Serum copper in Hodgkin's disease in children
A study of 37 cases of Hodgkin's disease in children, including 669 serum copper levels (SCL), has demonstrated a clinically useful relationship between SCL and the disease process. SCL are high in untreated Hodgkin's disease, falling to normal levels when the clinical findings change from...
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Veröffentlicht in: | Cancer 1973-02, Vol.31 (2), p.303-315 |
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description | A study of 37 cases of Hodgkin's disease in children, including 669 serum copper levels (SCL), has demonstrated a clinically useful relationship between SCL and the disease process. SCL are high in untreated Hodgkin's disease, falling to normal levels when the clinical findings change from recognized disease to unrecognized or absent disease. SCL rises to abnormal levels upon relapse, and provides an indication of relapse before clinical findings. These relations are even more pronounced in Stage IV Hodgkin's disease and with systemic symptoms due to the disease, and are not present in the limited number of lymphocytic predominance cases. A typical case reflecting response of SCL to treatment and predicting relapse is included, as well as an exceptional case with nonresponsive SCL and unusual clinical and histologic pattern. Serum copper levels provide a valuable aid in the determination and evaluation of activity in Hodgkin's disease. |
doi_str_mv | 10.1002/1097-0142(197302)31:2<303::AID-CNCR2820310206>3.0.CO;2-8 |
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SCL are high in untreated Hodgkin's disease, falling to normal levels when the clinical findings change from recognized disease to unrecognized or absent disease. SCL rises to abnormal levels upon relapse, and provides an indication of relapse before clinical findings. These relations are even more pronounced in Stage IV Hodgkin's disease and with systemic symptoms due to the disease, and are not present in the limited number of lymphocytic predominance cases. A typical case reflecting response of SCL to treatment and predicting relapse is included, as well as an exceptional case with nonresponsive SCL and unusual clinical and histologic pattern. Serum copper levels provide a valuable aid in the determination and evaluation of activity in Hodgkin's disease.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(197302)31:2<303::AID-CNCR2820310206>3.0.CO;2-8</identifier><identifier>PMID: 4687877</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Child ; Child, Preschool ; Copper - blood ; Copper - metabolism ; Female ; Follow-Up Studies ; Hodgkin Disease - blood ; Hodgkin Disease - diagnosis ; Hodgkin Disease - metabolism ; Hodgkin Disease - therapy ; Humans ; Male ; Recurrence ; Remission, Spontaneous ; Time Factors</subject><ispartof>Cancer, 1973-02, Vol.31 (2), p.303-315</ispartof><rights>Copyright © 1973 American Cancer Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4606-98001d19e840340b04943462579cefd3cbb1982baa81a02a5325317183ee37d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4687877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tessmer, Carl F.</creatorcontrib><creatorcontrib>Hrgovcic, Martin</creatorcontrib><creatorcontrib>Wilbur, Jordan</creatorcontrib><title>Serum copper in Hodgkin's disease in children</title><title>Cancer</title><addtitle>Cancer</addtitle><description>A study of 37 cases of Hodgkin's disease in children, including 669 serum copper levels (SCL), has demonstrated a clinically useful relationship between SCL and the disease process. SCL are high in untreated Hodgkin's disease, falling to normal levels when the clinical findings change from recognized disease to unrecognized or absent disease. SCL rises to abnormal levels upon relapse, and provides an indication of relapse before clinical findings. These relations are even more pronounced in Stage IV Hodgkin's disease and with systemic symptoms due to the disease, and are not present in the limited number of lymphocytic predominance cases. A typical case reflecting response of SCL to treatment and predicting relapse is included, as well as an exceptional case with nonresponsive SCL and unusual clinical and histologic pattern. Serum copper levels provide a valuable aid in the determination and evaluation of activity in Hodgkin's disease.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Copper - blood</subject><subject>Copper - metabolism</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hodgkin Disease - blood</subject><subject>Hodgkin Disease - diagnosis</subject><subject>Hodgkin Disease - metabolism</subject><subject>Hodgkin Disease - therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Recurrence</subject><subject>Remission, Spontaneous</subject><subject>Time Factors</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFtLAzEQhYMotVZ_gtAnLw9bZzLZTbaKWNZLC8WCF-hb2Euqq9vdurFI_70pLQV9EHzJkDlnzgwfY1cIHQTgZwih9AAFP8FQEvBTwi6_IKButze49qL76IErDoTAIbikDnSi0Tn31BZrbka3WRMAlOcLGu-yPWvf3FdynxqsIQIllZRN5j2aej5tp9VsZup2Xrb7VfbynpfHtp3l1sTWLJvpa15ktSn32c4kLqw5WNcWe769eYr63nB0N4h6Qy8VAQReqAAww9AoASQgAREKEgH3ZZiaSUZpkmCoeBLHCmPgsU_uKpSoyBiSGVCLHa1yZ3X1MTf2U09zm5qiiEtTza1WqNBxImccr4xpXVlbm4me1fk0rhcaQS9J6iUOvcShVyQ1oXYPkNaOpP5JUpMGHY2cQbnow_UN82Rqsk3wGp3T05X-lRdm8Y-9f679pdA3pvCMLQ</recordid><startdate>197302</startdate><enddate>197302</enddate><creator>Tessmer, Carl F.</creator><creator>Hrgovcic, Martin</creator><creator>Wilbur, Jordan</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197302</creationdate><title>Serum copper in Hodgkin's disease in children</title><author>Tessmer, Carl F. ; Hrgovcic, Martin ; Wilbur, Jordan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4606-98001d19e840340b04943462579cefd3cbb1982baa81a02a5325317183ee37d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Copper - blood</topic><topic>Copper - metabolism</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hodgkin Disease - blood</topic><topic>Hodgkin Disease - diagnosis</topic><topic>Hodgkin Disease - metabolism</topic><topic>Hodgkin Disease - therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Recurrence</topic><topic>Remission, Spontaneous</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tessmer, Carl F.</creatorcontrib><creatorcontrib>Hrgovcic, Martin</creatorcontrib><creatorcontrib>Wilbur, Jordan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tessmer, Carl F.</au><au>Hrgovcic, Martin</au><au>Wilbur, Jordan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum copper in Hodgkin's disease in children</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1973-02</date><risdate>1973</risdate><volume>31</volume><issue>2</issue><spage>303</spage><epage>315</epage><pages>303-315</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>A study of 37 cases of Hodgkin's disease in children, including 669 serum copper levels (SCL), has demonstrated a clinically useful relationship between SCL and the disease process. SCL are high in untreated Hodgkin's disease, falling to normal levels when the clinical findings change from recognized disease to unrecognized or absent disease. SCL rises to abnormal levels upon relapse, and provides an indication of relapse before clinical findings. These relations are even more pronounced in Stage IV Hodgkin's disease and with systemic symptoms due to the disease, and are not present in the limited number of lymphocytic predominance cases. A typical case reflecting response of SCL to treatment and predicting relapse is included, as well as an exceptional case with nonresponsive SCL and unusual clinical and histologic pattern. Serum copper levels provide a valuable aid in the determination and evaluation of activity in Hodgkin's disease.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>4687877</pmid><doi>10.1002/1097-0142(197302)31:2<303::AID-CNCR2820310206>3.0.CO;2-8</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Child Child, Preschool Copper - blood Copper - metabolism Female Follow-Up Studies Hodgkin Disease - blood Hodgkin Disease - diagnosis Hodgkin Disease - metabolism Hodgkin Disease - therapy Humans Male Recurrence Remission, Spontaneous Time Factors |
title | Serum copper in Hodgkin's disease in children |
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