Novel FISH probes designed to detect IGK-MYC and IGL-MYC rearrangements in b-cell lineage malignancy identify a new breakpoint cluster region designated BVR2
Detection of translocations involving MYC at 8q24.1 in B-cell lineage malignancies (BCL) is important for diagnostic and prognostic purposes. However, routine detection of MYC translocations is often hampered by the wide variation in breakpoint location within the MYC region, particularly when a gen...
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| Veröffentlicht in: | Leukemia 2006-10, Vol.20 (10), p.1790-1799 |
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| creator | EINERSON, R. R LAW, M. E BLAIR, H. E KURTIN, P. J MCCLURE, R. F KETTERLING, R. P FLYNN, H. C DOGAN, A REMSTEIN, E. D |
| description | Detection of translocations involving MYC at 8q24.1 in B-cell lineage malignancies (BCL) is important for diagnostic and prognostic purposes. However, routine detection of MYC translocations is often hampered by the wide variation in breakpoint location within the MYC region, particularly when a gene other than IGH, such as IGK or IGL, is involved. To address this issue, we developed and validated four fluorescence in situ hybridization (FISH) probes: two break apart probes to detect IGK and IGL translocations, and two dual-color, dual-fusion FISH (D-FISH) probes to detect IGK-MYC and IGL-MYC. MYC rearrangements (four IGK-MYC, 12 IGL-MYC and four unknown partner gene-MYC) were correctly identified in 20 of 20 archival BCL specimens known to have MYC rearrangements not involving IGH. Seven specimens, all of which lacked MYC rearrangements using a commercial IGH/MYC D-FISH probe, were found to have 8q24 breakpoints within a cluster region >350-645 kb 3' from MYC, provisionally designated as Burkitt variant rearrangement region 2 (BVR2). FISH is a useful ancillary tool in identifying MYC rearrangements. In light of the discovery of the distally located BVR2 breakpoint cluster region, it is important to use MYC FISH probes that cover a breakpoint region at least 1.0 Mb 3' of MYC. |
| doi_str_mv | 10.1038/sj.leu.2404340 |
| format | Article |
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R ; LAW, M. E ; BLAIR, H. E ; KURTIN, P. J ; MCCLURE, R. F ; KETTERLING, R. P ; FLYNN, H. C ; DOGAN, A ; REMSTEIN, E. D</creator><creatorcontrib>EINERSON, R. R ; LAW, M. E ; BLAIR, H. E ; KURTIN, P. J ; MCCLURE, R. F ; KETTERLING, R. P ; FLYNN, H. C ; DOGAN, A ; REMSTEIN, E. D</creatorcontrib><description>Detection of translocations involving MYC at 8q24.1 in B-cell lineage malignancies (BCL) is important for diagnostic and prognostic purposes. However, routine detection of MYC translocations is often hampered by the wide variation in breakpoint location within the MYC region, particularly when a gene other than IGH, such as IGK or IGL, is involved. To address this issue, we developed and validated four fluorescence in situ hybridization (FISH) probes: two break apart probes to detect IGK and IGL translocations, and two dual-color, dual-fusion FISH (D-FISH) probes to detect IGK-MYC and IGL-MYC. MYC rearrangements (four IGK-MYC, 12 IGL-MYC and four unknown partner gene-MYC) were correctly identified in 20 of 20 archival BCL specimens known to have MYC rearrangements not involving IGH. Seven specimens, all of which lacked MYC rearrangements using a commercial IGH/MYC D-FISH probe, were found to have 8q24 breakpoints within a cluster region >350-645 kb 3' from MYC, provisionally designated as Burkitt variant rearrangement region 2 (BVR2). FISH is a useful ancillary tool in identifying MYC rearrangements. 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Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphocytes B ; Lymphoma ; Lymphoma, B-Cell - diagnosis ; Lymphoma, B-Cell - genetics ; Malignancy ; Medical prognosis ; Medical sciences ; Myc protein ; Pathology ; Probes ; Translocation ; Translocation, Genetic - genetics</subject><ispartof>Leukemia, 2006-10, Vol.20 (10), p.1790-1799</ispartof><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Oct 2006</rights><rights>Nature Publishing Group 2006.