Antihyperglycemic, Antihyperlipidemic and Antiglycation Effects of Byrsonima crassifolia Fruit and Seed in Normal and Streptozotocin-Induced Diabetic Rats
The hypoglycemic effects of hexane, chloroform and methanol extracts from fruits and seeds of Byrsonima crassifolia were evaluated by oral administration to normoglycemic and streptozotocin-induced severe diabetic rats (SD). The anti-diabetic effect was examined by blood glucose, triglycerides, lipi...
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| Veröffentlicht in: | Plant foods for human nutrition (Dordrecht) 2010-12, Vol.65 (4), p.350-357 |
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| creator | Perez-Gutierrez, Rosa Martha Muñiz-Ramirez, Alethia Gomez Gomez, Yolanda Bautista Ramírez, Esther |
| description | The hypoglycemic effects of hexane, chloroform and methanol extracts from fruits and seeds of Byrsonima crassifolia were evaluated by oral administration to normoglycemic and streptozotocin-induced severe diabetic rats (SD). The anti-diabetic effect was examined by blood glucose, triglycerides, lipid peroxidation, total cholesterol levels in the serum, glycogen content of liver and skeletal muscles, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and oxidized glutathione (GSSG) levels. The most active extracts were obtained with hexane. Hexane and chloroform extracts from fruits and seeds of Byrsonima crassifolia increased the levels of SOD, GSH, GSSG and CAT, hepatic glycogen content, glucose-6-phosphatase (G6Pase) and the plasma insulin levels. They also decreased glucokinase (GK) and TBAR (thiobarbituric acid assay). In conclusion, Byrsonima crassifolia possesses significant antihyperglycemic properties after 4 h of a single oral dose. It can also improve hyperlipidemia and hyperinsulinemia in streptozotocin-induced diabetic rats. Both extracts exhibited significant inhibitory activity against AGEs (advanced glycation end products) formation with IC₅₀ values ranging from 94.3 to 138.7 μg/ml. Therefore, B. crassifolia can be considered as a potential safe anti-diabetic agent. |
| doi_str_mv | 10.1007/s11130-010-0181-5 |
| format | Article |
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The anti-diabetic effect was examined by blood glucose, triglycerides, lipid peroxidation, total cholesterol levels in the serum, glycogen content of liver and skeletal muscles, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and oxidized glutathione (GSSG) levels. The most active extracts were obtained with hexane. Hexane and chloroform extracts from fruits and seeds of Byrsonima crassifolia increased the levels of SOD, GSH, GSSG and CAT, hepatic glycogen content, glucose-6-phosphatase (G6Pase) and the plasma insulin levels. They also decreased glucokinase (GK) and TBAR (thiobarbituric acid assay). In conclusion, Byrsonima crassifolia possesses significant antihyperglycemic properties after 4 h of a single oral dose. It can also improve hyperlipidemia and hyperinsulinemia in streptozotocin-induced diabetic rats. Both extracts exhibited significant inhibitory activity against AGEs (advanced glycation end products) formation with IC₅₀ values ranging from 94.3 to 138.7 μg/ml. Therefore, B. crassifolia can be considered as a potential safe anti-diabetic agent.</description><identifier>ISSN: 0921-9668</identifier><identifier>EISSN: 1573-9104</identifier><identifier>DOI: 10.1007/s11130-010-0181-5</identifier><identifier>PMID: 20734144</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Administration, Oral ; Animals ; Anti-diabetic ; Antihyperlipidemia ; Biological and medical sciences ; Blood Glucose - analysis ; Byrsonima crassifolia ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Cholesterol - blood ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - prevention & control ; Ecology ; Food industries ; Food Science ; Fruit - chemistry ; Fruit and vegetable industries ; Fundamental and applied biological sciences. Psychology ; Glucose Tolerance Test ; Glycation End Products, Advanced - blood ; Glycogen - metabolism ; Hexane and chloroform extract ; Hypoglycemic Agents - pharmacology ; Hypolipidemic Agents - pharmacology ; Insulin - blood ; Liver - metabolism ; Male ; Malpighiaceae - chemistry ; Nutrition ; Original Paper ; Oxidative Stress ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Physiology ; Rats ; Rats, Wistar ; Seeds - chemistry ; Streptozocin ; Triglycerides - blood</subject><ispartof>Plant foods for human nutrition (Dordrecht), 2010-12, Vol.65 (4), p.350-357</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-1a100b5cc6823e4a89869e56345af463206a5fc00881dd61f9cd43c6a9adde3d3</citedby><cites>FETCH-LOGICAL-c397t-1a100b5cc6823e4a89869e56345af463206a5fc00881dd61f9cd43c6a9adde3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11130-010-0181-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11130-010-0181-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23686320$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20734144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perez-Gutierrez, Rosa Martha</creatorcontrib><creatorcontrib>Muñiz-Ramirez, Alethia</creatorcontrib><creatorcontrib>Gomez Gomez, Yolanda</creatorcontrib><creatorcontrib>Bautista Ramírez, Esther</creatorcontrib><title>Antihyperglycemic, Antihyperlipidemic and Antiglycation Effects of Byrsonima crassifolia Fruit and Seed in Normal and Streptozotocin-Induced Diabetic Rats</title><title>Plant foods for human nutrition (Dordrecht)</title><addtitle>Plant Foods Hum Nutr</addtitle><addtitle>Plant Foods Hum Nutr</addtitle><description>The hypoglycemic effects of hexane, chloroform and methanol extracts from fruits and seeds of Byrsonima crassifolia were evaluated by oral administration to normoglycemic and streptozotocin-induced severe diabetic rats (SD). The anti-diabetic effect was examined by blood glucose, triglycerides, lipid peroxidation, total cholesterol levels in the serum, glycogen content of liver and skeletal muscles, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and oxidized glutathione (GSSG) levels. The most active extracts were obtained with hexane. Hexane and chloroform extracts from fruits and seeds of Byrsonima crassifolia increased the levels of SOD, GSH, GSSG and CAT, hepatic glycogen content, glucose-6-phosphatase (G6Pase) and the plasma insulin levels. They also decreased glucokinase (GK) and TBAR (thiobarbituric acid assay). In conclusion, Byrsonima crassifolia possesses significant antihyperglycemic properties after 4 h of a single oral dose. It can also improve hyperlipidemia and hyperinsulinemia in streptozotocin-induced diabetic rats. Both extracts exhibited significant inhibitory activity against AGEs (advanced glycation end products) formation with IC₅₀ values ranging from 94.3 to 138.7 μg/ml. Therefore, B. crassifolia can be considered as a potential safe anti-diabetic agent.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Anti-diabetic</subject><subject>Antihyperlipidemia</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Byrsonima crassifolia</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Cholesterol - blood</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - prevention & control</subject><subject>Ecology</subject><subject>Food industries</subject><subject>Food Science</subject><subject>Fruit - chemistry</subject><subject>Fruit and vegetable industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose Tolerance Test</subject><subject>Glycation End Products, Advanced - blood</subject><subject>Glycogen - metabolism</subject><subject>Hexane and chloroform extract</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>Insulin - blood</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Malpighiaceae - chemistry</subject><subject>Nutrition</subject><subject>Original Paper</subject><subject>Oxidative Stress</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Seeds - chemistry</subject><subject>Streptozocin</subject><subject>Triglycerides - blood</subject><issn>0921-9668</issn><issn>1573-9104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS0EoreFB2AD2aBuCNhx4tjLUlqoVIFE6dqa65-Lq8RObWdxeRSeFqe5lB0La6Tj78xo5iD0iuD3BOP-QyKEUFxjsjxO6u4J2pCup7UguH2KNlg0pBaM8SN0nNIdLh7GuufoqME9bUnbbtDvM5_dz_1k4m7YKzM69a56lAY3Ob1oFXj9IC8QZBd8dWGtUTlVwVYf9zEF70aoVISUnA2Dg-oyzi4_GG-M0ZXz1dcQRxhWKUcz5fAr5KCcr6-8nlWBPjnYmlzmfYecXqBnFoZkXh7qCbq9vPhx_qW-_vb56vzsulZU9LkmUG6x7ZRivKGmBS44E6ZjtO3Atow2mEFnFcacE60ZsULplioGArQ2VNMTdLr2nWK4n03KcnRJmWEAb8KcJCesFxQzXkiykiqGlKKxcopl7biXBMslEbkmIksicklEdsXz-tB93o5GPzr-RlCAtwcAkoLBRvDKpX8cZXxZonDNyqXy5XcmyrswR18u89_pb1aThSBhF0vj25sGF4qIUnpC_wAbla8r</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Perez-Gutierrez, Rosa Martha</creator><creator>Muñiz-Ramirez, Alethia</creator><creator>Gomez Gomez, Yolanda</creator><creator>Bautista Ramírez, Esther</creator><general>Boston : Springer US</general><general>Springer US</general><general>Springer</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101201</creationdate><title>Antihyperglycemic, Antihyperlipidemic and Antiglycation Effects of Byrsonima crassifolia Fruit and Seed in Normal and Streptozotocin-Induced Diabetic Rats</title><author>Perez-Gutierrez, Rosa Martha ; Muñiz-Ramirez, Alethia ; Gomez Gomez, Yolanda ; Bautista