Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells: Stem Cells

Tumors contain a fraction of cancer stem cells that maintain the propagation of the disease. The CD34+CD38− cells, isolated from acute myeloid leukemia (AML), were shown to be enriched leukemic stem cells (LSC). We isolated the CD34+CD38− cell fraction from AML and compared their gene expression pro...

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Veröffentlicht in:	Leukemia 2006-12, Vol.20 (12), p.2147-2154
Hauptverfasser:	Gal, H, Amariglio, N, Trakhtenbrot, L, Jacob-Hirsh, J, Margalit, O, Avigdor, A, Nagler, A, Tavor, S, Ein-Dor, L, Lapidot, T, Domany, E, Rechavi, G, Givol, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Biological and medical sciences Biology Cancer Cancer Research CD34 antigen CD38 antigen Cell cycle Cell Cycle - genetics Cell self-renewal Chromosome aberrations Critical Care Medicine DNA microarrays DNA repair DNA Repair - genetics Female gamma-Aminobutyric Acid - analogs & derivatives gamma-Aminobutyric Acid - pharmacology Gene expression Gene Expression Profiling Genes Hematologic and hematopoietic diseases Hematology Hematopoietic stem cells Hematopoietic Stem Cells - metabolism Humans Intensive Internal Medicine Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical prognosis Medical sciences Medicine Medicine & Public Health Mutation Neoplastic Stem Cells - metabolism Oncology original-article Progenitor cells Proteinase inhibitors Receptors, Notch - antagonists & inhibitors Receptors, Notch - physiology Secretase Signal Transduction Stem cells Triglycerides - pharmacology Tumors
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