subject><subject>Gene Expression Regulation, Developmental - physiology</subject><subject>Gene Silencing</subject><subject>genes</subject><subject>Genome</subject><subject>germ cells</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>occludome</subject><subject>occlusion</subject><subject>occlusis</subject><subject>Pluripotent Stem Cells - physiology</subject><subject>Reproduction</subject><subject>Trans-Activators - genetics</subject><subject>transactivators</subject><subject>transcription (genetics)</subject><subject>Transcription, Genetic - 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genetics</topic><topic>cell fate restriction</topic><topic>Cell Growth Processes</topic><topic>cells</topic><topic>Chromatin - genetics</topic><topic>deocclusion</topic><topic>Gene Expression Regulation, Developmental - physiology</topic><topic>Gene Silencing</topic><topic>genes</topic><topic>Genome</topic><topic>germ cells</topic><topic>Humans</topic><topic>Models, Biological</topic><topic>occludome</topic><topic>occlusion</topic><topic>occlusis</topic><topic>Pluripotent Stem Cells - physiology</topic><topic>Reproduction</topic><topic>Trans-Activators - genetics</topic><topic>transactivators</topic><topic>transcription (genetics)</topic><topic>Transcription, Genetic - physiology</topic><topic>Transcriptional Activation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lahn, Bruce T</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>BioEssays</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lahn, Bruce T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>“occlusis” model of cell fate restriction</atitle><jtitle>BioEssays</jtitle><addtitle>Bioessays</addtitle><date>2011</date><risdate>2011</risdate><volume>33</volume><issue>1</issue><spage>13</spage><epage>20</epage><pages>13-20</pages><issn>0265-9247</issn><eissn>1521-1878</eissn><coden>BIOEEJ</coden><abstract>A simple model, termed “occlusis”, is presented here to account for both cell fate restriction during somatic development and reestablishment of pluripotency during reproduction. 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(3) During reproduction, global deocclusion takes place in the germline and/or early zygotic cells to reset the genome to the competent state in order to facilitate a new round of organismal development.</abstract><cop>Weinheim</cop><pub>Wiley‐VCH Verlag</pub><pmid>20954221</pmid><doi>10.1002/bies.201000090</doi><tpages>8</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Animals Cell Differentiation - genetics cell fate restriction Cell Growth Processes cells Chromatin - genetics deocclusion Gene Expression Regulation, Developmental - physiology Gene Silencing genes Genome germ cells Humans Models, Biological occludome occlusion occlusis Pluripotent Stem Cells - physiology Reproduction Trans-Activators - genetics transactivators transcription (genetics) Transcription, Genetic - physiology Transcriptional Activation |
| title | “occlusis” model of cell fate restriction |
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