Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia : a case-control study

We genotyped six folate metabolic pathway genes for 11 polymorphisms in 460 cases of childhood acute lymphoblastic leukemia (ALL) and 552 ethnically matched controls. None of the polymorphisms except the 66A>G (I22M) in the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR)...

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Veröffentlicht in:	Leukemia 2007-02, Vol.21 (2), p.320-325
Hauptverfasser:	GAST, A, BERMEJO, J. L, FLOHR, T, STANULLA, M, BURWINKEL, B, SCHRAPPE, M, BARTRAM, C. R, HEMMINKI, K, KUMAR, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Acute lymphocytic leukemia Adolescent Adult Base Sequence Biological and medical sciences Cancer research Care and treatment Case-Control Studies Child Child, Preschool Childhood Children Confidence intervals DNA, Neoplasm - genetics Enzymes Epidemiology Female Folic acid Folic Acid - genetics Folic Acid - metabolism Gene polymorphism Genes Genetic aspects Genetic polymorphisms Genetic testing Genotype Genotype & phenotype Haplotypes Health aspects Health risks Hematologic and hematopoietic diseases Homocysteine Humans Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Male Medical research Medical sciences Metabolic pathways Metabolism Methyltransferase Morphology MtrR gene Odds Ratio Polymorphism Polymorphism, Genetic Polymorphism, Single Nucleotide Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Reductases Reference Values Risk analysis Risk management Statistical analysis Vitamin B
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