The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis
Proper response of normal stem cells (NSC) to motomorphogens and chemoattractants plays a pivotal role in organ development and renewal/regeneration of damaged tissues. Similar chemoattractants may also regulate metastasis of cancer stem cells (CSC). Growing experimental evidence indicates that both...
Gespeichert in:
| Veröffentlicht in: | Leukemia 2006-11, Vol.20 (11), p.1915-1924 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1924 |
|---|---|
| container_issue | 11 |
| container_start_page | 1915 |
| container_title | Leukemia |
| container_volume | 20 |
| creator | Ratajczak, M Z Zuba-Surma, E Kucia, M Reca, R Wojakowski, W Ratajczak, J |
| description | Proper response of normal stem cells (NSC) to motomorphogens and chemoattractants plays a pivotal role in organ development and renewal/regeneration of damaged tissues. Similar chemoattractants may also regulate metastasis of cancer stem cells (CSC). Growing experimental evidence indicates that both NSC and CSC express G-protein-coupled seven-transmembrane span receptor CXCR4 and respond to its specific ligand
α
-chemokine stromal derived factor-1 (SDF-1), which is expressed by stroma cells from different tissues. In addition, a population of very small embryonic-like (VSEL) stem cells that express CXCR4 and respond robustly to an SDF-1 gradient was recently identified in adult tissues. VSELs express several markers of embryonic and primordial germ cells. It is proposed that these cells are deposited early in the development as a dormant pool of embryonic/pluripotent NSC. Expression of both CXCR4 and SDF-1 is upregulated in response to tissue hypoxia and damage signal attracting circulating NSC and CSC. Thus, pharmacological modulation of the SDF-1–CXCR4 axis may lead to the development of new therapeutic strategies to enhance mobilization of CXCR4
+
NSC and their homing to damaged organs as well as inhibition of the metastasis of CXCR4
+
cancer cells. |
| doi_str_mv | 10.1038/sj.leu.2404357 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_817602970</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A188530970</galeid><sourcerecordid>A188530970</sourcerecordid><originalsourceid>FETCH-LOGICAL-c648t-2bc366523b1a6dc6419bbaf7b6a6016e0a6988477a4b17291baa040fa4d3b24c3</originalsourceid><addsrcrecordid>eNp9kl2L1DAUhoso7rh6651SFPXGziZpmo_LZXRVWBB0Be_qaXo6k6GTjEkLu__e1KkOK6zkIuG8z_kKb5Y9pWRJSanO4nbZ47hknPCykveyBeVSFFVV0fvZgiglC6EZP8kexbglZBLFw-yECk0II3qR_bjaYL7v0foh-L01OXYdmiHmvsuHJH19d1HQYvV99YXncG1jbl3uwxqcX6PDaOPbPOD0DDBY73JwbT6MOx_srD_OHnTQR3wy36fZt4v3V6uPxeXnD59W55eFEVwNBWtMKUTFyoaCaFOM6qaBTjYCBKECCQitFJcSeEMl07QBIJx0wNuyYdyUp9mbQ9198D9HjEO9s9Fg34NDP8ZaUSkI05Ik8vV_SaG0klzrBL78B9z6Mbi0Rc0ErySRQotEvbiTYqTirFQyQcsDtIYea-u69N1g0mlxZ4132NkUP6dKVSW5NeTvhA1CP2yi78fpk-NtcK5sgo8xYFfvg91BuKkpqSeL1HFbJ4vUs0VSwvN53rHZYXvEZ08k4NUMQDTQdwGcsfHIKcYrQabOZwcuJsmtMRwXv7P1s0OGg2EM-LfkH_0XZf7avQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220542387</pqid></control><display><type>article</type><title>The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis</title><source>MEDLINE</source><source>Nature</source><source>EZB-FREE-00999 freely available EZB journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Ratajczak, M Z ; Zuba-Surma, E ; Kucia, M ; Reca, R ; Wojakowski, W ; Ratajczak, J</creator><creatorcontrib>Ratajczak, M Z ; Zuba-Surma, E ; Kucia, M ; Reca, R ; Wojakowski, W ; Ratajczak, J</creatorcontrib><description>Proper response of normal stem cells (NSC) to motomorphogens and chemoattractants plays a pivotal role in organ development and renewal/regeneration of damaged tissues. Similar chemoattractants may also regulate metastasis of cancer stem cells (CSC). Growing experimental evidence indicates that both NSC and CSC express G-protein-coupled seven-transmembrane span receptor CXCR4 and respond to its specific ligand
