Increased Activity of Renal Glutaminases in Guinea Pig Following Prolonged Administration of Acid or Alkali.

Summary Increased activity of the enzymes involved in ammonia metabolism in the kidneys of guinea pigs was produced by prolonged treatment with acid or alkali. When the results were expressed on a per cell basis, Glutaminase I was increased in acidosis while in alkalosis Glutaminases I and II and th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1956-11, Vol.93 (2), p.284-287
Hauptverfasser: Goldstein, Leon, Baerle, R. Richterich-van, Dearborn, Earl H.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 287
container_issue 2
container_start_page 284
container_title Experimental biology and medicine (Maywood, N.J.)
container_volume 93
creator Goldstein, Leon
Baerle, R. Richterich-van
Dearborn, Earl H.
description Summary Increased activity of the enzymes involved in ammonia metabolism in the kidneys of guinea pigs was produced by prolonged treatment with acid or alkali. When the results were expressed on a per cell basis, Glutaminase I was increased in acidosis while in alkalosis Glutaminases I and II and the Glutamine synthesizing enzyme were increased. These increases in activity are suggestive of enzyme induction though all the criteria for this process have not yet been fulfilled.
doi_str_mv 10.3181/00379727-93-22733
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81764159</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.3181_00379727-93-22733</sage_id><sourcerecordid>81764159</sourcerecordid><originalsourceid>FETCH-LOGICAL-c338t-b66a929e787c8eb42a3f5a64b18000a91b5fa58819ce9b253814781cf86927b13</originalsourceid><addsrcrecordid>eNp9kEFPwyAYhonRuDn9AV4MJ2-dUNoCx2Zxc8kSF6NnQhldmBQmtJr9e1s3483Td_ie9zk8ANxiNCWY4QeECOU0pQknSZpSQs7AGOckT0jB-TkYD_9kAEbgKsYdQjinaXEJRpj0w4yxMbBLp4KWUW9gqVrzadoD9DV80U5auLBdKxvj-neExsFFZ5yWcG22cO6t9V_GbeE6eOvddhBsetbENsjWeDdoSmU20AdY2ndpzfQaXNTSRn1zuhPwNn98nT0lq-fFclauEkUIa5OqKCRPuaaMKqarLJWkzmWRVZghhCTHVV7LnDHMleZVmhOGM8qwqlnBU1phMgH3R-8--I9Ox1Y0JiptrXTad1EwTIsM57wH8RFUwccYdC32wTQyHARGYkgsfhMLTsRP4n5zd5J3VaM3f4tT0x6YHoEot1rsfBf6lvEf4ze4VIPU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81764159</pqid></control><display><type>article</type><title>Increased Activity of Renal Glutaminases in Guinea Pig Following Prolonged Administration of Acid or Alkali.</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Goldstein, Leon ; Baerle, R. Richterich-van ; Dearborn, Earl H.</creator><creatorcontrib>Goldstein, Leon ; Baerle, R. Richterich-van ; Dearborn, Earl H.</creatorcontrib><description>Summary Increased activity of the enzymes involved in ammonia metabolism in the kidneys of guinea pigs was produced by prolonged treatment with acid or alkali. When the results were expressed on a per cell basis, Glutaminase I was increased in acidosis while in alkalosis Glutaminases I and II and the Glutamine synthesizing enzyme were increased. These increases in activity are suggestive of enzyme induction though all the criteria for this process have not yet been fulfilled.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-93-22733</identifier><identifier>PMID: 13379488</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acidosis ; Alkalies ; Alkalosis ; Amidohydrolases ; Glutaminase ; Guinea Pigs ; Kidney - metabolism ; Old Medline ; Psychomotor Agitation</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1956-11, Vol.93 (2), p.284-287</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-b66a929e787c8eb42a3f5a64b18000a91b5fa58819ce9b253814781cf86927b13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13379488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goldstein, Leon</creatorcontrib><creatorcontrib>Baerle, R. Richterich-van</creatorcontrib><creatorcontrib>Dearborn, Earl H.</creatorcontrib><title>Increased Activity of Renal Glutaminases in Guinea Pig Following Prolonged Administration of Acid or Alkali.</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary Increased activity of the enzymes involved in ammonia metabolism in the kidneys of guinea pigs was produced by prolonged treatment with acid or alkali. When the results were expressed on a per cell basis, Glutaminase I was increased in acidosis while in alkalosis Glutaminases I and II and the Glutamine synthesizing enzyme were increased. These increases in activity are suggestive of enzyme induction though all the criteria for this process have not yet been fulfilled.