A CYTOCHEMICAL EVALUATION OF PYROANTIMONATE BINDING TO THE PLASMALEMMA OF BLOOD AND BONE MARROW CELLS AND ITS RELATIONSHIP TO CELLULAR MATURATION
Normal human blood and bone marrow cells exposed to the pyroantimonate reaction exhibit a selective binding of pyroantimonate to sites associated with the plasmalemma of neutrophilic leukocytes, erythrocytes and certain of their precursors. Chemical distinctions exist between the plasmalemma of diff...
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| Veröffentlicht in: | The journal of histochemistry and cytochemistry 1972-11, Vol.20 (11), p.880-895 |
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| container_end_page | 895 |
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| container_issue | 11 |
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| container_title | The journal of histochemistry and cytochemistry |
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| creator | ACKERMAN, G. ADOLPH CLARK, MICHAEL A |
| description | Normal human blood and bone marrow cells exposed to the pyroantimonate reaction exhibit a selective binding of pyroantimonate to sites associated with the plasmalemma of neutrophilic leukocytes, erythrocytes and certain of their precursors. Chemical distinctions exist between the plasmalemma of different types of blood and bone marrow cells, and major changes in the cationic binding ability of neutrophilic and erythrocytic cells can be correlated with different phases in their differentiation. Plasmalemmal pyroantimonate-osmium-reactive cation is bound with glycoprotein in the erythrocytic elements and to both phospholipid and glycoprotein moieties in neutrophilic cells. The cellular distribution, membrane localization and degree of membrane reactivity obtained with the pyroantimonate-osmium reaction is distinct from that obtained with Thorotrast and ruthenium red. |
| doi_str_mv | 10.1177/20.11.880 |
| format | Article |
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The cellular distribution, membrane localization and degree of membrane reactivity obtained with the pyroantimonate-osmium reaction is distinct from that obtained with Thorotrast and ruthenium red.</description><identifier>ISSN: 0022-1554</identifier><identifier>EISSN: 1551-5044</identifier><identifier>DOI: 10.1177/20.11.880</identifier><identifier>PMID: 4118198</identifier><language>eng</language><publisher>London, England: Histochemical Soc</publisher><subject>Adult ; Aldehydes ; Antimony ; Blood Cells ; Bone Marrow ; Bone Marrow Cells ; Cell Differentiation ; Erythrocytes ; Glycoproteins ; Histocytochemistry ; Humans ; Leukocytes ; Microscopy, Electron ; Neuraminidase ; Neutrophils ; Osmium ; Periodic Acid ; Protein Binding ; Ruthenium ; Semicarbazides ; Silver ; Staining and Labeling</subject><ispartof>The journal of histochemistry and cytochemistry, 1972-11, Vol.20 (11), p.880-895</ispartof><rights>1972, THE HISTOCHEMICAL SOCIETY, INC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-9de2e86a415a3b1247c5fc532fdf6eeeceed4a045adc4d4951bfb2697a0b250b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/20.11.880$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/20.11.880$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21824,27929,27930,43626,43627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4118198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ACKERMAN, G. ADOLPH</creatorcontrib><creatorcontrib>CLARK, MICHAEL A</creatorcontrib><title>A CYTOCHEMICAL EVALUATION OF PYROANTIMONATE BINDING TO THE PLASMALEMMA OF BLOOD AND BONE MARROW CELLS AND ITS RELATIONSHIP TO CELLULAR MATURATION</title><title>The journal of histochemistry and cytochemistry</title><addtitle>J. Histochem. Cytochem</addtitle><description>Normal human blood and bone marrow cells exposed to the pyroantimonate reaction exhibit a selective binding of pyroantimonate to sites associated with the plasmalemma of neutrophilic leukocytes, erythrocytes and certain of their precursors. Chemical distinctions exist between the plasmalemma of different types of blood and bone marrow cells, and major changes in the cationic binding ability of neutrophilic and erythrocytic cells can be correlated with different phases in their differentiation. Plasmalemmal pyroantimonate-osmium-reactive cation is bound with glycoprotein in the erythrocytic elements and to both phospholipid and glycoprotein moieties in neutrophilic cells. The cellular distribution, membrane localization and degree of membrane reactivity obtained with the pyroantimonate-osmium reaction is distinct from that obtained with Thorotrast and ruthenium red.