Hepatitis C virus treatment rates and outcomes in HIV/hepatitis C virus co-infected individuals at an urban HIV clinic
OBJECTIVESThe factors associated with hepatitis C virus (HCV) treatment uptake and responses were assessed among HCV/HIV co-infected individuals referred for HCV therapy at an urban HIV clinic. METHODSRetrospective review of HIV/HCV patients enrolled in the HCV treatment program at the John Ruedy Im...
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| Veröffentlicht in: | European journal of gastroenterology & hepatology 2011-01, Vol.23 (1), p.45-50 |
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| container_title | European journal of gastroenterology & hepatology |
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| creator | Murray, Melanie C.M Barrios, Rolando Zhang, Wendy Hull, Mark Montessori, Valentina Hogg, Robert S Montaner, Julio S.G |
| description | OBJECTIVESThe factors associated with hepatitis C virus (HCV) treatment uptake and responses were assessed among HCV/HIV co-infected individuals referred for HCV therapy at an urban HIV clinic.
METHODSRetrospective review of HIV/HCV patients enrolled in the HCV treatment program at the John Ruedy Immunodeficiency Clinic in Vancouver. The factors associated with treatment uptake were assessed using multivariate analysis.
RESULTSA total of 134 HCV/HIV co-infected individuals were recalled for assessment for HCV therapy. Overall 64 (48%) initiated treatment, and of those treated 49 (76.6%) attained end treatment response, whereas 35 (57.8%) achieved sustained virological response (SVR). When evaluated by genotype, 53% (17/32) of those with genotype 1, and 65% (20/31) of those with genotype 2 or 3 infections attained SVR. In treated individuals, alanine aminotransferase dropped significantly after treatment (P |
| doi_str_mv | 10.1097/MEG.0b013e328341ef54 |
| format | Article |
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METHODSRetrospective review of HIV/HCV patients enrolled in the HCV treatment program at the John Ruedy Immunodeficiency Clinic in Vancouver. The factors associated with treatment uptake were assessed using multivariate analysis.
RESULTSA total of 134 HCV/HIV co-infected individuals were recalled for assessment for HCV therapy. Overall 64 (48%) initiated treatment, and of those treated 49 (76.6%) attained end treatment response, whereas 35 (57.8%) achieved sustained virological response (SVR). When evaluated by genotype, 53% (17/32) of those with genotype 1, and 65% (20/31) of those with genotype 2 or 3 infections attained SVR. In treated individuals, alanine aminotransferase dropped significantly after treatment (P<0.001). During treatment, CD4 counts dropped significantly (P<0.001) in all patients. The counts recovered to baseline in patients who achieved SVR, but remained lower in patients who failed the therapy (P=0.015). On multivariate analysis, history of injection drug use (odds ratio3.48; 95% confidence interval1.37–8.79; P=0.009) and low hemoglobin levels (odds ratio4.23; 95% confidence interval1.36–13.10; P=0.013) were associated with those who did not enter the treatment.
CONCLUSIONOnly half of treatment-eligible co-infected patients referred for the therapy initiated treatment. Of those referred for the therapy, history of injection drug use was associated with lower rates of treatment uptake. Treated HIV/HCV co-infected individuals benefitted from both decreased alanine aminotransferase (independent of SVR), and rates of SVR similar to those described in HCV monoinfected patients.</description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>DOI: 10.1097/MEG.0b013e328341ef54</identifier><identifier>PMID: 21139470</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Alanine Transaminase - blood ; Biological and medical sciences ; CD4 Lymphocyte Count ; Comorbidity ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hemoglobins - metabolism ; Hepacivirus - drug effects ; Hepacivirus - immunology ; Hepacivirus - isolation & purification ; Hepatitis C - drug therapy ; Hepatitis C - epidemiology ; Hepatitis C - immunology ; Hepatitis C - virology ; HIV Infections - epidemiology ; HIV Infections - immunology ; HIV Infections - virology ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Retrospective Studies ; Substance Abuse, Intravenous - epidemiology ; Treatment Outcome ; Urban Health Services - statistics & numerical data ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>European journal of gastroenterology & hepatology, 2011-01, Vol.23 (1), p.45-50</ispartof><rights>2011 Lippincott Williams & Wilkins, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3817-a316aed2ccf0ec4501359b710420c1fc8f64d877b0bc853d91cccae437d6da523</citedby><cites>FETCH-LOGICAL-c3817-a316aed2ccf0ec4501359b710420c1fc8f64d877b0bc853d91cccae437d6da523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23692973$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21139470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murray, Melanie C.M</creatorcontrib><creatorcontrib>Barrios, Rolando</creatorcontrib><creatorcontrib>Zhang, Wendy</creatorcontrib><creatorcontrib>Hull, Mark</creatorcontrib><creatorcontrib>Montessori, Valentina</creatorcontrib><creatorcontrib>Hogg, Robert S</creatorcontrib><creatorcontrib>Montaner, Julio S.G</creatorcontrib><title>Hepatitis C virus treatment rates and outcomes in HIV/hepatitis C virus co-infected individuals at an urban HIV clinic</title><title>European journal of gastroenterology & hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description>OBJECTIVESThe factors associated with hepatitis C virus (HCV) treatment uptake and responses were assessed among HCV/HIV co-infected individuals referred for HCV therapy at an urban HIV clinic.