α
-chemokine stromal derived factor-1 (SDF-1), which is expressed by stroma cells from different tissues. In addition, a population of very small embryonic-like (VSEL) stem cells that express CXCR4 and respond robustly to an SDF-1 gradient was recently identified in adult tissues. VSELs express several markers of embryonic and primordial germ cells. It is proposed that these cells are deposited early in the development as a dormant pool of embryonic/pluripotent NSC. Expression of both CXCR4 and SDF-1 is upregulated in response to tissue hypoxia and damage signal attracting circulating NSC and CSC. Thus, pharmacological modulation of the SDF-1–CXCR4 axis may lead to the development of new therapeutic strategies to enhance mobilization of CXCR4
+
NSC and their homing to damaged organs as well as inhibition of the metastasis of CXCR4
+
cancer cells.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/sj.leu.2404357</identifier><identifier>PMID: 16900209</identifier><identifier>CODEN: LEUKED</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Biological and medical sciences ; Cancer ; Cancer Research ; Chemokine CXCL12 ; Chemokines ; Chemokines, CXC - physiology ; Chemotactic factors ; Critical Care Medicine ; CXCR4 protein ; Cytokines ; Damage ; Embryo cells ; Embryogenesis ; Germ cells ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; Hypoxia ; Intensive ; Internal Medicine ; Leukemia ; Ligands ; Liver ; Medical sciences ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Mutation ; Neoplasms - physiopathology ; Oncology ; Organogenesis ; Organogenesis - physiology ; Organs ; Pluripotency ; Proteins ; Receptors, CXCR4 - physiology ; Regeneration ; Regeneration - physiology ; SDF-1 protein ; spotlight-review ; Stem cells ; Stroma ; Tissues ; Tumorigenesis</subject><ispartof>Leukemia, 2006-11, Vol.20 (11), p.1915-1924</ispartof><rights>Springer Nature Limited 2006</rights><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 2006</rights><rights>Nature Publishing Group 2006.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c648t-2bc366523b1a6dc6419bbaf7b6a6016e0a6988477a4b17291baa040fa4d3b24c3</citedby><cites>FETCH-LOGICAL-c648t-2bc366523b1a6dc6419bbaf7b6a6016e0a6988477a4b17291baa040fa4d3b24c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.leu.2404357$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.leu.2404357$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18245600$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16900209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ratajczak, M Z</creatorcontrib><creatorcontrib>Zuba-Surma, E</creatorcontrib><creatorcontrib>Kucia, M</creatorcontrib><creatorcontrib>Reca, R</creatorcontrib><creatorcontrib>Wojakowski, W</creatorcontrib><creatorcontrib>Ratajczak, J</creatorcontrib><title>The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><description>Proper response of normal stem cells (NSC) to motomorphogens and chemoattractants plays a pivotal role in organ development and renewal/regeneration of damaged tissues. Similar chemoattractants may also regulate metastasis of cancer stem cells (CSC). Growing experimental evidence indicates that both NSC and CSC express G-protein-coupled seven-transmembrane span receptor CXCR4 and respond to its specific ligand
α
