Effect of three anthelmentics on disposition kinetics of florfenicol in goats
The pharmacokinetic aspects of florfenicol (FLO) were investigated via intravenous (I.V.) and intramuscular (I.M.) injections in five goats at a dose of 20 mg kg −1 b.wt. Animals were pre-treated with albendazole orally in a dose of 2.5 mg kg −1 b.wt, ivermectin or rafoxanide subcutaneously in a dos...
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| Veröffentlicht in: | Food and chemical toxicology 2010-12, Vol.48 (12), p.3340-3344 |
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| creator | Atef, M. El-Gendi, A.Y.I. Amer, Aziza M. El-Aty, A.M. Abd |
| description | The pharmacokinetic aspects of florfenicol (FLO) were investigated via intravenous (I.V.) and intramuscular (I.M.) injections in five goats at a dose of 20
mg
kg
−1
b.wt. Animals were pre-treated with albendazole orally in a dose of 2.5
mg
kg
−1
b.wt, ivermectin or rafoxanide subcutaneously in a dose 0.2 and 7.5
mg
kg
−1
b.wt, respectively. Florfenicol was injected intramuscularly two hours following anthelmentic administration and blood samples were taken by jugular venapuncture at standardized intervals. The concentrations of florfenicol (FLO) in serum were determined by high performance liquid chromatography (HPLC) method. The obtained results revealed that ivermectin administration did not induce a significant difference in serum florfenicol concentration between anthelmentic-treated and non-treated goats. On the other hand, goats pre-treated with rafoxanide or albendazole showed a significant decrease in serum florfenicol level as compared to non-anthementic treated goats. The absorption half-life (
t
½ab),
C
max, AUMC, AUC and systemic bioavailability (F%) are significantly decreased, whereas elimination half-life (
t
½el) and MRT are increased in goats pre-treated by the three tested anthementics. |
| doi_str_mv | 10.1016/j.fct.2010.08.039 |
| format | Article |
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mg
kg
−1
b.wt. Animals were pre-treated with albendazole orally in a dose of 2.5
mg
kg
−1
b.wt, ivermectin or rafoxanide subcutaneously in a dose 0.2 and 7.5
mg
kg
−1
b.wt, respectively. Florfenicol was injected intramuscularly two hours following anthelmentic administration and blood samples were taken by jugular venapuncture at standardized intervals. The concentrations of florfenicol (FLO) in serum were determined by high performance liquid chromatography (HPLC) method. The obtained results revealed that ivermectin administration did not induce a significant difference in serum florfenicol concentration between anthelmentic-treated and non-treated goats. On the other hand, goats pre-treated with rafoxanide or albendazole showed a significant decrease in serum florfenicol level as compared to non-anthementic treated goats. The absorption half-life (
t
½ab),
C
max, AUMC, AUC and systemic bioavailability (F%) are significantly decreased, whereas elimination half-life (
t
½el) and MRT are increased in goats pre-treated by the three tested anthementics.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2010.08.039</identifier><identifier>PMID: 20863870</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Albendazole ; Albendazole - pharmacology ; Animals ; Anthelmintics - pharmacology ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - pharmacokinetics ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Cross-Over Studies ; Drug Interactions ; Drug toxicity and drugs side effects treatment ; Female ; Florfenicol ; Goats - metabolism ; Half-Life ; Injections, Intramuscular ; Injections, Intravenous ; Interaction ; Ivermectin ; Ivermectin - pharmacology ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Pharmacokinetics ; Pharmacology. Drug treatments ; Rafoxanide ; Rafoxanide - pharmacology ; Reference Standards ; Thiamphenicol - administration & dosage ; Thiamphenicol - analogs & derivatives ; Thiamphenicol - pharmacokinetics</subject><ispartof>Food and chemical toxicology, 2010-12, Vol.48 (12), p.3340-3344</ispartof><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-9434a2381b5589825f467f4a17ee972095bcbda07608e0900f30c14a77250eb33</citedby><cites>FETCH-LOGICAL-c480t-9434a2381b5589825f467f4a17ee972095bcbda07608e0900f30c14a77250eb33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fct.2010.08.039$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23428616$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20863870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Atef, M.</creatorcontrib><creatorcontrib>El-Gendi, A.Y.I.</creatorcontrib><creatorcontrib>Amer, Aziza M.</creatorcontrib><creatorcontrib>El-Aty, A.M. Abd</creatorcontrib><title>Effect of three anthelmentics on disposition kinetics of florfenicol in goats</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>The pharmacokinetic aspects of florfenicol (FLO) were investigated via intravenous (I.V.) and intramuscular (I.M.) injections in five goats at a dose of 20
mg
kg
−1
b.wt. Animals were pre-treated with albendazole orally in a dose of 2.5
mg
kg
−1
b.wt, ivermectin or rafoxanide subcutaneously in a dose 0.2 and 7.5
mg
kg
−1
b.wt, respectively. Florfenicol was injected intramuscularly two hours following anthelmentic administration and blood samples were taken by jugular venapuncture at standardized intervals. The concentrations of florfenicol (FLO) in serum were determined by high performance liquid chromatography (HPLC) method. The obtained results revealed that ivermectin administration did not induce a significant difference in serum florfenicol concentration between anthelmentic-treated and non-treated goats. On the other hand, goats pre-treated with rafoxanide or albendazole showed a significant decrease in serum florfenicol level as compared to non-anthementic treated goats. The absorption half-life (
t
½ab),
C
max, AUMC, AUC and systemic bioavailability (F%) are significantly decreased, whereas elimination half-life (