METHODSRetrospective review of HIV/HCV patients enrolled in the HCV treatment program at the John Ruedy Immunodeficiency Clinic in Vancouver. The factors associated with treatment uptake were assessed using multivariate analysis.
RESULTSA total of 134 HCV/HIV co-infected individuals were recalled for assessment for HCV therapy. Overall 64 (48%) initiated treatment, and of those treated 49 (76.6%) attained end treatment response, whereas 35 (57.8%) achieved sustained virological response (SVR). When evaluated by genotype, 53% (17/32) of those with genotype 1, and 65% (20/31) of those with genotype 2 or 3 infections attained SVR. In treated individuals, alanine aminotransferase dropped significantly after treatment (P<0.001). During treatment, CD4 counts dropped significantly (P<0.001) in all patients. The counts recovered to baseline in patients who achieved SVR, but remained lower in patients who failed the therapy (P=0.015). On multivariate analysis, history of injection drug use (odds ratio3.48; 95% confidence interval1.37–8.79; P=0.009) and low hemoglobin levels (odds ratio4.23; 95% confidence interval1.36–13.10; P=0.013) were associated with those who did not enter the treatment.
CONCLUSIONOnly half of treatment-eligible co-infected patients referred for the therapy initiated treatment. Of those referred for the therapy, history of injection drug use was associated with lower rates of treatment uptake. Treated HIV/HCV co-infected individuals benefitted from both decreased alanine aminotransferase (independent of SVR), and rates of SVR similar to those described in HCV monoinfected patients.</description><subject>Adult</subject><subject>Alanine Transaminase - blood</subject><subject>Biological and medical sciences</subject><subject>CD4 Lymphocyte Count</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hemoglobins - metabolism</subject><subject>Hepacivirus - drug effects</subject><subject>Hepacivirus - immunology</subject><subject>Hepacivirus - isolation & purification</subject><subject>Hepatitis C - drug therapy</subject><subject>Hepatitis C - epidemiology</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C - virology</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Substance Abuse, Intravenous - epidemiology</subject><subject>Treatment Outcome</subject><subject>Urban Health Services - statistics & numerical data</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkE1v1DAQhi0EapfSf4CQL4hTWk_sxPERrdpupaJeAHGLnPFEa8jHYjtb9d_j0i2V6MGyRvM8M5qXsfcgzkAYff7l4upMdAIkybKRCqiv1Cu2AqVlUdWNfs1WwlSqqA38OGZvY_wpBGgJ-ogdlwDSKC1WbL-hnU0--cjXfO_DEnkKZNNIU-LBJorcTo7PS8J5zIWf-Ob6-_n2hYVz4aeeMJHLkPN77xY7ZDvlAXwJnf1rchz85PEde9PnLp0e_hP27fLi63pT3NxeXa8_3xQoG9CFlVBbciViLwhVla-tTKdBqFIg9Nj0tXKN1p3osKmkM4CIlpTUrna2KuUJ-_Q4dxfm3wvF1I4-Ig2DnWheYttArY0CeCDVI4lhjjFQ3-6CH224b0G0D4G3OfD2_8Cz9uGwYOlGcv-kp4Qz8PEA2Ih26IOd0MdnTtamNFo-77-bh0Qh_hqWOwrtluyQtq0Q-WQtdVEKAAG5LPITWv4BxomaTQ</recordid><startdate>201101</startdate><enddate>201101</enddate><creator>Murray, Melanie C.M</creator><creator>Barrios, Rolando</creator><creator>Zhang, Wendy</creator><creator>Hull, Mark</creator><creator>Montessori, Valentina</creator><creator>Hogg, Robert S</creator><creator>Montaner, Julio S.G</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201101</creationdate><title>Hepatitis C virus treatment rates and outcomes in HIV/hepatitis C virus co-infected individuals at an urban HIV clinic</title><author>Murray, Melanie C.M ; Barrios, Rolando ; Zhang, Wendy ; Hull, Mark ; Montessori, Valentina ; Hogg, Robert S ; Montaner, Julio S.