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c617t-1cb271904af832b0903403e2f25bcc500302b6bc91645d217025ad33474cd0253</citedby><cites>FETCH-LOGICAL-c617t-1cb271904af832b0903403e2f25bcc500302b6bc91645d217025ad33474cd0253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18155375$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16888615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EINERSON, R. R</creatorcontrib><creatorcontrib>LAW, M. E</creatorcontrib><creatorcontrib>BLAIR, H. E</creatorcontrib><creatorcontrib>KURTIN, P. J</creatorcontrib><creatorcontrib>MCCLURE, R. F</creatorcontrib><creatorcontrib>KETTERLING, R. P</creatorcontrib><creatorcontrib>FLYNN, H. C</creatorcontrib><creatorcontrib>DOGAN, A</creatorcontrib><creatorcontrib>REMSTEIN, E. D</creatorcontrib><title>Novel FISH probes designed to detect IGK-MYC and IGL-MYC rearrangements in b-cell lineage malignancy identify a new breakpoint cluster region designated BVR2</title><title>Leukemia</title><addtitle>Leukemia</addtitle><description>Detection of translocations involving MYC at 8q24.1 in B-cell lineage malignancies (BCL) is important for diagnostic and prognostic purposes. However, routine detection of MYC translocations is often hampered by the wide variation in breakpoint location within the MYC region, particularly when a gene other than IGH, such as IGK or IGL, is involved. To address this issue, we developed and validated four fluorescence in situ hybridization (FISH) probes: two break apart probes to detect IGK and IGL translocations, and two dual-color, dual-fusion FISH (D-FISH) probes to detect IGK-MYC and IGL-MYC. MYC rearrangements (four IGK-MYC, 12 IGL-MYC and four unknown partner gene-MYC) were correctly identified in 20 of 20 archival BCL specimens known to have MYC rearrangements not involving IGH. Seven specimens, all of which lacked MYC rearrangements using a commercial IGH/MYC D-FISH probe, were found to have 8q24 breakpoints within a cluster region >350-645 kb 3' from MYC, provisionally designated as Burkitt variant rearrangement region 2 (BVR2). FISH is a useful ancillary tool in identifying MYC rearrangements. In light of the discovery of the distally located BVR2 breakpoint cluster region, it is important to use MYC FISH probes that cover a breakpoint region at least 1.0 Mb 3' of MYC.</description><subject>B-Lymphocytes - physiology</subject><subject>Biological and medical sciences</subject><subject>Breakpoints</subject><subject>Cell lineage</subject><subject>Chromosomes, Artificial, Bacterial - genetics</subject><subject>Cloning</subject><subject>Clusters</subject><subject>Cytogenetics</subject><subject>DNA Probes - genetics</subject><subject>Fluorescence</subject><subject>Fluorescence in situ hybridization</subject><subject>Gene loci</subject><subject>Gene Rearrangement, B-Lymphocyte - genetics</subject><subject>Genes, myc - genetics</subject><subject>Genetic Testing - methods</subject><subject>Heavy chains</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Hybridization</subject><subject>Immunoglobulin Light Chains - genetics</subject><subject>Immunoglobulins</subject><subject>Immunoglobulins - genetics</subject><subject>In Situ Hybridization, Fluorescence - methods</subject><subject>Leukemia</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. 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R ; LAW, M. E ; BLAIR, H. E ; KURTIN, P. J ; MCCLURE, R. F ; KETTERLING, R. P ; FLYNN, H. C ; DOGAN, A ; REMSTEIN, E. 