Malnutrition and malabsorption in crohn's disease with reference to the effect of surgery
Sixty‐three patients with Crohn's disease showed a high incidence of nutritional deficiencies as judged by laboratory tests. Malabsorption of fat (33 per cent) and vitamin B12 (60 per cent) was not sufficiently severe to account for the malnutrition. Malnutrition was especially severe in unoper...
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| Veröffentlicht in: | British journal of surgery 1973-02, Vol.60 (2), p.134-140 |
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| container_title | British journal of surgery |
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| creator | Dyer, N. H. Dawson, A. M. |
| description | Sixty‐three patients with Crohn's disease showed a high incidence of nutritional deficiencies as judged by laboratory tests. Malabsorption of fat (33 per cent) and vitamin B12 (60 per cent) was not sufficiently severe to account for the malnutrition. Malnutrition was especially severe in unoperated patients with active disease, whereas malabsorption was prominent in patients with recurrent disease after resection although they had less active disease and less severe nutritional deficits. Surgery should not be withheld from a malnourished patient for fear of inducing further malnutrition; excision of toxic inflammatory disease will not only improve the immediate outlook but will also reduce the severity of further recurrences. Xylose‐excretion tests give a spurious impression of malabsorption in Crohn's disease, possibly as a result of occult renal impairment, and should be abandoned. |
| doi_str_mv | 10.1002/bjs.1800600211 |
| format | Article |
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H. ; Dawson, A. M.</creator><creatorcontrib>Dyer, N. H. ; Dawson, A. M.</creatorcontrib><description>Sixty‐three patients with Crohn's disease showed a high incidence of nutritional deficiencies as judged by laboratory tests. Malabsorption of fat (33 per cent) and vitamin B12 (60 per cent) was not sufficiently severe to account for the malnutrition. Malnutrition was especially severe in unoperated patients with active disease, whereas malabsorption was prominent in patients with recurrent disease after resection although they had less active disease and less severe nutritional deficits. Surgery should not be withheld from a malnourished patient for fear of inducing further malnutrition; excision of toxic inflammatory disease will not only improve the immediate outlook but will also reduce the severity of further recurrences. Xylose‐excretion tests give a spurious impression of malabsorption in Crohn's disease, possibly as a result of occult renal impairment, and should be abandoned.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800600211</identifier><identifier>PMID: 4685936</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Crohn Disease - blood ; Crohn Disease - complications ; Crohn Disease - surgery ; Fats - analysis ; Feces - analysis ; Female ; Folic Acid - blood ; Hemoglobins - analysis ; Humans ; Ileum - surgery ; Intestinal Absorption ; Malabsorption Syndromes - etiology ; Male ; Nutrition Disorders - etiology ; Serum Albumin - analysis ; Vitamin B 12 - blood ; Xylose - metabolism</subject><ispartof>British journal of surgery, 1973-02, Vol.60 (2), p.134-140</ispartof><rights>Copyright © 1973 British Journal of Surgery Society Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3391-860cdb0e5c9c502b553e9bb03b3ecd460dbbb6d04e98d260cd50f605a353f3173</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.1800600211$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.1800600211$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4685936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dyer, N. H.</creatorcontrib><creatorcontrib>Dawson, A. M.</creatorcontrib><title>Malnutrition and malabsorption in crohn's disease with reference to the effect of surgery</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Sixty‐three patients with Crohn's disease showed a high incidence of nutritional deficiencies as judged by laboratory tests. Malabsorption of fat (33 per cent) and vitamin B12 (60 per cent) was not sufficiently severe to account for the malnutrition. Malnutrition was especially severe in unoperated patients with active disease, whereas malabsorption was prominent in patients with recurrent disease after resection although they had less active disease and less severe nutritional deficits. Surgery should not be withheld from a malnourished patient for fear of inducing further malnutrition; excision of toxic inflammatory disease will not only improve the immediate outlook but will also reduce the severity of further recurrences. Xylose‐excretion tests give a spurious impression of malabsorption in Crohn's disease, possibly as a result of occult renal impairment, and should be abandoned.