Demonstration of Double-Stranded Ribonucleic Acid in Concentrates of RNA Viruses

Summary Nucleic acid preparations from unpurified concentrates of Newcastle disease virus, Sindbis virus and Semliki Forest virus were found to contain up to 2% double-stranded RNA. Double-stranded RNA was identified by reaction with antisera specific for double-stranded RNA, capacity to protect pri...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1972-11, Vol.141 (2), p.440-444
Hauptverfasser:	Field, A. Kirk, Lampson, George P., Tytell, Alfred A., Hilleman, Maurice R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - analysis Cells, Cultured Chick Embryo Complement Fixation Tests Immune Sera Interferon Inducers - analysis Kidney Newcastle disease virus - analysis Nucleic Acid Denaturation Poly I-C Rabbits - immunology Ribonucleases RNA, Viral - isolation & purification Semliki forest virus - analysis Sindbis Virus - analysis
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