Serum copper in Hodgkin's disease in children

A study of 37 cases of Hodgkin's disease in children, including 669 serum copper levels (SCL), has demonstrated a clinically useful relationship between SCL and the disease process. SCL are high in untreated Hodgkin's disease, falling to normal levels when the clinical findings change from...

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Veröffentlicht in:Cancer 1973-02, Vol.31 (2), p.303-315
Hauptverfasser: Tessmer, Carl F., Hrgovcic, Martin, Wilbur, Jordan
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container_title Cancer
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creator Tessmer, Carl F.
Hrgovcic, Martin
Wilbur, Jordan
description A study of 37 cases of Hodgkin's disease in children, including 669 serum copper levels (SCL), has demonstrated a clinically useful relationship between SCL and the disease process. SCL are high in untreated Hodgkin's disease, falling to normal levels when the clinical findings change from recognized disease to unrecognized or absent disease. SCL rises to abnormal levels upon relapse, and provides an indication of relapse before clinical findings. These relations are even more pronounced in Stage IV Hodgkin's disease and with systemic symptoms due to the disease, and are not present in the limited number of lymphocytic predominance cases. A typical case reflecting response of SCL to treatment and predicting relapse is included, as well as an exceptional case with nonresponsive SCL and unusual clinical and histologic pattern. Serum copper levels provide a valuable aid in the determination and evaluation of activity in Hodgkin's disease.
doi_str_mv 10.1002/1097-0142(197302)31:2<303::AID-CNCR2820310206>3.0.CO;2-8
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SCL are high in untreated Hodgkin's disease, falling to normal levels when the clinical findings change from recognized disease to unrecognized or absent disease. SCL rises to abnormal levels upon relapse, and provides an indication of relapse before clinical findings. These relations are even more pronounced in Stage IV Hodgkin's disease and with systemic symptoms due to the disease, and are not present in the limited number of lymphocytic predominance cases. A typical case reflecting response of SCL to treatment and predicting relapse is included, as well as an exceptional case with nonresponsive SCL and unusual clinical and histologic pattern. 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subjects Adolescent
Child
Child, Preschool
Copper - blood
Copper - metabolism
Female
Follow-Up Studies
Hodgkin Disease - blood
Hodgkin Disease - diagnosis
Hodgkin Disease - metabolism
Hodgkin Disease - therapy
Humans
Male
Recurrence
Remission, Spontaneous
Time Factors
title Serum copper in Hodgkin's disease in children
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