</description><subject>Acidosis</subject><subject>Alkalies</subject><subject>Alkalosis</subject><subject>Amidohydrolases</subject><subject>Glutaminase</subject><subject>Guinea Pigs</subject><subject>Kidney - metabolism</subject><subject>Old Medline</subject><subject>Psychomotor Agitation</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1956</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFPwyAYhonRuDn9AV4MJ2-dUNoCx2Zxc8kSF6NnQhldmBQmtJr9e1s3483Td_ie9zk8ANxiNCWY4QeECOU0pQknSZpSQs7AGOckT0jB-TkYD_9kAEbgKsYdQjinaXEJRpj0w4yxMbBLp4KWUW9gqVrzadoD9DV80U5auLBdKxvj-neExsFFZ5yWcG22cO6t9V_GbeE6eOvddhBsetbENsjWeDdoSmU20AdY2ndpzfQaXNTSRn1zuhPwNn98nT0lq-fFclauEkUIa5OqKCRPuaaMKqarLJWkzmWRVZghhCTHVV7LnDHMleZVmhOGM8qwqlnBU1phMgH3R-8--I9Ox1Y0JiptrXTad1EwTIsM57wH8RFUwccYdC32wTQyHARGYkgsfhMLTsRP4n5zd5J3VaM3f4tT0x6YHoEot1rsfBf6lvEf4ze4VIPU</recordid><startdate>195611</startdate><enddate>195611</enddate><creator>Goldstein, Leon</creator><creator>Baerle, R. Richterich-van</creator><creator>Dearborn, Earl H.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195611</creationdate><title>Increased Activity of Renal Glutaminases in Guinea Pig Following Prolonged Administration of Acid or Alkali.</title><author>Goldstein, Leon ; Baerle, R. Richterich-van ; Dearborn, Earl H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-b66a929e787c8eb42a3f5a64b18000a91b5fa58819ce9b253814781cf86927b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1956</creationdate><topic>Acidosis</topic><topic>Alkalies</topic><topic>Alkalosis</topic><topic>Amidohydrolases</topic><topic>Glutaminase</topic><topic>Guinea Pigs</topic><topic>Kidney - metabolism</topic><topic>Old Medline</topic><topic>Psychomotor Agitation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goldstein, Leon</creatorcontrib><creatorcontrib>Baerle, R. Richterich-van</creatorcontrib><creatorcontrib>Dearborn, Earl H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goldstein, Leon</au><au>Baerle, R. Richterich-van</au><au>Dearborn, Earl H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Activity of Renal Glutaminases in Guinea Pig Following Prolonged Administration of Acid or Alkali.</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1956-11</date><risdate>1956</risdate><volume>93</volume><issue>2</issue><spage>284</spage><epage>287</epage><pages>284-287</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary Increased activity of the enzymes involved in ammonia metabolism in the kidneys of guinea pigs was produced by prolonged treatment with acid or alkali. When the results were expressed on a per cell basis, Glutaminase I was increased in acidosis while in alkalosis Glutaminases I and II and the Glutamine synthesizing enzyme were increased. These increases in activity are suggestive of enzyme induction though all the criteria for this process have not yet been fulfilled.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>13379488</pmid><doi>10.3181/00379727-93-22733</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0037-9727
ispartof Experimental biology and medicine (Maywood, N.J.), 1956-11, Vol.93 (2), p.284-287
issn 0037-9727
1535-3702
1535-3699
language eng
recordid cdi_proquest_miscellaneous_81764159
source MEDLINE; Alma/SFX Local Collection
subjects Acidosis
Alkalies
Alkalosis
Amidohydrolases
Glutaminase
Guinea Pigs
Kidney - metabolism
Old Medline
Psychomotor Agitation
title Increased Activity of Renal Glutaminases in Guinea Pig Following Prolonged Administration of Acid or Alkali.
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T05%3A04%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20Activity%20of%20Renal%20Glutaminases%20in%20Guinea%20Pig%20Following%20Prolonged%20Administration%20of%20Acid%20or%20Alkali.&rft.jtitle=Experimental%20biology%20and%20medicine%20(Maywood,%20N.J.)&rft.au=Goldstein,%20Leon&rft.date=1956-11&rft.volume=93&rft.issue=2&rft.spage=284&rft.epage=287&rft.pages=284-287&rft.issn=0037-9727&rft.eissn=1535-3699&rft_id=info:doi/10.3181/00379727-93-22733&rft_dat=%3Cproquest_cross%3E81764159%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81764159&rft_id=info:pmid/13379488&rft_sage_id=10.3181_00379727-93-22733&rfr_iscdi=true