-chemokine stromal derived factor-1 (SDF-1), which is expressed by stroma cells from different tissues. In addition, a population of very small embryonic-like (VSEL) stem cells that express CXCR4 and respond robustly to an SDF-1 gradient was recently identified in adult tissues. VSELs express several markers of embryonic and primordial germ cells. It is proposed that these cells are deposited early in the development as a dormant pool of embryonic/pluripotent NSC. Expression of both CXCR4 and SDF-1 is upregulated in response to tissue hypoxia and damage signal attracting circulating NSC and CSC. Thus, pharmacological modulation of the SDF-1–CXCR4 axis may lead to the development of new therapeutic strategies to enhance mobilization of CXCR4
+
NSC and their homing to damaged organs as well as inhibition of the metastasis of CXCR4
+
cancer cells.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Chemokine CXCL12</subject><subject>Chemokines</subject><subject>Chemokines, CXC - physiology</subject><subject>Chemotactic factors</subject><subject>Critical Care Medicine</subject><subject>CXCR4 protein</subject><subject>Cytokines</subject><subject>Damage</subject><subject>Embryo cells</subject><subject>Embryogenesis</subject><subject>Germ cells</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Ligands</subject><subject>Liver</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Mutation</subject><subject>Neoplasms - physiopathology</subject><subject>Oncology</subject><subject>Organogenesis</subject><subject>Organogenesis - physiology</subject><subject>Organs</subject><subject>Pluripotency</subject><subject>Proteins</subject><subject>Receptors, CXCR4 - physiology</subject><subject>Regeneration</subject><subject>Regeneration - physiology</subject><subject>SDF-1 protein</subject><subject>spotlight-review</subject><subject>Stem cells</subject><subject>Stroma</subject><subject>Tissues</subject><subject>Tumorigenesis</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kl2L1DAUhoso7rh6651SFPXGziZpmo_LZXRVWBB0Be_qaXo6k6GTjEkLu__e1KkOK6zkIuG8z_kKb5Y9pWRJSanO4nbZ47hknPCykveyBeVSFFVV0fvZgiglC6EZP8kexbglZBLFw-yECk0II3qR_bjaYL7v0foh-L01OXYdmiHmvsuHJH19d1HQYvV99YXncG1jbl3uwxqcX6PDaOPbPOD0DDBY73JwbT6MOx_srD_OHnTQR3wy36fZt4v3V6uPxeXnD59W55eFEVwNBWtMKUTFyoaCaFOM6qaBTjYCBKECCQitFJcSeEMl07QBIJx0wNuyYdyUp9mbQ9198D9HjEO9s9Fg34NDP8ZaUSkI05Ik8vV_SaG0klzrBL78B9z6Mbi0Rc0ErySRQotEvbiTYqTirFQyQcsDtIYea-u69N1g0mlxZ4132NkUP6dKVSW5NeTvhA1CP2yi78fpk-NtcK5sgo8xYFfvg91BuKkpqSeL1HFbJ4vUs0VSwvN53rHZYXvEZ08k4NUMQDTQdwGcsfHIKcYrQabOZwcuJsmtMRwXv7P1s0OGg2EM-LfkH_0XZf7avQ</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>Ratajczak, M Z</creator><creator>Zuba-Surma, E</creator><creator>Kucia, M</creator><creator>Reca, R</creator><creator>Wojakowski, W</creator><creator>Ratajczak, J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20061101</creationdate><title>The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis</title><author>Ratajczak, M Z ; Zuba-Surma, E ; Kucia, M ; Reca, R ; Wojakowski, W ; Ratajczak, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c648t-2bc366523b1a6dc6419bbaf7b6a6016e0a6988477a4b17291baa040fa4d3b24c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Chemokine CXCL12</topic><topic>Chemokines</topic><topic>Chemokines, CXC - physiology</topic><topic>Chemotactic factors</topic><topic>Critical Care Medicine</topic><topic>CXCR4 protein</topic><topic>Cytokines</topic><topic>Damage</topic><topic>Embryo cells</topic><topic>Embryogenesis</topic><topic>Germ cells</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Intensive</topic><topic>Internal Medicine</topic><topic>Leukemia</topic><topic>Ligands</topic><topic>Liver</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Mutation</topic><topic>Neoplasms - physiopathology</topic><topic>Oncology</topic><topic>Organogenesis</topic><topic>Organogenesis - physiology</topic><topic>Organs</topic><topic>Pluripotency</topic><topic>Proteins</topic><topic>Receptors, CXCR4 - physiology</topic><topic>Regeneration</topic><topic>Regeneration - physiology</topic><topic>SDF-1 protein</topic><topic>spotlight-review</topic><topic>Stem