</description><subject>Adult</subject><subject>Aldehydes</subject><subject>Antimony</subject><subject>Blood Cells</subject><subject>Bone Marrow</subject><subject>Bone Marrow Cells</subject><subject>Cell Differentiation</subject><subject>Erythrocytes</subject><subject>Glycoproteins</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Leukocytes</subject><subject>Microscopy, Electron</subject><subject>Neuraminidase</subject><subject>Neutrophils</subject><subject>Osmium</subject><subject>Periodic Acid</subject><subject>Protein Binding</subject><subject>Ruthenium</subject><subject>Semicarbazides</subject><subject>Silver</subject><subject>Staining and Labeling</subject><issn>0022-1554</issn><issn>1551-5044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1O4zAURi3EiCk_i3mAkbxCYhHGdu0mXbqpoZGcuEpdRqwsJ3GgKKUQU1U8xrzxJKWCDatPuvfo2PcD4BdG1xiH4R_S53UUoSMwwIzhgCFKj8EAIUKCbkB_glPvnxDClLLoBJxQjCM8jgbgH4fxvVbxTKRJzCUUd1wuuU5UBtUNnN_nimc6SVXGtYCTJJsm2S3UCuqZgHPJFymXIk15D0-kUlPIsymcqEzAlOe5-gtjIeViP030AuZC7uWLWTLvNf12KXne0XqZ71fn4EdtG-8uDnkGljdCx7NAqtv-i0E5DMO3YFw54qKRpZjZYYEJDUtWl2xI6qoeOedK5ypqEWW2KmlFxwwXdUFG49CigjBUDM_A5Yf3pd28bp1_M-uVL13T2Ge32XoT4VFIQ4Y78OoDLNuN962rzUu7Wtv23WBk-voN6dN09Xfs74N0W6xd9Uke-v561NsHZ5422_a5u_Fb0QF8XD087latM35tm6bTYrPb7b7A_xVXjRE</recordid><startdate>197211</startdate><enddate>197211</enddate><creator>ACKERMAN, G. ADOLPH</creator><creator>CLARK, MICHAEL A</creator><general>Histochemical Soc</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197211</creationdate><title>A CYTOCHEMICAL EVALUATION OF PYROANTIMONATE BINDING TO THE PLASMALEMMA OF BLOOD AND BONE MARROW CELLS AND ITS RELATIONSHIP TO CELLULAR MATURATION</title><author>ACKERMAN, G. ADOLPH ; CLARK, MICHAEL A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-9de2e86a415a3b1247c5fc532fdf6eeeceed4a045adc4d4951bfb2697a0b250b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Adult</topic><topic>Aldehydes</topic><topic>Antimony</topic><topic>Blood Cells</topic><topic>Bone Marrow</topic><topic>Bone Marrow Cells</topic><topic>Cell Differentiation</topic><topic>Erythrocytes</topic><topic>Glycoproteins</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Leukocytes</topic><topic>Microscopy, Electron</topic><topic>Neuraminidase</topic><topic>Neutrophils</topic><topic>Osmium</topic><topic>Periodic Acid</topic><topic>Protein Binding</topic><topic>Ruthenium</topic><topic>Semicarbazides</topic><topic>Silver</topic><topic>Staining and Labeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ACKERMAN, G. ADOLPH</creatorcontrib><creatorcontrib>CLARK, MICHAEL A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of histochemistry and cytochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ACKERMAN, G. ADOLPH</au><au>CLARK, MICHAEL A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A CYTOCHEMICAL EVALUATION OF PYROANTIMONATE BINDING TO THE PLASMALEMMA OF BLOOD AND BONE MARROW CELLS AND ITS RELATIONSHIP TO CELLULAR MATURATION</atitle><jtitle>The journal of histochemistry and cytochemistry</jtitle><addtitle>J. Histochem. Cytochem</addtitle><date>1972-11</date><risdate>1972</risdate><volume>20</volume><issue>11</issue><spage>880</spage><epage>895</epage><pages>880-895</pages><issn>0022-1554</issn><eissn>1551-5044</eissn><abstract>Normal human blood and bone marrow cells exposed to the pyroantimonate reaction exhibit a selective binding of pyroantimonate to sites associated with the plasmalemma of neutrophilic leukocytes, erythrocytes and certain of their precursors. Chemical distinctions exist between the plasmalemma of different types of blood and bone marrow cells, and major changes in the cationic binding ability of neutrophilic and erythrocytic cells can be correlated with different phases in their differentiation. Plasmalemmal pyroantimonate-osmium-reactive cation is bound with glycoprotein in the erythrocytic elements and to both phospholipid and glycoprotein moieties in neutrophilic cells. The cellular distribution, membrane localization and degree of membrane reactivity obtained with the pyroantimonate-osmium reaction is distinct from that obtained with Thorotrast and ruthenium red.</abstract><cop>London, England</cop><pub>Histochemical Soc</pub><pmid>4118198</pmid><doi>10.1177/20.11.880</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| source | Access via SAGE; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Adult Aldehydes Antimony Blood Cells Bone Marrow Bone Marrow Cells Cell Differentiation Erythrocytes Glycoproteins Histocytochemistry Humans Leukocytes Microscopy, Electron Neuraminidase Neutrophils Osmium Periodic Acid Protein Binding Ruthenium Semicarbazides Silver Staining and Labeling |
| title | A CYTOCHEMICAL EVALUATION OF PYROANTIMONATE BINDING TO THE PLASMALEMMA OF BLOOD AND BONE MARROW CELLS AND ITS RELATIONSHIP TO CELLULAR MATURATION |
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