Blunted HPA axis responsiveness to stress in atopic patients is associated with the acuity and severeness of allergic inflammation

Blunted HPA axis responsiveness to stress in atopic patients is associated with the acuity and severeness of allergic inflammation

Research highlights ► Atopy is linked to reduced HPA axis responsiveness. ► In SAR patients reduced HPA axis reactivity is only evident during acute allergic inflammation. ► Atopy is linked to reduced hypothalamus-pitutitary-adrenal (HPA) axis responsiveness. ► Hyporesponsiveness of the HPA axis is...

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Veröffentlicht in:Brain, behavior, and immunity behavior, and immunity, 2010-11, Vol.24 (8), p.1347-1353
Hauptverfasser: Buske-Kirschbaum, A, Ebrecht, M, Hellhammer, D.H
Format: Artikel
Sprache:eng
Schlagworte:
Acuity
Adult
Allergy and Immunology
Chronic (allergic) inflammation
Cortisol
Female
Humans
Hydrocortisone - blood
Hypersensitivity, Immediate - physiopathology
Hypothalamo-Hypophyseal System - physiopathology
Hypothalamus–pituitary–adrenal (HPA) axis
Immunoglobulin E - blood
Inflammation - physiopathology
Leukocyte Count
Leukocytes - immunology
Male
Pituitary-Adrenal System - physiopathology
Pollen - immunology
Psychiatry
Rhinitis, Allergic, Seasonal - physiopathology
Seasonal allergic rhinitis (SAR)
Social Environment
Stress
Stress, Psychological - physiopathology
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Zusammenfassung:Research highlights ► Atopy is linked to reduced HPA axis responsiveness. ► In SAR patients reduced HPA axis reactivity is only evident during acute allergic inflammation. ► Atopy is linked to reduced hypothalamus-pitutitary-adrenal (HPA) axis responsiveness. ► Hyporesponsiveness of the HPA axis is only evident during the acute allergic inflammatory state.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2010.06.013