Agglutinin isolated from the red marine alga Hypnea cervicornis J. Agardh reduces inflammatory hypernociception: Involvement of nitric oxide
Hypnea cervicornis agglutinin (HCA), a lectin isolated from the red marine alga has been previously shown to have an antinociceptive effect. In the present study in rats, mechanisms of action of HCA were addressed regarding mechanical hypernociception induced by carrageenan, ovalbumin (as antigen),...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2010-10, Vol.96 (4), p.371-377 |
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| creator | Figueiredo, Jozi G. Bitencourt, Flavio S. Cunha, Thiago M. Luz, Patrícia B. Nascimento, Kyria S. Mota, Mario R.L. Sampaio, Alexandre H. Cavada, Benildo S. Cunha, Fernando Q. Alencar, Nylane M.N. |
| description | Hypnea cervicornis agglutinin (HCA), a lectin isolated from the red marine alga has been previously shown to have an antinociceptive effect. In the present study in rats, mechanisms of action of HCA were addressed regarding mechanical hypernociception induced by carrageenan, ovalbumin (as antigen), and also by prostaglandin E
2 in rats. The lectin administered intravenously inhibited carrageenan- and antigen-induced hypernociception at 1, 3, 5 and 7
h. This inhibitory effect was completely prevented when lectin was combined with mucin, demonstrating the role of carbohydrate-binding sites. The inhibition of inflammatory hypernociception by HCA was associated with the prevention of neutrophil recruitment to the plantar tissue of rats but was not associated with the inhibition of the release of pro-hypernociceptive cytokines (TNF-α, IL-1β and CINC-1). HCA also blocked mechanical hypernociception induced by PGE
2, which was prevented by the administration of nitric oxide synthase inhibitors. These results were corroborated by the increased circulating levels of NO metabolites following HCA treatment. These findings suggest that the anti-hypernociceptive effects of HCA are not associated with the inhibition of pro-inflammatory cytokine production. However, these effects seem to involve the inhibition of neutrophil migration and also the increase in NO production. |
| doi_str_mv | 10.1016/j.pbb.2010.06.008 |
| format | Article |
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2 in rats. The lectin administered intravenously inhibited carrageenan- and antigen-induced hypernociception at 1, 3, 5 and 7
h. This inhibitory effect was completely prevented when lectin was combined with mucin, demonstrating the role of carbohydrate-binding sites. The inhibition of inflammatory hypernociception by HCA was associated with the prevention of neutrophil recruitment to the plantar tissue of rats but was not associated with the inhibition of the release of pro-hypernociceptive cytokines (TNF-α, IL-1β and CINC-1). HCA also blocked mechanical hypernociception induced by PGE
2, which was prevented by the administration of nitric oxide synthase inhibitors. These results were corroborated by the increased circulating levels of NO metabolites following HCA treatment. These findings suggest that the anti-hypernociceptive effects of HCA are not associated with the inhibition of pro-inflammatory cytokine production. However, these effects seem to involve the inhibition of neutrophil migration and also the increase in NO production.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/j.pbb.2010.06.008</identifier><identifier>PMID: 20600247</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>Kidlington: Elsevier Inc</publisher><subject>Agglutinins ; Agglutinins - isolation & purification ; Agglutinins - pharmacology ; Animals ; Biological and medical sciences ; Cytokines - biosynthesis ; Hyperalgesia - prevention & control ; Hypernociception ; Hypnea cervicornis ; Inflammation ; Inflammation - prevention & control ; Lectin ; Medical sciences ; Nitric oxide ; Nitric Oxide - physiology ; Peroxidase - metabolism ; Rats ; Rats, Wistar ; Rhodophyta - chemistry</subject><ispartof>Pharmacology, biochemistry and behavior, 2010-10, Vol.96 (4), p.371-377</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>(c) 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-827ba6f2ebb2cba71b4f3f1d48bf821aae81a6147818b7fa9491d341a72a55363</citedby><cites>FETCH-LOGICAL-c457t-827ba6f2ebb2cba71b4f3f1d48bf821aae81a6147818b7fa9491d341a72a55363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091305710001954$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23651993$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20600247$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Figueiredo, Jozi G.</creatorcontrib><creatorcontrib>Bitencourt, Flavio S.</creatorcontrib><creatorcontrib>Cunha, Thiago M.</creatorcontrib><creatorcontrib>Luz, Patrícia B.</creatorcontrib><creatorcontrib>Nascimento, Kyria S.</creatorcontrib><creatorcontrib>Mota, Mario R.L.</creatorcontrib><creatorcontrib>Sampaio, Alexandre H.</creatorcontrib><creatorcontrib>Cavada, Benildo S.</creatorcontrib><creatorcontrib>Cunha, Fernando Q.</creatorcontrib><creatorcontrib>Alencar, Nylane M.N.</creatorcontrib><title>Agglutinin isolated from the red marine alga Hypnea cervicornis J. Agardh reduces inflammatory hypernociception: Involvement of nitric oxide</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Hypnea cervicornis agglutinin (HCA), a lectin isolated from the red marine alga has been previously shown to have an antinociceptive effect. In the present study in rats, mechanisms of action of HCA were addressed regarding mechanical hypernociception induced by carrageenan, ovalbumin (as antigen), and also by prostaglandin E
