Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal drug sequestration

Multidrug resistance (MDR) seriously limits the efficacy of chemotherapy in patients with cancer and leukemia. Active transport across membranes is essential for such cellular drug resistance, largely provided by ATP-binding cassette (ABC) transport proteins. Intracellular drug sequestration contrib...

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Veröffentlicht in:	Leukemia 2008-08, Vol.22 (8), p.1576-1586
Hauptverfasser:	Chapuy, B, Koch, R, Radunski, U, Corsham, S, Cheong, N, Inagaki, N, Ban, N, Wenzel, D, Reinhardt, D, Zapf, A, Schweyer, S, Kosari, F, Klapper, W, Truemper, L, Wulf, G G
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporter ABC transporters Active transport Acute Disease Acute myeloid leukemia Antibodies ATP-Binding Cassette Transporters - physiology Base Sequence Biological and medical sciences Bone marrow Cancer Cancer Research Cell Line, Tumor Chemotherapy Complications and side effects Critical Care Medicine Cytostatic agents Disease DNA Primers Drug resistance Drug Resistance, Multiple Drug Resistance, Neoplasm Drug therapy Efflux Flow Cytometry Hematologic and hematopoietic diseases Hematology Humans Influence Intensive Internal Medicine Intracellular Leukemia Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma Lysosomes Lysosomes - metabolism Medical sciences Medicine Medicine & Public Health Membranes Multidrug resistance Multidrug resistant organisms Neurosciences Oncology original-article Physiology Plasmids Polymerase Chain Reaction Prognosis Protein transport Proteins Risk factors Stem cells
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