Towards Practical Baeyer-Villiger-Monooxygenases: Design of Cyclohexanone Monooxygenase Mutants with Enhanced Oxidative Stability

Baeyer-Villiger monooxygenases (BVMOs) catalyze the conversion of ketones and cyclic ketones into esters and lactones, respectively. Cyclohexanone monooxygenase (CHMO) from Acinetobacter sp. NCIMB 9871 is known to show an impressive substrate scope as well as exquisite chemo-, regio-, and enantiosel...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2010-12, Vol.11 (18), p.2589-2596
Hauptverfasser:	Opperman, Diederik J, Reetz, Manfred T
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter - enzymology Acinetobacter - genetics Baeyer-Villiger monooxygenases directed evolution Enzyme Stability Hydrogen Peroxide - metabolism Models, Molecular Mutation Oxidation-Reduction oxidative stability Oxygenases - chemistry Oxygenases - genetics Oxygenases - metabolism protein engineering Protein Engineering - methods Substrate Specificity Temperature thermostability
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