Hemorrhagic Disease with Circulating Inhibitors of Blood Clotting: Anti-AHF and Anti-PTC in Eight Cases
In eight patients suffering from severe hemorrhagic disease it was possible to demonstrate the presence of circulating inhibitors, not heparin-like in nature. Anti-PTC was identified in two PTC deficients, anti-AHF in 5 hemophilics and both, primarily anti-AHF, in one idiopathic case. Possible etiol...
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| Veröffentlicht in: | Blood 1956-09, Vol.11 (9), p.846-855 |
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| creator | Lewis, Jessica H. Ferguson, John H. Arends, Tulio |
| description | In eight patients suffering from severe hemorrhagic disease it was possible to demonstrate the presence of circulating inhibitors, not heparin-like in nature. Anti-PTC was identified in two PTC deficients, anti-AHF in 5 hemophilics and both, primarily anti-AHF, in one idiopathic case. Possible etiologic factors inducing the appearance of such inhibitors included repeated transfusions of whole blood and plasma in all and a previous pregnancy in the idiopathic case. Two patients showed increases of gamma-globulin and presence of inhibitor in 25-33 per cent ammonium sulfate plasma fractions. Cortisone therapy was ineffective in two cases. |
| doi_str_mv | 10.1182/blood.V11.9.846.846 |
| format | Article |
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Anti-PTC was identified in two PTC deficients, anti-AHF in 5 hemophilics and both, primarily anti-AHF, in one idiopathic case. Possible etiologic factors inducing the appearance of such inhibitors included repeated transfusions of whole blood and plasma in all and a previous pregnancy in the idiopathic case. Two patients showed increases of gamma-globulin and presence of inhibitor in 25-33 per cent ammonium sulfate plasma fractions. Cortisone therapy was ineffective in two cases.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V11.9.846.846</identifier><identifier>PMID: 13355894</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Blood Coagulation ; Factor IX ; Hemophilia A - blood ; Hemorrhagic Disorders ; Humans ; Old Medline ; Thrombosis ; von Willebrand Diseases</subject><ispartof>Blood, 1956-09, Vol.11 (9), p.846-855</ispartof><rights>1956 American Society of Hematology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3176-ce99d9b9214b323dd581343c6f1e9e31853eafa169acb0d99d01e0a56391624b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13355894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lewis, Jessica H.</creatorcontrib><creatorcontrib>Ferguson, John H.</creatorcontrib><creatorcontrib>Arends, Tulio</creatorcontrib><title>Hemorrhagic Disease with Circulating Inhibitors of Blood Clotting: Anti-AHF and Anti-PTC in Eight Cases</title><title>Blood</title><addtitle>Blood</addtitle><description>In eight patients suffering from severe hemorrhagic disease it was possible to demonstrate the presence of circulating inhibitors, not heparin-like in nature. 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Cortisone therapy was ineffective in two cases.</description><subject>Blood Coagulation</subject><subject>Factor IX</subject><subject>Hemophilia A - blood</subject><subject>Hemorrhagic Disorders</subject><subject>Humans</subject><subject>Old Medline</subject><subject>Thrombosis</subject><subject>von Willebrand Diseases</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1956</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMoOj9-gSC58q4zp2m7RvBi1ukEQS_U25Amp1ukazTpFP-9qRt458UhhDzve8hDyCmwMUCZXtStc2b8CjAW4zIrhtkhI8jTMmEsZbtkxBgrkkxM4IAchvDGGGQ8zffJAXCe56XIRmQxx5XzfqkWVtMbG1AFpF-2X9LKer1uVW-7Bb3vlra2vfOBuoZeD4tp1bp-eLyk0663yXR-S1VnNpen54rajs7sYtnTKlaGY7LXqDbgyfY8Ii-3s-dqnjw83t1X04dEc5gUiUYhjKhFClnNU25MXgLPuC4aQIEcypyjahQUQumamQgzQKbyggso0pg5Iueb3nfvPtYYermyQWPbqg7dOsgSigmbAIsg34DauxA8NvLd25Xy3xKYHPzKX78y-pVCRrfDxNTZtn5dr9D8ZbZCI3C1ATB-8tOil0Fb7DQa61H30jj774If0eWLng</recordid><startdate>195609</startdate><enddate>195609</enddate><creator>Lewis, Jessica H.</creator><creator>Ferguson, John H.</creator><creator>Arends, Tulio</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195609</creationdate><title>Hemorrhagic Disease with Circulating Inhibitors of Blood Clotting: Anti-AHF and Anti-PTC in Eight Cases</title><author>Lewis, Jessica H. ; Ferguson, John H. ; Arends, Tulio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3176-ce99d9b9214b323dd581343c6f1e9e31853eafa169acb0d99d01e0a56391624b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1956</creationdate><topic>Blood Coagulation</topic><topic>Factor IX</topic><topic>Hemophilia A - blood</topic><topic>Hemorrhagic Disorders</topic><topic>Humans</topic><topic>Old Medline</topic><topic>Thrombosis</topic><topic>von Willebrand Diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lewis, Jessica H.</creatorcontrib><creatorcontrib>Ferguson, John H.</creatorcontrib><creatorcontrib>Arends, Tulio</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lewis, Jessica H.</au><au>Ferguson, John H.</au><au>Arends, Tulio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemorrhagic Disease with Circulating Inhibitors of Blood Clotting: Anti-AHF and Anti-PTC in Eight Cases</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1956-09</date><risdate>1956</risdate><volume>11</volume><issue>9</issue><spage>846</spage><epage>855</epage><pages>846-855</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>In eight patients suffering from severe hemorrhagic disease it was possible to demonstrate the presence of circulating inhibitors, not heparin-like in nature. 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| fulltext | fulltext |
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| ispartof | Blood, 1956-09, Vol.11 (9), p.846-855 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_81670710 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Blood Coagulation Factor IX Hemophilia A - blood Hemorrhagic Disorders Humans Old Medline Thrombosis von Willebrand Diseases |
| title | Hemorrhagic Disease with Circulating Inhibitors of Blood Clotting: Anti-AHF and Anti-PTC in Eight Cases |
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