t
½el) and MRT are increased in goats pre-treated by the three tested anthementics.</description><subject>Albendazole</subject><subject>Albendazole - pharmacology</subject><subject>Animals</subject><subject>Anthelmintics - pharmacology</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cross-Over Studies</subject><subject>Drug Interactions</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Florfenicol</subject><subject>Goats - metabolism</subject><subject>Half-Life</subject><subject>Injections, Intramuscular</subject><subject>Injections, Intravenous</subject><subject>Interaction</subject><subject>Ivermectin</subject><subject>Ivermectin - pharmacology</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Rafoxanide</subject><subject>Rafoxanide - pharmacology</subject><subject>Reference Standards</subject><subject>Thiamphenicol - administration & dosage</subject><subject>Thiamphenicol - analogs & derivatives</subject><subject>Thiamphenicol - pharmacokinetics</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT1vHCEQhlEUKz47-QFprG2iVHseYBdYubIsf0mO3Ng1Ytkh5rIHF-As-d8H6y5O51TA6HlHMw-EfKWwpEDF6WrpbFkyqG9QS-DDB7KgSvJW8J5-JAtgUrVioP0hOcp5BQCSSvGJHDJQgisJC_Lj0jm0pYmuKU8JsTGhPOG8xlC8zU0MzeTzJmZffL3_8gF3dde4OSaHwds4Nz40P6Mp-TM5cGbO-GV_HpPHq8uHi5v27v769uL8rrWdgtIOHe8M44qOfa8GxXrXCek6QyXiIBkM_WjHyYAUoBAGAMfB0s5IyXrAkfNj8n3Xd5Pi7y3motc-W5xnEzBus1Z1TZCcsf-SUjChuOxUJemOtCnmnNDpTfJrk140Bf2qW6901a1fdWtQuuqumZN99-24xukt8ddvBb7tAZOtmV0ywfr8j-MdU4KKyp3tOKzWnj0mna3HYHHyqX6PnqJ_Z4w_23mbnw</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Atef, M.</creator><creator>El-Gendi, A.Y.I.</creator><creator>Amer, Aziza M.</creator><creator>El-Aty, A.M. Abd</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20101201</creationdate><title>Effect of three anthelmentics on disposition kinetics of florfenicol in goats</title><author>Atef, M. ; El-Gendi, A.Y.I. ; Amer, Aziza M. ; El-Aty, A.M. Abd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-9434a2381b5589825f467f4a17ee972095bcbda07608e0900f30c14a77250eb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Albendazole</topic><topic>Albendazole - pharmacology</topic><topic>Animals</topic><topic>Anthelmintics - pharmacology</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cross-Over Studies</topic><topic>Drug Interactions</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Florfenicol</topic><topic>Goats - metabolism</topic><topic>Half-Life</topic><topic>Injections, Intramuscular</topic><topic>Injections, Intravenous</topic><topic>Interaction</topic><topic>Ivermectin</topic><topic>Ivermectin - pharmacology</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Rafoxanide</topic><topic>Rafoxanide - pharmacology</topic><topic>Reference Standards</topic><topic>Thiamphenicol - administration & dosage</topic><topic>Thiamphenicol - analogs & derivatives</topic><topic>Thiamphenicol - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atef, M.</creatorcontrib><creatorcontrib>El-Gendi, A.Y.I.</creatorcontrib><creatorcontrib>Amer, Aziza M.</creatorcontrib><creatorcontrib>El-Aty, A.M. Abd</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atef, M.</au><au>El-Gendi, A.Y.I.</au><au>Amer, Aziza M.</au><au>El-Aty, A.M. Abd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of three anthelmentics on disposition kinetics of florfenicol in goats</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>48</volume><issue>12</issue><spage>3340</spage><epage>3344</epage><pages>3340-3344</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>The pharmacokinetic aspects of florfenicol (FLO) were investigated via intravenous (I.V.) and intramuscular (I.M.) injections in five goats at a dose of 20
mg
kg
−1
b.wt. Animals were pre-treated with albendazole orally in a dose of 2.5
mg
kg
−1
b.wt, ivermectin or rafoxanide subcutaneously in a dose 0.2 and 7.5
mg
kg
−1
b.wt, respectively. Florfenicol was injected intramuscularly two hours following anthelmentic administration and blood samples were taken by jugular venapuncture at standardized intervals. The concentrations of florfenicol (FLO) in serum were determined by high performance liquid chromatography (HPLC) method. The obtained results revealed that ivermectin administration did not induce a significant difference in serum florfenicol concentration between anthelmentic-treated and non-treated goats. On the other hand, goats pre-treated with rafoxanide or albendazole showed a significant decrease in serum florfenicol level as compared to non-anthementic treated goats. The absorption half-life (
t
½ab),
C
max, AUMC, AUC and systemic bioavailability (F%) are significantly decreased, whereas elimination half-life (
t
½el) and MRT are increased in goats pre-treated by the three tested anthementics.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>20863870</pmid><doi>10.1016/j.fct.2010.08.039</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 2010-12, Vol.48 (12), p.3340-3344 |
| issn | 0278-6915 1873-6351 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_817607322 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Albendazole Albendazole - pharmacology Animals Anthelmintics - pharmacology Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Biological and medical sciences Chromatography, High Pressure Liquid Cross-Over Studies Drug Interactions Drug toxicity and drugs side effects treatment Female Florfenicol Goats - metabolism Half-Life Injections, Intramuscular Injections, Intravenous Interaction Ivermectin Ivermectin - pharmacology Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacokinetics Pharmacology. Drug treatments Rafoxanide Rafoxanide - pharmacology Reference Standards Thiamphenicol - administration & dosage Thiamphenicol - analogs & derivatives Thiamphenicol - pharmacokinetics |
| title | Effect of three anthelmentics on disposition kinetics of florfenicol in goats |
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