Th1/Th2 cytokine gene polymorphisms in patients with uterine fibroid
Uterine fibroid or leiomyoma is a frequent non-malignant tumour with unknown aetiology and pathogenesis. The aim of our study was to look for possible genetic markers which could be used as prognostic tools for evaluation of an increased risk for development of uterine fibroid. A large spectrum of T...
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| Veröffentlicht in: | Folia biologica 2010-01, Vol.56 (5), p.206-210 |
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| creator | Sosna, O Kolesár, L Slavčev, A Skibová, J Fait, T Mara, M Stříž, I Kužel, D |
| description | Uterine fibroid or leiomyoma is a frequent non-malignant tumour with unknown aetiology and pathogenesis. The aim of our study was to look for possible genetic markers which could be used as prognostic tools for evaluation of an increased risk for development of uterine fibroid. A large spectrum of Th1/Th2 cytokine gene polymorphisms in 102 patients with uterine leiomyoma was compared with 145 healthy controls. An association between polymorphisms of the IL4 gene promotor at positions -590 C/T and -33 C/T, and the risk of leiomyoma was observed. The CC genotype of IL4 -590 and at position -33 was less frequent in the patient group than in the control group (P = 0.03). Besides IL-4, we observed different genotype distribution of the TNFA gene -308 A/G. The frequency of genotype AA was higher in the younger (≤ 35 years) patient group (P = 0.02). Our study thus suggests that certain cytokine gene polymorphisms, especially of the IL4 and TNFA genes, may be associated with increased risk for development of uterine fibroid. Further investigation would be needed to elucidate the mechanisms responsible for these associations. |
| doi_str_mv | 10.14712/fb2010056050206 |
| format | Article |
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The aim of our study was to look for possible genetic markers which could be used as prognostic tools for evaluation of an increased risk for development of uterine fibroid. A large spectrum of Th1/Th2 cytokine gene polymorphisms in 102 patients with uterine leiomyoma was compared with 145 healthy controls. An association between polymorphisms of the IL4 gene promotor at positions -590 C/T and -33 C/T, and the risk of leiomyoma was observed. The CC genotype of IL4 -590 and at position -33 was less frequent in the patient group than in the control group (P = 0.03). Besides IL-4, we observed different genotype distribution of the TNFA gene -308 A/G. The frequency of genotype AA was higher in the younger (≤ 35 years) patient group (P = 0.02). Our study thus suggests that certain cytokine gene polymorphisms, especially of the IL4 and TNFA genes, may be associated with increased risk for development of uterine fibroid. Further investigation would be needed to elucidate the mechanisms responsible for these associations.</description><identifier>ISSN: 0015-5500</identifier><identifier>EISSN: 2533-7602</identifier><identifier>DOI: 10.14712/fb2010056050206</identifier><identifier>PMID: 21138652</identifier><language>eng</language><publisher>Czech Republic: Charles University in Prague, First Faculty of Medicine</publisher><subject>Adult ; Cytokines - genetics ; Female ; Genetic Markers ; Genetic Predisposition to Disease ; Genotype ; Humans ; Leiomyoma - genetics ; Leiomyoma - pathology ; Middle Aged ; Polymorphism, Genetic ; Promoter Regions, Genetic ; Th1 Cells - physiology ; Th2 Cells - physiology ; Young Adult</subject><ispartof>Folia biologica, 2010-01, Vol.56 (5), p.206-210</ispartof><rights>Copyright Charles University in Prague, First Faculty of Medicine 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c278t-d2d4ff31be2481df62cdd315fc01be01cd808bddc1a6942fe0d41d39b6f2e3033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21138652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sosna, O</creatorcontrib><creatorcontrib>Kolesár, L</creatorcontrib><creatorcontrib>Slavčev, A</creatorcontrib><creatorcontrib>Skibová, J</creatorcontrib><creatorcontrib>Fait, T</creatorcontrib><creatorcontrib>Mara, M</creatorcontrib><creatorcontrib>Stříž, I</creatorcontrib><creatorcontrib>Kužel, D</creatorcontrib><title>Th1/Th2 cytokine gene polymorphisms in patients with uterine fibroid</title><title>Folia biologica</title><addtitle>Folia Biol (Praha)</addtitle><description>Uterine fibroid or leiomyoma is a frequent non-malignant tumour with unknown aetiology and pathogenesis. The aim of our study was to look for possible genetic markers which could be used as prognostic tools for evaluation of an increased risk for development of uterine fibroid. A large spectrum of Th1/Th2 cytokine gene polymorphisms in 102 patients with uterine leiomyoma was compared with 145 healthy controls. An association between polymorphisms of the IL4 gene promotor at positions -590 C/T and -33 C/T, and the risk of leiomyoma was observed. The CC genotype of IL4 -590 and at position -33 was less frequent in the patient group than in the control group (P = 0.03). Besides IL-4, we observed different genotype distribution of the TNFA gene -308 A/G. The frequency of genotype AA was higher in the younger (≤ 35 years) patient group (P = 0.02). Our study thus suggests that certain cytokine gene polymorphisms, especially of the IL4 and TNFA genes, may be associated with increased risk for development of uterine fibroid. 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The aim of our study was to look for possible genetic markers which could be used as prognostic tools for evaluation of an increased risk for development of uterine fibroid. A large spectrum of Th1/Th2 cytokine gene polymorphisms in 102 patients with uterine leiomyoma was compared with 145 healthy controls. An association between polymorphisms of the IL4 gene promotor at positions -590 C/T and -33 C/T, and the risk of leiomyoma was observed. The CC genotype of IL4 -590 and at position -33 was less frequent in the patient group than in the control group (P = 0.03). Besides IL-4, we observed different genotype distribution of the TNFA gene -308 A/G. The frequency of genotype AA was higher in the younger (≤ 35 years) patient group (P = 0.02). Our study thus suggests that certain cytokine gene polymorphisms, especially of the IL4 and TNFA genes, may be associated with increased risk for development of uterine fibroid. Further investigation would be needed to elucidate the mechanisms responsible for these associations.</abstract><cop>Czech Republic</cop><pub>Charles University in Prague, First Faculty of Medicine</pub><pmid>21138652</pmid><doi>10.14712/fb2010056050206</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Cytokines - genetics Female Genetic Markers Genetic Predisposition to Disease Genotype Humans Leiomyoma - genetics Leiomyoma - pathology Middle Aged Polymorphism, Genetic Promoter Regions, Genetic Th1 Cells - physiology Th2 Cells - physiology Young Adult |
| title | Th1/Th2 cytokine gene polymorphisms in patients with uterine fibroid |
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