2 in rats. The lectin administered intravenously inhibited carrageenan- and antigen-induced hypernociception at 1, 3, 5 and 7
h. This inhibitory effect was completely prevented when lectin was combined with mucin, demonstrating the role of carbohydrate-binding sites. The inhibition of inflammatory hypernociception by HCA was associated with the prevention of neutrophil recruitment to the plantar tissue of rats but was not associated with the inhibition of the release of pro-hypernociceptive cytokines (TNF-α, IL-1β and CINC-1). HCA also blocked mechanical hypernociception induced by PGE
2, which was prevented by the administration of nitric oxide synthase inhibitors. These results were corroborated by the increased circulating levels of NO metabolites following HCA treatment. These findings suggest that the anti-hypernociceptive effects of HCA are not associated with the inhibition of pro-inflammatory cytokine production. However, these effects seem to involve the inhibition of neutrophil migration and also the increase in NO production.</description><subject>Agglutinins</subject><subject>Agglutinins - isolation & purification</subject><subject>Agglutinins - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cytokines - biosynthesis</subject><subject>Hyperalgesia - prevention & control</subject><subject>Hypernociception</subject><subject>Hypnea cervicornis</subject><subject>Inflammation</subject><subject>Inflammation - prevention & control</subject><subject>Lectin</subject><subject>Medical sciences</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - physiology</subject><subject>Peroxidase - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rhodophyta - chemistry</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P0zAQhi0EYrsLP4AL8gVxShg7H07gVK1gd9FKXOBsTZxx6yqxg51W9D_wo0nVAjc4jV7pmdHofRh7JSAXIOp3u3zqulzCkqHOAZonbCUaVWSVUOopWwG0IiugUlfsOqUdAJSyVs_ZlYQaQJZqxX6uN5thPzvvPHcpDDhTz20MI5-3xOMSRozOE8dhg_z-OHlCbigenAnRu8Q_53y9wdhvT_DeUOLO2wHHEecQj3x7nCj6YJyhaXbBv-cP_hCGA43kZx4s926OzvDww_X0gj2zOCR6eZk37Nunj19v77PHL3cPt-vHzJSVmrNGqg5rK6nrpOlQia60hRV92XS2kQKRGoG1KFUjmk5ZbMtW9EUpUEmsqqIubtjb890phu97SrMeXTI0DOgp7JNuhKpBCoD_kqoqQUho5UKKM2liSCmS1VN0S3dHLUCfbOmdXmzpky0NtV5sLTuvL9f33Uj9n43fehbgzQXAZHCwEb1x6S9X1JVo22LhPpw5Wlo7OIo6GUfeUO8imVn3wf3jjV9VWbQn</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Figueiredo, Jozi G.</creator><creator>Bitencourt, Flavio S.</creator><creator>Cunha, Thiago M.</creator><creator>Luz, Patrícia B.</creator><creator>Nascimento, Kyria S.</creator><creator>Mota, Mario R.L.</creator><creator>Sampaio, Alexandre H.</creator><creator>Cavada, Benildo S.</creator><creator>Cunha, Fernando Q.</creator><creator>Alencar, Nylane M.N.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope><scope>M7N</scope></search><sort><creationdate>20101001</creationdate><title>Agglutinin isolated from the red marine alga Hypnea cervicornis J. 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Agardh reduces inflammatory hypernociception: Involvement of nitric oxide</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>96</volume><issue>4</issue><spage>371</spage><epage>377</epage><pages>371-377</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Hypnea cervicornis agglutinin (HCA), a lectin isolated from the red marine alga has been previously shown to have an antinociceptive effect. In the present study in rats, mechanisms of action of HCA were addressed regarding mechanical hypernociception induced by carrageenan, ovalbumin (as antigen), and also by prostaglandin E
2 in rats. The lectin administered intravenously inhibited carrageenan- and antigen-induced hypernociception at 1, 3, 5 and 7
h. This inhibitory effect was completely prevented when lectin was combined with mucin, demonstrating the role of carbohydrate-binding sites. The inhibition of inflammatory hypernociception by HCA was associated with the prevention of neutrophil recruitment to the plantar tissue of rats but was not associated with the inhibition of the release of pro-hypernociceptive cytokines (TNF-α, IL-1β and CINC-1). HCA also blocked mechanical hypernociception induced by PGE
2, which was prevented by the administration of nitric oxide synthase inhibitors. These results were corroborated by the increased circulating levels of NO metabolites following HCA treatment. These findings suggest that the anti-hypernociceptive effects of HCA are not associated with the inhibition of pro-inflammatory cytokine production. However, these effects seem to involve the inhibition of neutrophil migration and also the increase in NO production.</abstract><cop>Kidlington</cop><pub>Elsevier Inc</pub><pmid>20600247</pmid><doi>10.1016/j.pbb.2010.06.008</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Agglutinins Agglutinins - isolation & purification Agglutinins - pharmacology Animals Biological and medical sciences Cytokines - biosynthesis Hyperalgesia - prevention & control Hypernociception Hypnea cervicornis Inflammation Inflammation - prevention & control Lectin Medical sciences Nitric oxide Nitric Oxide - physiology Peroxidase - metabolism Rats Rats, Wistar Rhodophyta - chemistry |
| title | Agglutinin isolated from the red marine alga Hypnea cervicornis J. Agardh reduces inflammatory hypernociception: Involvement of nitric oxide |
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