OXYGENATION PROPERTIES AND 2, 3-DIPHOSPHOGLYCERATE OF HUMAN ADULT AND FETAL BLOOD
Oxygen dissociation curves of human adult and cord blood were constructed over a wide range of pH values (5.9-8.7). The cord blood was characterized by a high oxygen affinity as compared with adult blood in the pH region above 6.3. Below that pH region the relationship was reversed. The intracellula...
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| Veröffentlicht in: | Japanese journal of physiology 1972, Vol.22(5), pp.557-568 |
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| container_end_page | 568 |
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| container_issue | 5 |
| container_start_page | 557 |
| container_title | Japanese journal of physiology |
| container_volume | 22 |
| creator | ENOKI, Yasunori YASUMITSU, Yo TOMITA, Susumu MAEDA, Nobuji OKUDA, Takao |
| description | Oxygen dissociation curves of human adult and cord blood were constructed over a wide range of pH values (5.9-8.7). The cord blood was characterized by a high oxygen affinity as compared with adult blood in the pH region above 6.3. Below that pH region the relationship was reversed. The intracellular pH and 2, 3-diphosphoglycerate (DPG) content of red cells of these two kinds of blood were little different. Upon their incubation at 38°C, both kinds of blood showed an increase in oxygen affinity concomitant with a decrease in the DPG content. From these experiments with the two sorts of blood incubated for various lengths of time it was concluded that the higher oxygen affinity of fetal blood was due mostly to the predominant presence of hemoglobin F, which is not different in oxygen affinity from hemoglobin A but which is quite different in susceptibility to the inhibitory effect of DPG upon oxygen affinity. |
| doi_str_mv | 10.2170/jjphysiol.22.557 |
| format | Article |
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The cord blood was characterized by a high oxygen affinity as compared with adult blood in the pH region above 6.3. Below that pH region the relationship was reversed. The intracellular pH and 2, 3-diphosphoglycerate (DPG) content of red cells of these two kinds of blood were little different. Upon their incubation at 38°C, both kinds of blood showed an increase in oxygen affinity concomitant with a decrease in the DPG content. From these experiments with the two sorts of blood incubated for various lengths of time it was concluded that the higher oxygen affinity of fetal blood was due mostly to the predominant presence of hemoglobin F, which is not different in oxygen affinity from hemoglobin A but which is quite different in susceptibility to the inhibitory effect of DPG upon oxygen affinity.</description><identifier>ISSN: 0021-521X</identifier><identifier>EISSN: 1881-1396</identifier><identifier>DOI: 10.2170/jjphysiol.22.557</identifier><identifier>PMID: 4539648</identifier><language>eng</language><publisher>Japan: THE PHYSIOLOGICAL SOCIETY OF JAPAN</publisher><subject>Blood ; Diphosphoglyceric Acids - blood ; Erythrocytes - analysis ; Fetal Hemoglobin - analysis ; Fetus ; Glyceric Acids - blood ; Humans ; Hydrogen-Ion Concentration ; Methemoglobin - analysis ; Organophosphorus Compounds - blood ; Oxygen - blood ; Umbilical Cord</subject><ispartof>The Japanese Journal of Physiology, 1972, Vol.22(5), pp.557-568</ispartof><rights>Physiological Society of Japan</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-238172500906d2dc0863efde5d6bd23539fcae38e5e3527c14ce77e05cfe528a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4539648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ENOKI, Yasunori</creatorcontrib><creatorcontrib>YASUMITSU, Yo</creatorcontrib><creatorcontrib>TOMITA, Susumu</creatorcontrib><creatorcontrib>MAEDA, Nobuji</creatorcontrib><creatorcontrib>OKUDA, Takao</creatorcontrib><title>OXYGENATION PROPERTIES AND 2, 3-DIPHOSPHOGLYCERATE OF HUMAN ADULT AND FETAL BLOOD</title><title>Japanese journal of physiology</title><addtitle>Jpn J Physiol</addtitle><description>Oxygen dissociation curves of human adult and cord blood were constructed over a wide range of pH values (5.9-8.7). The cord blood was characterized by a high oxygen affinity as compared with adult blood in the pH region above 6.3. Below that pH region the relationship was reversed. The intracellular pH and 2, 3-diphosphoglycerate (DPG) content of red cells of these two kinds of blood were little different. Upon their incubation at 38°C, both kinds of blood showed an increase in oxygen affinity concomitant with a decrease in the DPG content. From these experiments with the two sorts of blood incubated for various lengths of time it was concluded that the higher oxygen affinity of fetal blood was due mostly to the predominant presence of hemoglobin F, which is not different in oxygen affinity from hemoglobin A but which is quite different in susceptibility to the inhibitory effect of DPG upon oxygen affinity.