cells</topic><topic>Stroma</topic><topic>Tissues</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ratajczak, M Z</creatorcontrib><creatorcontrib>Zuba-Surma, E</creatorcontrib><creatorcontrib>Kucia, M</creatorcontrib><creatorcontrib>Reca, R</creatorcontrib><creatorcontrib>Wojakowski, W</creatorcontrib><creatorcontrib>Ratajczak, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ratajczak, M Z</au><au>Zuba-Surma, E</au><au>Kucia, M</au><au>Reca, R</au><au>Wojakowski, W</au><au>Ratajczak, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis</atitle><jtitle>Leukemia</jtitle><stitle>Leukemia</stitle><addtitle>Leukemia</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>20</volume><issue>11</issue><spage>1915</spage><epage>1924</epage><pages>1915-1924</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><coden>LEUKED</coden><abstract>Proper response of normal stem cells (NSC) to motomorphogens and chemoattractants plays a pivotal role in organ development and renewal/regeneration of damaged tissues. Similar chemoattractants may also regulate metastasis of cancer stem cells (CSC). Growing experimental evidence indicates that both NSC and CSC express G-protein-coupled seven-transmembrane span receptor CXCR4 and respond to its specific ligand
α
-chemokine stromal derived factor-1 (SDF-1), which is expressed by stroma cells from different tissues. In addition, a population of very small embryonic-like (VSEL) stem cells that express CXCR4 and respond robustly to an SDF-1 gradient was recently identified in adult tissues. VSELs express several markers of embryonic and primordial germ cells. It is proposed that these cells are deposited early in the development as a dormant pool of embryonic/pluripotent NSC. Expression of both CXCR4 and SDF-1 is upregulated in response to tissue hypoxia and damage signal attracting circulating NSC and CSC. Thus, pharmacological modulation of the SDF-1–CXCR4 axis may lead to the development of new therapeutic strategies to enhance mobilization of CXCR4
+
NSC and their homing to damaged organs as well as inhibition of the metastasis of CXCR4
+
cancer cells.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16900209</pmid><doi>10.1038/sj.leu.2404357</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0887-6924 |
| ispartof | Leukemia, 2006-11, Vol.20 (11), p.1915-1924 |
| issn | 0887-6924 1476-5551 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_817602970 |
| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biological and medical sciences Cancer Cancer Research Chemokine CXCL12 Chemokines Chemokines, CXC - physiology Chemotactic factors Critical Care Medicine CXCR4 protein Cytokines Damage Embryo cells Embryogenesis Germ cells Hematologic and hematopoietic diseases Hematology Humans Hypoxia Intensive Internal Medicine Leukemia Ligands Liver Medical sciences Medicine Medicine & Public Health Metastases Metastasis Mutation Neoplasms - physiopathology Oncology Organogenesis Organogenesis - physiology Organs Pluripotency Proteins Receptors, CXCR4 - physiology Regeneration Regeneration - physiology SDF-1 protein spotlight-review Stem cells Stroma Tissues Tumorigenesis |
| title | The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T03%3A47%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20pleiotropic%20effects%20of%20the%20SDF-1-CXCR4%20axis%20in%20organogenesis,%20regeneration%20and%20tumorigenesis&rft.jtitle=Leukemia&rft.au=Ratajczak,%20M%20Z&rft.date=2006-11-01&rft.volume=20&rft.issue=11&rft.spage=1915&rft.epage=1924&rft.pages=1915-1924&rft.issn=0887-6924&rft.eissn=1476-5551&rft.coden=LEUKED&rft_id=info:doi/10.1038/sj.leu.2404357&rft_dat=%3Cgale_proqu%3EA188530970%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=220542387&rft_id=info:pmid/16900209&rft_galeid=A188530970&rfr_iscdi=true |