Amniotic fluid phospholipids and fetal maturity

The phospholipid concentration in duplicate amniotic fluid specimens from 120 patients between the fourteenth and forty-second weeks of gestation was determined. A significant rise in both lecithin concentration and the lecithin/sphingomyelin (L/S) ratio began at 34 weeks and plateaued at 38 weeks....

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Veröffentlicht in:American journal of obstetrics and gynecology 1973-02, Vol.115 (3), p.298-306
Hauptverfasser: Harding, P., Possmayer, F., Milne, K., Jaco, N.T., Walters, J.H.
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Sprache:eng
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Zusammenfassung:The phospholipid concentration in duplicate amniotic fluid specimens from 120 patients between the fourteenth and forty-second weeks of gestation was determined. A significant rise in both lecithin concentration and the lecithin/sphingomyelin (L/S) ratio began at 34 weeks and plateaued at 38 weeks. The maturity of infants who were delivered within 48 hours of amniotic fluid determinations was assessed with the Dubowitz scoring system, which concentrates on nervous system parameters. A stronger correlation was evident between the L/S ratio-maturity score than between the L/S ratio-birth weight. Of 20 viable infants (> 20 weeks) who demonstrated an amniotic fluid L/S ratio less than 2 within 48 hours of birth, 6 developed the respiratory distress syndrome (RDS) from which 2 died. No infant associated with a ratio of greater than 2 within 2 days of birth developed RDS. The addition of small graduated quantities of blood to amniotic fluid was shown to alter the phospholipid concentration and the L/S ratio.
ISSN:0002-9378
1097-6868
DOI:10.1016/0002-9378(73)90582-6