Human Umbilical Cord-Derived Mesenchymal Stromal Cells Differentiate Into Functional Schwann Cells That Sustain Peripheral Nerve Regeneration

Human umbilical cord-derived mesenchymal stromal cells (UC-MSCs) that are available from cell banks can be induced to differentiate into various cell types, thereby making them practical potential sources for cell-based therapies. In injured peripheral nerves, Schwann cells (SCs) contribute to funct...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 2010-09, Vol.69 (9), p.973-985
Hauptverfasser:	Matsuse, Dai, Kitada, Masaaki, Kohama, Misaki, Nishikawa, Kouki, Makinoshima, Hideki, Wakao, Shohei, Fujiyoshi, Yoshinori, Heike, Toshio, Nakahata, Tatsutoshi, Akutsu, Hidenori, Umezawa, Akihiro, Harigae, Hideo, Kira, Jun-ichi, Dezawa, Mari
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Axons - metabolism Axons - ultrastructure Biomarkers - metabolism Cell Differentiation - physiology Humans Intercellular Signaling Peptides and Proteins - pharmacology Male Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - physiology Nerve Regeneration - physiology Peripheral Nerves - physiology Rats Rats, Wistar Recovery of Function - physiology Schwann Cells - cytology Schwann Cells - physiology Sciatic Nerve - pathology Sciatic Nerve - surgery Stem Cell Transplantation Stromal Cells - cytology Stromal Cells - drug effects Stromal Cells - physiology Stromal Cells - transplantation Tretinoin - pharmacology Umbilical Cord - cytology
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