Increased Activity of Renal Glutaminases in Guinea Pig Following Prolonged Administration of Acid or Alkali.
Summary Increased activity of the enzymes involved in ammonia metabolism in the kidneys of guinea pigs was produced by prolonged treatment with acid or alkali. When the results were expressed on a per cell basis, Glutaminase I was increased in acidosis while in alkalosis Glutaminases I and II and th...
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Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1956-11, Vol.93 (2), p.284-287 |
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container_title | Experimental biology and medicine (Maywood, N.J.) |
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creator | Goldstein, Leon Baerle, R. Richterich-van Dearborn, Earl H. |
description | Summary
Increased activity of the enzymes involved in ammonia metabolism in the kidneys of guinea pigs was produced by prolonged treatment with acid or alkali. When the results were expressed on a per cell basis, Glutaminase I was increased in acidosis while in alkalosis Glutaminases I and II and the Glutamine synthesizing enzyme were increased. These increases in activity are suggestive of enzyme induction though all the criteria for this process have not yet been fulfilled. |
doi_str_mv | 10.3181/00379727-93-22733 |
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Increased activity of the enzymes involved in ammonia metabolism in the kidneys of guinea pigs was produced by prolonged treatment with acid or alkali. When the results were expressed on a per cell basis, Glutaminase I was increased in acidosis while in alkalosis Glutaminases I and II and the Glutamine synthesizing enzyme were increased. These increases in activity are suggestive of enzyme induction though all the criteria for this process have not yet been fulfilled.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-93-22733</identifier><identifier>PMID: 13379488</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acidosis ; Alkalies ; Alkalosis ; Amidohydrolases ; Glutaminase ; Guinea Pigs ; Kidney - metabolism ; Old Medline ; Psychomotor Agitation</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1956-11, Vol.93 (2), p.284-287</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-b66a929e787c8eb42a3f5a64b18000a91b5fa58819ce9b253814781cf86927b13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13379488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goldstein, Leon</creatorcontrib><creatorcontrib>Baerle, R. Richterich-van</creatorcontrib><creatorcontrib>Dearborn, Earl H.</creatorcontrib><title>Increased Activity of Renal Glutaminases in Guinea Pig Following Prolonged Administration of Acid or Alkali.</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
Increased activity of the enzymes involved in ammonia metabolism in the kidneys of guinea pigs was produced by prolonged treatment with acid or alkali. When the results were expressed on a per cell basis, Glutaminase I was increased in acidosis while in alkalosis Glutaminases I and II and the Glutamine synthesizing enzyme were increased. These increases in activity are suggestive of enzyme induction though all the criteria for this process have not yet been fulfilled.</description><subject>Acidosis</subject><subject>Alkalies</subject><subject>Alkalosis</subject><subject>Amidohydrolases</subject><subject>Glutaminase</subject><subject>Guinea Pigs</subject><subject>Kidney - metabolism</subject><subject>Old Medline</subject><subject>Psychomotor Agitation</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1956</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFPwyAYhonRuDn9AV4MJ2-dUNoCx2Zxc8kSF6NnQhldmBQmtJr9e1s3483Td_ie9zk8ANxiNCWY4QeECOU0pQknSZpSQs7AGOckT0jB-TkYD_9kAEbgKsYdQjinaXEJRpj0w4yxMbBLp4KWUW9gqVrzadoD9DV80U5auLBdKxvj-neExsFFZ5yWcG22cO6t9V_GbeE6eOvddhBsetbENsjWeDdoSmU20AdY2ndpzfQaXNTSRn1zuhPwNn98nT0lq-fFclauEkUIa5OqKCRPuaaMKqarLJWkzmWRVZghhCTHVV7LnDHMleZVmhOGM8qwqlnBU1phMgH3R-8--I9Ox1Y0JiptrXTad1EwTIsM57wH8RFUwccYdC32wTQyHARGYkgsfhMLTsRP4n5zd5J3VaM3f4tT0x6YHoEot1rsfBf6lvEf4ze4VIPU</recordid><startdate>195611</startdate><enddate>195611</enddate><creator>Goldstein, Leon</creator><creator>Baerle, R. Richterich-van</creator><creator>Dearborn, Earl H.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195611</creationdate><title>Increased Activity of Renal Glutaminases in Guinea Pig Following Prolonged Administration of Acid or Alkali.</title><author>Goldstein, Leon ; Baerle, R. Richterich-van ; Dearborn, Earl H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-b66a929e787c8eb42a3f5a64b18000a91b5fa58819ce9b253814781cf86927b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1956</creationdate><topic>Acidosis</topic><topic>Alkalies</topic><topic>Alkalosis</topic><topic>Amidohydrolases</topic><topic>Glutaminase</topic><topic>Guinea Pigs</topic><topic>Kidney - metabolism</topic><topic>Old Medline</topic><topic>Psychomotor Agitation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goldstein, Leon</creatorcontrib><creatorcontrib>Baerle, R. Richterich-van</creatorcontrib><creatorcontrib>Dearborn, Earl H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goldstein, Leon</au><au>Baerle, R. Richterich-van</au><au>Dearborn, Earl H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Activity of Renal Glutaminases in Guinea Pig Following Prolonged Administration of Acid or Alkali.</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1956-11</date><risdate>1956</risdate><volume>93</volume><issue>2</issue><spage>284</spage><epage>287</epage><pages>284-287</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
Increased activity of the enzymes involved in ammonia metabolism in the kidneys of guinea pigs was produced by prolonged treatment with acid or alkali. When the results were expressed on a per cell basis, Glutaminase I was increased in acidosis while in alkalosis Glutaminases I and II and the Glutamine synthesizing enzyme were increased. These increases in activity are suggestive of enzyme induction though all the criteria for this process have not yet been fulfilled.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>13379488</pmid><doi>10.3181/00379727-93-22733</doi><tpages>4</tpages></addata></record> |
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source | MEDLINE; Alma/SFX Local Collection |
subjects | Acidosis Alkalies Alkalosis Amidohydrolases Glutaminase Guinea Pigs Kidney - metabolism Old Medline Psychomotor Agitation |
title | Increased Activity of Renal Glutaminases in Guinea Pig Following Prolonged Administration of Acid or Alkali. |
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