Blunted HPA axis responsiveness to stress in atopic patients is associated with the acuity and severeness of allergic inflammation
Research highlights ► Atopy is linked to reduced HPA axis responsiveness. ► In SAR patients reduced HPA axis reactivity is only evident during acute allergic inflammation. ► Atopy is linked to reduced hypothalamus-pitutitary-adrenal (HPA) axis responsiveness. ► Hyporesponsiveness of the HPA axis is...
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2010-11, Vol.24 (8), p.1347-1353 |
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| container_title | Brain, behavior, and immunity |
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| creator | Buske-Kirschbaum, A Ebrecht, M Hellhammer, D.H |
| description | Research highlights ► Atopy is linked to reduced HPA axis responsiveness. ► In SAR patients reduced HPA axis reactivity is only evident during acute allergic inflammation. ► Atopy is linked to reduced hypothalamus-pitutitary-adrenal (HPA) axis responsiveness. ► Hyporesponsiveness of the HPA axis is only evident during the acute allergic inflammatory state. |
| doi_str_mv | 10.1016/j.bbi.2010.06.013 |
| format | Article |
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Ebrecht, M ; Hellhammer, D.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-f6280dee26033f6d63fdb14a59f837f33c160f369502ee9ffea11aa9758073883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acuity</topic><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>Chronic (allergic) inflammation</topic><topic>Cortisol</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Hypersensitivity, Immediate - physiopathology</topic><topic>Hypothalamo-Hypophyseal System - physiopathology</topic><topic>Hypothalamus–pituitary–adrenal (HPA) axis</topic><topic>Immunoglobulin E - blood</topic><topic>Inflammation - physiopathology</topic><topic>Leukocyte Count</topic><topic>Leukocytes - immunology</topic><topic>Male</topic><topic>Pituitary-Adrenal System - physiopathology</topic><topic>Pollen - immunology</topic><topic>Psychiatry</topic><topic>Rhinitis, Allergic, Seasonal - physiopathology</topic><topic>Seasonal allergic rhinitis (SAR)</topic><topic>Social Environment</topic><topic>Stress</topic><topic>Stress, Psychological - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buske-Kirschbaum, A</creatorcontrib><creatorcontrib>Ebrecht, M</creatorcontrib><creatorcontrib>Hellhammer, D.H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Brain, behavior, and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buske-Kirschbaum, A</au><au>Ebrecht, M</au><au>Hellhammer, D.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blunted HPA axis responsiveness to stress in atopic patients is associated with the acuity and severeness of allergic inflammation</atitle><jtitle>Brain, behavior, and immunity</jtitle><addtitle>Brain Behav Immun</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>24</volume><issue>8</issue><spage>1347</spage><epage>1353</epage><pages>1347-1353</pages><issn>0889-1591</issn><eissn>1090-2139</eissn><abstract>Research highlights ► Atopy is linked to reduced HPA axis responsiveness. ► In SAR patients reduced HPA axis reactivity is only evident during acute allergic inflammation. ► Atopy is linked to reduced hypothalamus-pitutitary-adrenal (HPA) axis responsiveness. ► Hyporesponsiveness of the HPA axis is only evident during the acute allergic inflammatory state.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>20633637</pmid><doi>10.1016/j.bbi.2010.06.013</doi><tpages>7</tpages></addata></record> |
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| ispartof | Brain, behavior, and immunity, 2010-11, Vol.24 (8), p.1347-1353 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Acuity Adult Allergy and Immunology Chronic (allergic) inflammation Cortisol Female Humans Hydrocortisone - blood Hypersensitivity, Immediate - physiopathology Hypothalamo-Hypophyseal System - physiopathology Hypothalamus–pituitary–adrenal (HPA) axis Immunoglobulin E - blood Inflammation - physiopathology Leukocyte Count Leukocytes - immunology Male Pituitary-Adrenal System - physiopathology Pollen - immunology Psychiatry Rhinitis, Allergic, Seasonal - physiopathology Seasonal allergic rhinitis (SAR) Social Environment Stress Stress, Psychological - physiopathology |
| title | Blunted HPA axis responsiveness to stress in atopic patients is associated with the acuity and severeness of allergic inflammation |
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