</description><subject>Crohn Disease - blood</subject><subject>Crohn Disease - complications</subject><subject>Crohn Disease - surgery</subject><subject>Fats - analysis</subject><subject>Feces - analysis</subject><subject>Female</subject><subject>Folic Acid - blood</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Ileum - surgery</subject><subject>Intestinal Absorption</subject><subject>Malabsorption Syndromes - etiology</subject><subject>Male</subject><subject>Nutrition Disorders - etiology</subject><subject>Serum Albumin - analysis</subject><subject>Vitamin B 12 - blood</subject><subject>Xylose - metabolism</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9P2zAUxy20CUrhuhuST9sp7DmvdpLjqDagY3Ao02AXy3ZeVkOadHYi6H9PoFU5PX3f98fhw9gnAacCIP1qH-KpyAHUIITYYyOBSiapUPkHNgKALBGY4gE7jPEBQCDIdJ_tT1QuC1Qjdv_L1E3fBd_5tuGmKfnS1MbGNqzePr7hLrSL5kvkpY9kIvEn3y14oIoCNY541_JuQZyqilzH24rHPvyjsD5iHytTRzre3jH7_eP77fQiubo5v5x-u0ocYiGSXIErLZB0hZOQWimRCmsBLZIrJwpKa60qYUJFXqavYQmVAmlQYoUiwzH7vNldhfZ_T7HTSx8d1bVpqO2jzkWeijzDIXiyDfZ2SaVeBb80Ya23LAa_2PhPvqb1zhagX0HrAbR-B63PZvN3NXSTTdfHjp53XRMetcowk_rP9bn-eTcrCinm-i--AIcUgSc</recordid><startdate>197302</startdate><enddate>197302</enddate><creator>Dyer, N. H.</creator><creator>Dawson, A. M.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197302</creationdate><title>Malnutrition and malabsorption in crohn's disease with reference to the effect of surgery</title><author>Dyer, N. H. ; Dawson, A. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3391-860cdb0e5c9c502b553e9bb03b3ecd460dbbb6d04e98d260cd50f605a353f3173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Crohn Disease - blood</topic><topic>Crohn Disease - complications</topic><topic>Crohn Disease - surgery</topic><topic>Fats - analysis</topic><topic>Feces - analysis</topic><topic>Female</topic><topic>Folic Acid - blood</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Ileum - surgery</topic><topic>Intestinal Absorption</topic><topic>Malabsorption Syndromes - etiology</topic><topic>Male</topic><topic>Nutrition Disorders - etiology</topic><topic>Serum Albumin - analysis</topic><topic>Vitamin B 12 - blood</topic><topic>Xylose - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dyer, N. H.</creatorcontrib><creatorcontrib>Dawson, A. M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dyer, N. H.</au><au>Dawson, A. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malnutrition and malabsorption in crohn's disease with reference to the effect of surgery</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1973-02</date><risdate>1973</risdate><volume>60</volume><issue>2</issue><spage>134</spage><epage>140</epage><pages>134-140</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><abstract>Sixty‐three patients with Crohn's disease showed a high incidence of nutritional deficiencies as judged by laboratory tests. Malabsorption of fat (33 per cent) and vitamin B12 (60 per cent) was not sufficiently severe to account for the malnutrition. Malnutrition was especially severe in unoperated patients with active disease, whereas malabsorption was prominent in patients with recurrent disease after resection although they had less active disease and less severe nutritional deficits. Surgery should not be withheld from a malnourished patient for fear of inducing further malnutrition; excision of toxic inflammatory disease will not only improve the immediate outlook but will also reduce the severity of further recurrences. Xylose‐excretion tests give a spurious impression of malabsorption in Crohn's disease, possibly as a result of occult renal impairment, and should be abandoned.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>4685936</pmid><doi>10.1002/bjs.1800600211</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1323 |
| ispartof | British journal of surgery, 1973-02, Vol.60 (2), p.134-140 |
| issn | 0007-1323 1365-2168 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Crohn Disease - blood Crohn Disease - complications Crohn Disease - surgery Fats - analysis Feces - analysis Female Folic Acid - blood Hemoglobins - analysis Humans Ileum - surgery Intestinal Absorption Malabsorption Syndromes - etiology Male Nutrition Disorders - etiology Serum Albumin - analysis Vitamin B 12 - blood Xylose - metabolism |
| title | Malnutrition and malabsorption in crohn's disease with reference to the effect of surgery |
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