Ramírez, Esther</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-1a100b5cc6823e4a89869e56345af463206a5fc00881dd61f9cd43c6a9adde3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Anti-diabetic</topic><topic>Antihyperlipidemia</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Byrsonima crassifolia</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Cholesterol - blood</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - prevention & control</topic><topic>Ecology</topic><topic>Food industries</topic><topic>Food Science</topic><topic>Fruit - chemistry</topic><topic>Fruit and vegetable industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose Tolerance Test</topic><topic>Glycation End Products, Advanced - blood</topic><topic>Glycogen - metabolism</topic><topic>Hexane and chloroform extract</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypolipidemic Agents - pharmacology</topic><topic>Insulin - blood</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Malpighiaceae - chemistry</topic><topic>Nutrition</topic><topic>Original Paper</topic><topic>Oxidative Stress</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Seeds - chemistry</topic><topic>Streptozocin</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perez-Gutierrez, Rosa Martha</creatorcontrib><creatorcontrib>Muñiz-Ramirez, Alethia</creatorcontrib><creatorcontrib>Gomez Gomez, Yolanda</creatorcontrib><creatorcontrib>Bautista Ramírez, Esther</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Plant foods for human nutrition (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perez-Gutierrez, Rosa Martha</au><au>Muñiz-Ramirez, Alethia</au><au>Gomez Gomez, Yolanda</au><au>Bautista Ramírez, Esther</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antihyperglycemic, Antihyperlipidemic and Antiglycation Effects of Byrsonima crassifolia Fruit and Seed in Normal and Streptozotocin-Induced Diabetic Rats</atitle><jtitle>Plant foods for human nutrition (Dordrecht)</jtitle><stitle>Plant Foods Hum Nutr</stitle><addtitle>Plant Foods Hum Nutr</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>65</volume><issue>4</issue><spage>350</spage><epage>357</epage><pages>350-357</pages><issn>0921-9668</issn><eissn>1573-9104</eissn><abstract>The hypoglycemic effects of hexane, chloroform and methanol extracts from fruits and seeds of Byrsonima crassifolia were evaluated by oral administration to normoglycemic and streptozotocin-induced severe diabetic rats (SD). The anti-diabetic effect was examined by blood glucose, triglycerides, lipid peroxidation, total cholesterol levels in the serum, glycogen content of liver and skeletal muscles, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and oxidized glutathione (GSSG) levels. The most active extracts were obtained with hexane. Hexane and chloroform extracts from fruits and seeds of Byrsonima crassifolia increased the levels of SOD, GSH, GSSG and CAT, hepatic glycogen content, glucose-6-phosphatase (G6Pase) and the plasma insulin levels. They also decreased glucokinase (GK) and TBAR (thiobarbituric acid assay). In conclusion, Byrsonima crassifolia possesses significant antihyperglycemic properties after 4 h of a single oral dose. It can also improve hyperlipidemia and hyperinsulinemia in streptozotocin-induced diabetic rats. Both extracts exhibited significant inhibitory activity against AGEs (advanced glycation end products) formation with IC₅₀ values ranging from 94.3 to 138.7 μg/ml. Therefore, B. crassifolia can be considered as a potential safe anti-diabetic agent.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>20734144</pmid><doi>10.1007/s11130-010-0181-5</doi><tpages>8</tpages></addata></record> |
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| subjects | Administration, Oral Animals Anti-diabetic Antihyperlipidemia Biological and medical sciences Blood Glucose - analysis Byrsonima crassifolia Chemistry Chemistry and Materials Science Chemistry/Food Science Cholesterol - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - prevention & control Ecology Food industries Food Science Fruit - chemistry Fruit and vegetable industries Fundamental and applied biological sciences. Psychology Glucose Tolerance Test Glycation End Products, Advanced - blood Glycogen - metabolism Hexane and chloroform extract Hypoglycemic Agents - pharmacology Hypolipidemic Agents - pharmacology Insulin - blood Liver - metabolism Male Malpighiaceae - chemistry Nutrition Original Paper Oxidative Stress Phytotherapy Plant Extracts - pharmacology Plant Physiology Rats Rats, Wistar Seeds - chemistry Streptozocin Triglycerides - blood |
| title | Antihyperglycemic, Antihyperlipidemic and Antiglycation Effects of Byrsonima crassifolia Fruit and Seed in Normal and Streptozotocin-Induced Diabetic Rats |
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