</description><subject>Blood</subject><subject>Diphosphoglyceric Acids - blood</subject><subject>Erythrocytes - analysis</subject><subject>Fetal Hemoglobin - analysis</subject><subject>Fetus</subject><subject>Glyceric Acids - blood</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Methemoglobin - analysis</subject><subject>Organophosphorus Compounds - blood</subject><subject>Oxygen - blood</subject><subject>Umbilical Cord</subject><issn>0021-521X</issn><issn>1881-1396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9vgjAYhptli3Nu912WcNppuP6ggEcmqCRMnGKipwbLx5SgOKoH__t1YtyhbZr3-Z58eRF6JrhLiYPfi2K_PqlNVXYp7XLu3KA2cV1iEtazb1EbY0pMTsniHj0oVeivbdlWC7UsrgHLbaOveLEcBmMvCeOxMZnGk2CahMHM8Ma-Qd8MZvrhZBTP9BlGy34w9ZLAiAfGaP7pjQ3Pn0fJGR0EiRcZH1Ec-4_oLk9LBU-Xt4PmOu2PzCgehn0vMiWn_GBS5hKHcox72M5oJrFrM8gz4Jm9yijT--UyBeYCB8apI4klwXEAc5kDp27KOui18e7r6ucI6iC2GyWhLNMdVEclXGL3tJxqEDegrCulasjFvt5s0_okCBZ_LYpri4JSoVvUIy8X93G1hew6cKlN52GTF-qQfsM1T-vDRpbwLyQ9js_S5tLuKyPXaS1gx34BdU-C1w</recordid><startdate>19720101</startdate><enddate>19720101</enddate><creator>ENOKI, Yasunori</creator><creator>YASUMITSU, Yo</creator><creator>TOMITA, Susumu</creator><creator>MAEDA, Nobuji</creator><creator>OKUDA, Takao</creator><general>THE PHYSIOLOGICAL SOCIETY OF JAPAN</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19720101</creationdate><title>OXYGENATION PROPERTIES AND 2, 3-DIPHOSPHOGLYCERATE OF HUMAN ADULT AND FETAL BLOOD</title><author>ENOKI, Yasunori ; YASUMITSU, Yo ; TOMITA, Susumu ; MAEDA, Nobuji ; OKUDA, Takao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-238172500906d2dc0863efde5d6bd23539fcae38e5e3527c14ce77e05cfe528a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Blood</topic><topic>Diphosphoglyceric Acids - blood</topic><topic>Erythrocytes - analysis</topic><topic>Fetal Hemoglobin - analysis</topic><topic>Fetus</topic><topic>Glyceric Acids - blood</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Methemoglobin - analysis</topic><topic>Organophosphorus Compounds - blood</topic><topic>Oxygen - blood</topic><topic>Umbilical Cord</topic><toplevel>online_resources</toplevel><creatorcontrib>ENOKI, Yasunori</creatorcontrib><creatorcontrib>YASUMITSU, Yo</creatorcontrib><creatorcontrib>TOMITA, Susumu</creatorcontrib><creatorcontrib>MAEDA, Nobuji</creatorcontrib><creatorcontrib>OKUDA, Takao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ENOKI, Yasunori</au><au>YASUMITSU, Yo</au><au>TOMITA, Susumu</au><au>MAEDA, Nobuji</au><au>OKUDA, Takao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>OXYGENATION PROPERTIES AND 2, 3-DIPHOSPHOGLYCERATE OF HUMAN ADULT AND FETAL BLOOD</atitle><jtitle>Japanese journal of physiology</jtitle><addtitle>Jpn J Physiol</addtitle><date>1972-01-01</date><risdate>1972</risdate><volume>22</volume><issue>5</issue><spage>557</spage><epage>568</epage><pages>557-568</pages><issn>0021-521X</issn><eissn>1881-1396</eissn><abstract>Oxygen dissociation curves of human adult and cord blood were constructed over a wide range of pH values (5.9-8.7). The cord blood was characterized by a high oxygen affinity as compared with adult blood in the pH region above 6.3. Below that pH region the relationship was reversed. The intracellular pH and 2, 3-diphosphoglycerate (DPG) content of red cells of these two kinds of blood were little different. Upon their incubation at 38°C, both kinds of blood showed an increase in oxygen affinity concomitant with a decrease in the DPG content. From these experiments with the two sorts of blood incubated for various lengths of time it was concluded that the higher oxygen affinity of fetal blood was due mostly to the predominant presence of hemoglobin F, which is not different in oxygen affinity from hemoglobin A but which is quite different in susceptibility to the inhibitory effect of DPG upon oxygen affinity.</abstract><cop>Japan</cop><pub>THE PHYSIOLOGICAL SOCIETY OF JAPAN</pub><pmid>4539648</pmid><doi>10.2170/jjphysiol.22.557</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0021-521X |
| ispartof | The Japanese Journal of Physiology, 1972, Vol.22(5), pp.557-568 |
| issn | 0021-521X 1881-1396 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Blood Diphosphoglyceric Acids - blood Erythrocytes - analysis Fetal Hemoglobin - analysis Fetus Glyceric Acids - blood Humans Hydrogen-Ion Concentration Methemoglobin - analysis Organophosphorus Compounds - blood Oxygen - blood Umbilical Cord |
| title | OXYGENATION PROPERTIES AND 2, 3-DIPHOSPHOGLYCERATE OF HUMAN ADULT AND FETAL BLOOD |
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