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3817-a316aed2ccf0ec4501359b710420c1fc8f64d877b0bc853d91cccae437d6da523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Alanine Transaminase - blood</topic><topic>Biological and medical sciences</topic><topic>CD4 Lymphocyte Count</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hemoglobins - metabolism</topic><topic>Hepacivirus - drug effects</topic><topic>Hepacivirus - immunology</topic><topic>Hepacivirus - isolation & purification</topic><topic>Hepatitis C - drug therapy</topic><topic>Hepatitis C - epidemiology</topic><topic>Hepatitis C - immunology</topic><topic>Hepatitis C - virology</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - virology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Substance Abuse, Intravenous - epidemiology</topic><topic>Treatment Outcome</topic><topic>Urban Health Services - statistics & numerical data</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murray, Melanie C.M</creatorcontrib><creatorcontrib>Barrios, Rolando</creatorcontrib><creatorcontrib>Zhang, Wendy</creatorcontrib><creatorcontrib>Hull, Mark</creatorcontrib><creatorcontrib>Montessori, Valentina</creatorcontrib><creatorcontrib>Hogg, Robert S</creatorcontrib><creatorcontrib>Montaner, Julio S.G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murray, Melanie C.M</au><au>Barrios, Rolando</au><au>Zhang, Wendy</au><au>Hull, Mark</au><au>Montessori, Valentina</au><au>Hogg, Robert S</au><au>Montaner, Julio S.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis C virus treatment rates and outcomes in HIV/hepatitis C virus co-infected individuals at an urban HIV clinic</atitle><jtitle>European journal of gastroenterology & hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>2011-01</date><risdate>2011</risdate><volume>23</volume><issue>1</issue><spage>45</spage><epage>50</epage><pages>45-50</pages><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract>OBJECTIVESThe factors associated with hepatitis C virus (HCV) treatment uptake and responses were assessed among HCV/HIV co-infected individuals referred for HCV therapy at an urban HIV clinic.
METHODSRetrospective review of HIV/HCV patients enrolled in the HCV treatment program at the John Ruedy Immunodeficiency Clinic in Vancouver. The factors associated with treatment uptake were assessed using multivariate analysis.
RESULTSA total of 134 HCV/HIV co-infected individuals were recalled for assessment for HCV therapy. Overall 64 (48%) initiated treatment, and of those treated 49 (76.6%) attained end treatment response, whereas 35 (57.8%) achieved sustained virological response (SVR). When evaluated by genotype, 53% (17/32) of those with genotype 1, and 65% (20/31) of those with genotype 2 or 3 infections attained SVR. In treated individuals, alanine aminotransferase dropped significantly after treatment (P<0.001). During treatment, CD4 counts dropped significantly (P<0.001) in all patients. The counts recovered to baseline in patients who achieved SVR, but remained lower in patients who failed the therapy (P=0.015). On multivariate analysis, history of injection drug use (odds ratio3.48; 95% confidence interval1.37–8.79; P=0.009) and low hemoglobin levels (odds ratio4.23; 95% confidence interval1.36–13.10; P=0.013) were associated with those who did not enter the treatment.
CONCLUSIONOnly half of treatment-eligible co-infected patients referred for the therapy initiated treatment. Of those referred for the therapy, history of injection drug use was associated with lower rates of treatment uptake. Treated HIV/HCV co-infected individuals benefitted from both decreased alanine aminotransferase (independent of SVR), and rates of SVR similar to those described in HCV monoinfected patients.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>21139470</pmid><doi>10.1097/MEG.0b013e328341ef54</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Alanine Transaminase - blood Biological and medical sciences CD4 Lymphocyte Count Comorbidity Female Gastroenterology. Liver. Pancreas. Abdomen Hemoglobins - metabolism Hepacivirus - drug effects Hepacivirus - immunology Hepacivirus - isolation & purification Hepatitis C - drug therapy Hepatitis C - epidemiology Hepatitis C - immunology Hepatitis C - virology HIV Infections - epidemiology HIV Infections - immunology HIV Infections - virology Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Middle Aged Retrospective Studies Substance Abuse, Intravenous - epidemiology Treatment Outcome Urban Health Services - statistics & numerical data Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Hepatitis C virus treatment rates and outcomes in HIV/hepatitis C virus co-infected individuals at an urban HIV clinic |
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