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Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphocytes B</topic><topic>Lymphoma</topic><topic>Lymphoma, B-Cell - diagnosis</topic><topic>Lymphoma, B-Cell - genetics</topic><topic>Malignancy</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Myc protein</topic><topic>Pathology</topic><topic>Probes</topic><topic>Translocation</topic><topic>Translocation, Genetic - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EINERSON, R. R</creatorcontrib><creatorcontrib>LAW, M. E</creatorcontrib><creatorcontrib>BLAIR, H. E</creatorcontrib><creatorcontrib>KURTIN, P. J</creatorcontrib><creatorcontrib>MCCLURE, R. F</creatorcontrib><creatorcontrib>KETTERLING, R. P</creatorcontrib><creatorcontrib>FLYNN, H. C</creatorcontrib><creatorcontrib>DOGAN, A</creatorcontrib><creatorcontrib>REMSTEIN, E. 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R</au><au>LAW, M. E</au><au>BLAIR, H. E</au><au>KURTIN, P. J</au><au>MCCLURE, R. F</au><au>KETTERLING, R. P</au><au>FLYNN, H. C</au><au>DOGAN, A</au><au>REMSTEIN, E. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel FISH probes designed to detect IGK-MYC and IGL-MYC rearrangements in b-cell lineage malignancy identify a new breakpoint cluster region designated BVR2</atitle><jtitle>Leukemia</jtitle><addtitle>Leukemia</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>20</volume><issue>10</issue><spage>1790</spage><epage>1799</epage><pages>1790-1799</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><coden>LEUKED</coden><abstract>Detection of translocations involving MYC at 8q24.1 in B-cell lineage malignancies (BCL) is important for diagnostic and prognostic purposes. However, routine detection of MYC translocations is often hampered by the wide variation in breakpoint location within the MYC region, particularly when a gene other than IGH, such as IGK or IGL, is involved. To address this issue, we developed and validated four fluorescence in situ hybridization (FISH) probes: two break apart probes to detect IGK and IGL translocations, and two dual-color, dual-fusion FISH (D-FISH) probes to detect IGK-MYC and IGL-MYC. MYC rearrangements (four IGK-MYC, 12 IGL-MYC and four unknown partner gene-MYC) were correctly identified in 20 of 20 archival BCL specimens known to have MYC rearrangements not involving IGH. Seven specimens, all of which lacked MYC rearrangements using a commercial IGH/MYC D-FISH probe, were found to have 8q24 breakpoints within a cluster region >350-645 kb 3' from MYC, provisionally designated as Burkitt variant rearrangement region 2 (BVR2). FISH is a useful ancillary tool in identifying MYC rearrangements. In light of the discovery of the distally located BVR2 breakpoint cluster region, it is important to use MYC FISH probes that cover a breakpoint region at least 1.0 Mb 3' of MYC.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>16888615</pmid><doi>10.1038/sj.leu.2404340</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Leukemia, 2006-10, Vol.20 (10), p.1790-1799 |
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| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | B-Lymphocytes - physiology Biological and medical sciences Breakpoints Cell lineage Chromosomes, Artificial, Bacterial - genetics Cloning Clusters Cytogenetics DNA Probes - genetics Fluorescence Fluorescence in situ hybridization Gene loci Gene Rearrangement, B-Lymphocyte - genetics Genes, myc - genetics Genetic Testing - methods Heavy chains Hematologic and hematopoietic diseases Humans Hybridization Immunoglobulin Light Chains - genetics Immunoglobulins Immunoglobulins - genetics In Situ Hybridization, Fluorescence - methods Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes B Lymphoma Lymphoma, B-Cell - diagnosis Lymphoma, B-Cell - genetics Malignancy Medical prognosis Medical sciences Myc protein Pathology Probes Translocation Translocation, Genetic - genetics |
| title | Novel FISH probes designed to detect IGK-MYC and IGL-MYC rearrangements in b-cell lineage malignancy identify a new breakpoint cluster region designated BVR2 |
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